Journal
MOLECULES
Volume 27, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/molecules27030886
Keywords
withanolides; withaferin A; anticancer; anti-inflammatory; anti-bacterial; anti-leishmaniasis
Funding
- NIH/NCI [NIH/NCI-1R01CA185972]
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This article reviews the medicinal implications, particularly the anticancer properties, of natural withanolides and their synthetic analogs. The analysis of relevant literature demonstrates the translational potential of these promising compounds.
Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. In this review, we discuss the literature evidence related to the medicinal implications, particularly anticancer properties of natural withanolides and their synthetic analogs, and provide perspectives on the translational potential of these promising compounds.
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