Icariin decreases cell proliferation and inflammation of rheumatoid arthritis-fibroblast like synoviocytes via GAREM1/MAPK signaling pathway

New Druggable Targets for Rheumatoid Arthritis Based on Insights From Synovial Biology

(2022) Gurvisha Sandhu et al.   Frontiers in Immunology

Assessment of IL‐1β, IL‐6, TNF‐α, IL‐8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis

(2022) Wael Alturaiki et al.   International Journal of Rheumatic Diseases

GAREM1 is involved in controlling body mass in mice and humans

(2022) Tasuku Nishino et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ononin induces cell apoptosis and reduces inflammation in rheumatoid arthritis fibroblast-like synoviocytes by alleviating MAPK and NF-κB signaling pathways

(2021) Yue Meng et al.   ACTA BIOCHIMICA POLONICA

MAPK /ERK signaling pathway: A potential target for the treatment of intervertebral disc degeneration

(2021) Hai-Jun Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Icariin arrests cell cycle progression and induces cell apoptosis through the mitochondrial pathway in human fibroblast-like synoviocytes

(2021) Luya Pu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rosmanol and Carnosol Synergistically Alleviate Rheumatoid Arthritis through Inhibiting TLR4/NF-κB/MAPK Pathway

(2021) Lianchun Li et al.   MOLECULES

Management of Rheumatoid Arthritis: An Overview

(2021) Andrei-Flavius Radu et al.   Cells

Icariin‐induced inhibition of SIRT6/NF‐κB triggers redox mediated apoptosis and enhances anti‐tumor immunity in triple‐negative breast cancer

(2020) Linjiang Song et al.   CANCER SCIENCE

Immunomodulatory effects of berberine on the inflamed joint reveal new therapeutic targets for rheumatoid arthritis management

(2020) Peng Shen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Anti-angiogenic effect of Shikonin in rheumatoid arthritis by downregulating PI3K/AKT and MAPKs signaling pathways

(2020) Chunfang Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Icariin enhances cell survival in lipopolysaccharide‑induced synoviocytes by suppressing ferroptosis via the Xc‑/GPX4 axis

(2020) Huasong Luo et al.   Experimental and Therapeutic Medicine

Icariin alleviates murine lupus nephritis via inhibiting NF-κB activation pathway and NLRP3 inflammasome

(2018) Bofeng Su et al.   LIFE SCIENCES

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

(2018) Bryant R England et al.   BMJ-British Medical Journal

Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications

(2018) Bryant R England et al.   BMJ-British Medical Journal

MicroRNA-128 contributes to the progression of gastric carcinoma through GAREM-mediated MAPK signaling activation

(2018) Lu Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Resveratrol Alleviates Rheumatoid Arthritis via Reducing ROS and Inflammation, Inhibiting MAPK Signaling Pathways, and Suppressing Angiogenesis

(2018) Guliang Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Icariin Prevents IL-1β-Induced Apoptosis in Human Nucleus Pulposus via the PI3K/AKT Pathway

(2017) Xiangyu Deng et al.   Evidence-based Complementary and Alternative Medicine

GAREM1 regulates the PR interval on electrocardiograms

(2017) Hye Ok Kim et al.   JOURNAL OF HUMAN GENETICS

Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis

(2016) Somaiya Mateen et al.   CLINICA CHIMICA ACTA

Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis

(2015) Yu Sun et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

(2015) Chenrui Li et al.   LIFE SCIENCES

A Natural Flavonoid Glucoside, Icariin, Regulates Th17 and Alleviates Rheumatoid Arthritis in a Murine Model

(2014) Liqun Chi et al.   MEDIATORS OF INFLAMMATION

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

GAREM, a Novel Adaptor Protein for Growth Factor Receptor-bound Protein 2, Contributes to Cellular Transformation through the Activation of Extracellular Signal-regulated Kinase Signaling

(2009) Kyoko Tashiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY