Selective targeting of lectins and their macropinocytosis in urothelial tumours: translation from in vitro to ex vivo

Targeting glycans for CAR therapy: The advent of sweet CARs

(2022) Zoe Raglow et al.   MOLECULAR THERAPY

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets

(2021) Shaojuan Song et al.   Frontiers in Oncology

Cytotoxic Activity of LLO Y406A Is Targeted to the Plasma Membrane of Cancer Urothelial Cells

(2021) Nataša Resnik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Unconventional endocytic mechanisms

(2021) Henri-François Renard et al.   CURRENT OPINION IN CELL BIOLOGY

The role of endolysosomal trafficking in anticancer drug resistance

(2021) Noor A. Hussein et al.   DRUG RESISTANCE UPDATES

Attachment of Cancer Urothelial Cells to the Bladder Epithelium Occurs on Uroplakin-Negative Cells and Is Mediated by Desmosomal and Not by Classical Cadherins

(2021) Urška Dragin Jerman et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Macropinocytosis: Insights from immunology and cancer

(2020) Jennifer L. Stow et al.   CURRENT OPINION IN CELL BIOLOGY

Current status of the development of intravesical drug delivery systems for the treatment of bladder cancer

(2020) Young Wook Choi et al.   Expert Opinion on Drug Delivery

Vitamin A Rich Diet Diminishes Early Urothelial Carcinogenesis by Altering Retinoic Acid Signaling

(2020) Daša Zupančič et al.   Cancers

The biology and rationale of targeting nectin-4 in urothelial carcinoma

(2020) Elisabeth I. Heath et al.   Nature Reviews Urology

Tumor heterogeneity in muscle-invasive bladder cancer

(2020) Ho Won Kang et al.   Translational Andrology and Urology

Utility and Validation of the AUA/SUO Risk Grouping for Nonmuscle Invasive Bladder Cancer in a Contemporary Cohort

(2019) Chad R. Ritch et al.   JOURNAL OF UROLOGY

A Novel Method to Image Macropinocytosis in Vivo

(2018) Lunhao Chen et al.   Frontiers in Neuroscience

Increased endocytosis of magnetic nanoparticles into cancerous urothelial cells versus normal urothelial cells

(2017) Jasna Lojk et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Differentiation-dependent rearrangements of actin filaments and microtubules hinder apical endocytosis in urothelial cells

(2017) Larisa Tratnjek et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Chitosan hydrochloride has no detrimental effect on bladder urothelial cancer cells

(2017) Tanja Višnjar et al.   TOXICOLOGY IN VITRO

Over forty years of bladder cancer glycobiology: Where do glycans stand facing precision oncology?

(2017) Rita Azevedo et al.   Oncotarget

Uroplakin traffic through the Golgi apparatus induces its fragmentation: new insights from novel in vitro models

(2017) Tanja Višnjar et al.   Scientific Reports

Differentiation-related glycan epitopes identify discrete domains of the muscle glycocalyx

(2016) Brian J McMorran et al.   GLYCOBIOLOGY

Glycolipids and Lectins in Endocytic Uptake Processes

(2016) Ludger Johannes et al.   JOURNAL OF MOLECULAR BIOLOGY

Bladder cancer

(2016) Ashish M Kamat et al.   LANCET

The effect of the size of fluorescent dextran on its endocytic pathway

(2015) Lei Li et al.   CELL BIOLOGY INTERNATIONAL

Characteristic Changes in Cell Surface Glycosylation Accompany Intestinal Epithelial Cell (IEC) Differentiation: High Mannose Structures Dominate the Cell Surface Glycome of Undifferentiated Enterocytes

(2015) Dayoung Park et al.   MOLECULAR & CELLULAR PROTEOMICS

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

(2015) Ikuhiko Nakase et al.   Scientific Reports

Glycosylation of uroplakins. Implications for bladder physiopathology

(2014) Iwona Kątnik-Prastowska et al.   GLYCOCONJUGATE JOURNAL

Expression of the Clustered NeuAcα2–3GalβO-Glycan Determines the Cell Differentiation State of the Cells

(2014) Kiyoshi Higashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endophilin marks and controls a clathrin-independent endocytic pathway

(2014) Emmanuel Boucrot et al.   NATURE

Cellular origin of bladder neoplasia and tissue dynamics of its progression to invasive carcinoma

(2014) Kunyoo Shin et al.   NATURE CELL BIOLOGY

Air–liquid and liquid–liquid interfaces influence the formation of the urothelial permeability barrier in vitro

(2013) Tanja Višnjar et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Synergistic targeting/prodrug strategies for intravesical drug delivery — Lectin-modified PLGA microparticles enhance cytotoxicity of stearoyl gemcitabine by contact-dependent transfer

(2013) L. Neutsch et al.   JOURNAL OF CONTROLLED RELEASE

Overexpression of tumour-ssociated carbohydrate antigen sialyl-Tn in advanced bladder tumours

(2013) José Alexandre Ferreira et al.   Molecular Oncology

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Biomimetic Delivery Strategies at the Urothelium: Targeted Cytoinvasion in Bladder Cancer Cells via Lectin Bioconjugates

(2013) Lukas Neutsch et al.   PHARMACEUTICAL RESEARCH

Selective binding of lectins to normal and neoplastic urothelium in rat and mouse bladder carcinogenesis models

(2013) Daša Zupančič et al.   PROTOPLASMA

Heterogeneity of uroplakin localization in human normal urothelium, papilloma and papillary carcinoma

(2013) Dasa Zupancic et al.   Radiology and Oncology

Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis

(2013) Adam McCluskey et al.   TRAFFIC

Lectin bioconjugates trigger urothelial cytoinvasion – A glycotargeted approach for improved intravesical drug delivery

(2012) L. Neutsch et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Glycan profiling of endometrial cancers using lectin microarray

(2012) Yoshihiro Nishijima et al.   GENES TO CELLS

Freeze-Fracture Replica Immunolabelling Reveals Urothelial Plaques in Cultured Urothelial Cells

(2012) Mateja Erdani Kreft et al.   PLoS One

Uptake of ricinB-quantum dot nanoparticles by a macropinocytosis-like mechanism

(2012) Tore Iversen et al.   JOURNAL OF NANOBIOTECHNOLOGY

Hyperplasia as a mechanism for rapid resealing urothelial injuries and maintaining high transepithelial resistance

(2011) Tanja Višnjar et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Expression and localization of four uroplakins in urothelial preneoplastic lesions

(2011) Daša Zupančič et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Urothelial Plaque Formation in Post-Golgi Compartments

(2011) Samo Hudoklin et al.   PLoS One

Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats

(2011) Daša Zupančič et al.   VIRCHOWS ARCHIV

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling

(2010) Mirkka Koivusalo et al.   JOURNAL OF CELL BIOLOGY

Apical Plasma Membrane Traffic in Superficial Cells of Bladder Urothelium

(2009) Mateja Erdani Kreft et al.   Annals of the New York Academy of Sciences

Endocytotic activity of bladder superficial urothelial cells is inversely related to their differentiation stage

(2009) Mateja Erdani Kreft et al.   DIFFERENTIATION

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

Targeted drug delivery: Binding and uptake of plant lectins using human 5637 bladder cancer cells

(2008) Verena E. Plattner et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Glycosylation in bladder cancer

(2008) Chikara Ohyama   International Journal of Clinical Oncology