Withaferin A suppressed hepatocellular carcinoma progression through inducing IGF2BP3/FOXO1/JAK2/STAT3 pathway-mediated ROS production

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

(2022) Amandeep Singh et al.   MOLECULES

Osteopontin promotes hepatocellular carcinoma progression through inducing JAK2/STAT3/NOX1-mediated ROS production

(2022) Qipeng Wu et al.   Cell Death & Disease

IGF2BP3 worsens lung cancer through modifying long non-coding RNA CERS6-AS1/microRNA-1202 axis

(2022) An Yan et al.   CURRENT MEDICINAL CHEMISTRY

Molecular dynamics simulations reveal the inhibitory mechanism of Withanolide A against α-glucosidase and α-amylase

(2022) Habeebat Adekilekun Oyewusi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Hepatocellular Carcinoma in Africa: Challenges and Opportunities

(2022) Mohamed El-Kassas et al.   Frontiers in Medicine

Prognostic and predictive role of a metabolic rate‐limiting enzyme signature in hepatocellular carcinoma

(2021) Zhangding Wang et al.   CELL PROLIFERATION

Advances in RNA Epigenetic Modifications in Hepatocellular Carcinoma and Potential Targeted Intervention Strategies

(2021) Li-Ran Zhu et al.   Frontiers in Cell and Developmental Biology

Predicting Hepatocellular Carcinoma With Minimal Features From Electronic Health Records: Development of a Deep Learning Model

(2021) Chia-Wei Liang et al.   JMIR Cancer

Anti-cancer effect of gallic acid in presence of low level laser irradiation: ROS production and induction of apoptosis and ferroptosis

(2020) Khatereh Khorsandi et al.   Cancer Cell International

miR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway

(2020) Huadong Yin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer

(2020) Zhou Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner

(2020) Jingya Gu et al.   Oxidative Medicine and Cellular Longevity

SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production

(2019) Changwei Dou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Increased IGF2BP3 expression promotes the aggressive phenotypes of colorectal cancer cells in vitro and vivo

(2019) Weimin Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

EZH2 promotes invasion and tumour glycolysis by regulating STAT3 and FoxO1 signalling in human OSCC cells

(2019) Min Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The combination of the glycolysis inhibitor 2-DG and sorafenib can be effective against sorafenib-tolerant persister cancer cells

(2019) Li Wang et al.   OncoTargets and Therapy

Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells

(2018) Shuxian Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plants as sources of natural and recombinant anti-cancer agents

(2018) J.F. Buyel   BIOTECHNOLOGY ADVANCES

Glycosides from Medicinal Plants as Potential Anticancer Agents: Emerging Trends towards Future Drugs

(2018) Haroon Khan et al.   CURRENT MEDICINAL CHEMISTRY

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Withanolides isolated from Nicandra physaloides protect liver cells against oxidative stress-induced damage

(2018) Liqing Wang et al.   Journal of Functional Foods

HCCDB: A Database of Hepatocellular Carcinoma Expression Atlas

(2018) Qiuyu Lian et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Natural product pectolinarigenin inhibits proliferation, induces apoptosis, and causes G2/M phase arrest of HCC via PI3K/AKT/mTOR/ERK signaling pathway

(2018) Tianchun Wu et al.   OncoTargets and Therapy

Role of STAT3 and FOXO1 in the Divergent Therapeutic Responses of Non-metastatic and Metastatic Bladder Cancer Cells to miR-145

(2017) Guosong Jiang et al.   MOLECULAR CANCER THERAPEUTICS

Withaferin A induces Nrf2-dependent protection against liver injury: Role of Keap1-independent mechanisms

(2016) Dushani L. Palliyaguru et al.   FREE RADICAL BIOLOGY AND MEDICINE

Withaferin A Induces ROS-Mediated Paraptosis in Human Breast Cancer Cell-Lines MCF-7 and MDA-MB-231

(2016) Kamalini Ghosh et al.   PLoS One

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

The centella asiatica juice effects on DNA damage, apoptosis and gene expression in hepatocellular carcinoma (HCC)

(2014) Faridah Hussin et al.   BMC Complementary and Alternative Medicine

Down Regulation of FOXO1 Promotes Cell Proliferation in Cervical Cancer

(2014) Shyam Babu Prasad et al.   Journal of Cancer

Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90

(2012) Hui-Chun Wang et al.   PLoS One

Growth Inhibition and Apoptosis Induced by Osthole, A Natural Coumarin, in Hepatocellular Carcinoma

(2012) Lurong Zhang et al.   PLoS One

Withaferin A Synergizes the Therapeutic Effect of Doxorubicin through ROS-Mediated Autophagy in Ovarian Cancer

(2012) Miranda Y. Fong et al.   PLoS One

FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

(2011) H. Zhang et al.   CANCER RESEARCH