Article
Pharmacology & Pharmacy
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang
Summary: Liver cancer is a common malignancy with drug resistance being a major challenge in treatment. This study demonstrates that Dihydrotanshinone (DHTS) can inhibit the growth of hepatocellular carcinoma by suppressing the JAK2/STAT3 signaling pathway, suggesting its potential as a chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liheng Li, Chengjiang Xiao, Ke He, Guoan Xiang
Summary: The study revealed that circ_0072088 is highly expressed in HCC, promoting proliferation, migration, and invasion of liver cancer cells while inhibiting apoptosis. It activates the JAK2/STAT3 signaling pathway by serving as a molecular sponge of miR-375.
Article
Biochemistry & Molecular Biology
Baojun Han, Zhiming An, Teng Gong, Yu Pu, Ke Liu
Summary: This study aimed to investigate the molecular mechanism of LCN2 regulating abnormal proliferation of HCC cells. The expression levels of LCN2 in hepatocellular carcinoma tissues were examined, and the effects of LCN2 on cell proliferation and aerobic glycolysis were analyzed. The results showed that LCN2 was upregulated in hepatocellular carcinoma tissues and significantly promoted cell proliferation and aerobic glycolysis, potentially through activating the JAK2/STAT3 signaling pathway.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Oncology
Yabing Hu, Yongchu Huang, Xiaohang Xie, Longshan Li, Yong Zhang, Xiaochao Zhang
Summary: In this study, we found that high expression of ARF6 is associated with poor prognosis and promotes the proliferation of hepatocellular carcinoma (HCC). ARF6 was upregulated in HCC tissues and correlated with poor tumor differentiation, incomplete tumor encapsulation, advanced tumor TNM stage, and poor prognosis. ARF6 activated the STAT3 signaling pathway to enhance HCC cell proliferation and tumor growth. These findings suggest that ARF6 may serve as a potential prognostic and therapeutic target for HCC patients.
CANCER CELL INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
Hyun-Soo Park, Joo-Hui Han, Jeong Won Park, Do-Hyung Lee, Keun-Woo Jang, Miji Lee, Kyung-Sun Heo, Chang-Seon Myung
Summary: The study found that sodium propionate (SP) inhibits proliferation and induces apoptosis in breast cancer cells by inhibiting JAK2/STAT3 signaling, increasing ROS levels, and activating p38 MAPK.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Fisheries
Lu Li, Wan Li, Yufeng Liu, Xin Jin, Yanbo Yu, Hongjin Lin
Summary: This study investigated the effects of TBBPA and Pb on grass carp hepatocytes and their underlying toxicological mechanisms. The results showed that combined exposure to TBBPA and Pb resulted in more severe cellular damage compared to single exposures, leading to apoptosis of the cells through the activation of JAK2/STAT3 signaling pathway by induction of oxidative stress. Treatment with N-acetyl-L-cysteine (NAC) effectively alleviated the oxidative damage and loss of membrane potential. This study provides new insights into the toxicological mechanisms of TBBPA and Pb, as well as a potential treatment for their toxicity.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Oncology
Yunzhi Liu, Qishan Xu, Fan Deng, Zhuojun Zheng, Jialiang Luo, Ping Wang, Jia Zhou, Xiao Lu, Liyun Zhang, Zhengliang Chen, Qifan Zhang, Qingyun Chen, Daming Zuo
Summary: This study found that increased expression of HERC2 is associated with poor prognosis in HCC patients. HERC2 enhances the stemness and PD-L1-mediated immune evasion of HCC cells, which is likely linked to the activation of the JAK2/STAT3 pathway during inflammation-induced tumorigenesis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Food Science & Technology
Qi Wang, Xia Wu, Jian Zhang, Miao Song, Jiayu Du, Yilong Cui, Yanfei Li
