Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 912, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2021.174585
Keywords
Icariin; Fibroblast-like synoviocytes; Cell cycle; Apoptosis; Mitochondrial pathway
Categories
Funding
- National Natural ScienceFoundation of China [31972921]
- Fundamental Research Funds for the Central Universities, JLU
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Icariin can inhibit the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, indicating its potential for the treatment of RA.
Rheumatoid arthritis (RA) is a highly disabling autoimmune disorder, characterized by the proliferation of Fibroblast-like Synoviocytes (FLSs). Icariin is a prenylated flavonol glycoside extracted from the medical plant Epimedium, which can inhibit the proliferation and migration of FLSs. However, the potential mechanism of icariin to alleviate RA remains unclear. In this study, icariin inhibited the migration and proliferation of FLSs in a concentration-dependent manner, by inducing G2/M phase arrest and apoptosis. Icariin reduced the mitochondrial transmembrane potential, upregulated cytosolic cytochrome c and increased the level of intracellular reactive oxygen species (ROS). In conclusion, icariin inhibited the proliferation of FLSs by interfering with the cell cycle process and inducing cell apoptosis, suggesting its potential use for the treatment of RA.
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