Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis

Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe mice

(2022) Santosh Karnewar et al.   ATHEROSCLEROSIS

Non-alcoholic fatty liver disease

(2021) Elizabeth E Powell et al.   LANCET

Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease

(2020) Ze Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

NAFLD and increased risk of cardiovascular disease: clinical associations, pathophysiological mechanisms and pharmacological implications

(2020) Giovanni Targher et al.   GUT

NAFLD and cardiovascular diseases: a clinical review

(2020) Philipp Kasper et al.   Clinical Research in Cardiology

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

(2019) Eric S. Muise et al.   PLoS One

From NASH to HCC: current concepts and future challenges

(2019) Quentin M. Anstee et al.   Nature Reviews Gastroenterology & Hepatology

The Global Epidemiology of NAFLD and NASH in Patients with type 2 diabetes: A Systematic Review and Meta-analysis

(2019) Zobair M. Younossi et al.   JOURNAL OF HEPATOLOGY

Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis

(2019) Geneviève Marcelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolution of NAFLD and Its Management

(2019) Manpreet S. Mundi et al.   NUTRITION IN CLINICAL PRACTICE

LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway

(2019) Xue-Yang Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

AMPK-Mediated Regulation of Lipid Metabolism by Phosphorylation

(2018) Qi Wang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway

(2018) Yufan Zang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice

(2018) Chian-Jiun Liou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Fat Mass and Obesity Associated (FTO) Gene and Hepatic Glucose and Lipid Metabolism

(2018) Tooru Mizuno   Nutrients

Lipid accumulation product is a powerful tool to predict non-alcoholic fatty liver disease in Chinese adults

(2017) Haijiang Dai et al.   Nutrition & Metabolism

The Metabolic Phenotype in Obesity: Fat Mass, Body Fat Distribution, and Adipose Tissue Function

(2017) Gijs H. Goossens   Obesity Facts

Immunology in the liver — from homeostasis to disease

(2016) Felix Heymann et al.   Nature Reviews Gastroenterology & Hepatology

PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse LiverSignificance

(2015) Annie Demers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The roles of c-Jun NH2-terminal kinases (JNKs) in obesity and insulin resistance

(2015) Martin Pal et al.   JOURNAL OF PHYSIOLOGY-LONDON

Esculetin, a coumarin derivative, suppresses adipogenesis through modulation of the AMPK pathway in 3T3-L1 adipocytes

(2015) Younghwa Kim et al.   Journal of Functional Foods

Non-alcoholic fatty liver disease, obesity and the metabolic syndrome

(2014) Peter Dietrich et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis

(2013) Robin D. Clugston et al.   JOURNAL OF LIPID RESEARCH

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

(2013) Annika Mehlem et al.   Nature Protocols

Effect of adipose tissue insulin resistance on metabolic parameters and liver histology in obese patients with nonalcoholic fatty liver disease

(2011) Romina Lomonaco et al.   HEPATOLOGY

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

(2009) Aparna Purushotham et al.   Cell Metabolism

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

Renal and Vascular Mechanisms of Thiazolidinedione-Induced Fluid Retention

(2008) Tianxin Yang et al.   PPAR Research