Summary: Di-n-butyl phthalate (DBP) is known to negatively affect male reproduction, particularly by inhibiting testosterone synthesis. However, the specific mechanism behind this inhibition and effective intervention measures are limited. This study found that DBP activates the ROS/JAK2/STAT3 signaling pathway, promotes mitophagy and apoptosis, leading to a decrease in testosterone synthesis. Furthermore, it was discovered that lycopene supplementation reverses these effects, inhibiting the ROS/JAK2/STAT3 signaling pathway, reducing mitophagy and apoptosis, and improving testosterone synthesis. This research enhances our understanding of the mechanism behind DBP-induced testosterone synthesis inhibition and identifies lycopene as an effective strategy for prevention and treatment of DBP poisoning.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Lili Zhu, Xiaobei Yang, Jingyu Feng, Jian Mao, Qidong Zhang, Mengru He, Yang Mi, Yingwu Mei, Ge Jin, Haifeng Zhang
Summary: The study reveals that CYP2E1 plays a role in hepatocarcinogenesis by manipulating the Wnt/Dvl2/beta-catenin pathway through inducing ROS accumulation, which leads to the inhibition of tumor growth and metastasis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Yuan-Deng Luo, Xiao-Yu Liu, Lei Fang, Hong-Qiang Yu, Yu-Jun Zhang, Min Chen, Lei-Da Zhang, Chuan-Ming Xie
Summary: This study elucidated the mechanism of hepatocytic Kras/Erk-driven mTOR activation and its downstream targets, identified PEG3 as a new prognostic biomarker for HCC with Kras/Erk and mTOR hyperactivation, and provided a potential therapeutic strategy for this subset of HCC patients.
Review
Geriatrics & Gerontology
Xin-Yi Dai, Lin Liu, Fan-He Song, Shao-Jie Gao, Jia-Yi Wu, Dan-Yang Li, Long-Qing Zhang, Dai-Qiang Liu, Ya-Qun Zhou, Wei Mei
Summary: Chronic pain is a significant health concern due to its common occurrence, long-lasting nature, and associated mental stress. The JAK2/STAT3 signaling pathway has been found to play a crucial role in different stages of chronic pain, and inhibitors targeting this pathway show therapeutic potential. Activation of JAK2/STAT3 triggers chronic pain by interacting with microglia and astrocytes, releasing proinflammatory cytokines, inhibiting anti-inflammatory cytokines, and affecting synaptic plasticity. Retrospective analysis of pharmacological inhibitors for JAK2/STAT3 reveals their promising effect in treating different types of chronic pain.
Article
Cell Biology
Mengqi Zhuang, Xiaotong Ding, Wenli Song, Huimin Chen, Hui Guan, Yang Yu, Zicheng Zhang, Xinzhe Dong
Summary: IL-6 is elevated in the serum of NPC patients, and higher expressions of IL-6, STAT3, p-STAT3, JAK2, p-JAK2, and CyclinD1 in tissues are correlated with TNM staging and lymph node metastasis in NPC. Positive expressions of IL-6 and p-STAT3 are risk factors for poor prognosis in NPC patients.
Article
Pharmacology & Pharmacy
Yasmeen M. Attia, Rasha A. Tawfiq, Abdullah A. Gibriel, Aya A. Ali, Dina H. Kassem, Olfat A. Hammam, Mohamed M. Elmazar
Summary: The study found that obeticholic acid (OCA) as an FXR agonist has a significant inhibitory effect in NASH-related HCC animal model, slowing down the development and progression of the disease by interfering with the SOCS3/Jak2/STAT3 pathway.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Oncology
Xin Zhang, Hongwei Zhang, Zhibin Liao, Jiacheng Zhang, Huifang Liang, Weixing Wang, Jia Yu, Keshuai Dong
Summary: This study reveals that SHC4 activates STAT3 signaling to promote hepatocellular carcinoma (HCC) progression. SHC4 overexpression in HCC is associated with poor prognosis, increased migration and invasion. SHC4 enhances cell proliferation, colony formation, migration, and invasion, as well as cell cycle progression and epithelial-mesenchymal transition (EMT) in HCC cells. Additionally, the activation of STAT3 signaling is observed in SHC4 overexpressed HCC cells and tissues. Moreover, intervention of STAT3 confirms its importance in the oncogenic role of SHC4 in HCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Environmental Sciences
Tingting Xia, Yijie Gu, Jiaqing Shen, Lu Zheng, Chunfang Xu
Summary: Research has shown that limonin has protective effects on acute pancreatitis by reducing the levels of inflammation initiators and modulating the JAK2/STAT3 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)