Article
Biochemistry & Molecular Biology
Ryota Shimamura, Yohei Ohashi, Yukimi Yamamoto Taniguchi, Mariko Kato, Tomohiko Tsuge, Takashi Aoyama
Summary: Arabidopsis PLD zeta 1 and PLD zeta 2 localize to specific compartments within plant cells, impacting membrane trafficking processes. Their distinctive subcellular locations and functions suggest overlapping yet unique roles in membrane transport pathways.
PLANT MOLECULAR BIOLOGY
(2022)
Review
Cell Biology
Peter W. Halcrow, Jonathan D. Geiger, Xuesong Chen
Summary: Chemoresistance is a major obstacle for cancer patients and effective strategies to overcome it are lacking. Chloroquine and hydroxychloroquine are utilized for treating various cancers by inhibiting autophagy, in addition to enhancing the anti-cancer effects of chemotherapeutic drugs. Their multi-faceted mechanisms include altering pH levels in cellular compartments to disrupt tumorigenesis and combating chemoresistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sofia A. Quinodoz, Joanna W. Jachowicz, Prashant Bhat, Noah Ollikainen, Abhik K. Banerjee, Isabel N. Goronzy, Mario R. Blanco, Peter Chovanec, Amy Chow, Yolanda Markaki, Jasmine Thai, Kathrin Plath, Mitchell Guttman
Summary: Research shows that RNA and DNA play crucial roles in the spatial organization within the nucleus. Through the use of RD-SPRITE technology, the connections between RNA and chromatin structures have been revealed, providing a comprehensive analysis of nuclear functions.
Article
Biology
Anitha P. Govind, Okunola Jeyifous, Theron A. Russell, Zola Yi, Aubrey Weigel, Abhijit Ramaprasad, Luke Newell, William Ramos, Fernando M. Valbuena, Jason C. Casler, Jing-Zhi Yan, Benjamin S. Glick, Geoffrey T. Swanson, Jennifer Lippincott-Schwartz, William N. Green
Summary: Increased neuronal activity leads to changes in N-glycan structures on dendritic surface glycoproteins, which are mediated by the growth and proliferation of Golgi satellites. These Golgi satellites act as distal glycosylation stations, impacting the dendritic surface and potentially influencing synaptic plasticity and diseases.
Review
Endocrinology & Metabolism
Leonie Rieger, Rosemary O'Connor
Summary: The internalization and localization of the IGF-1 receptor play crucial roles in cell signaling and biological processes, with different cell types and cell adhesion receptors regulating this process. Further study on how IGF-1R intracellular trafficking and compartmentalized signaling is controlled, particularly in cancer, is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Plant Sciences
Liang Zhang, Jingwen Ma, Huan Liu, Qian Yi, Yanan Wang, Jingjing Xing, Peipei Zhang, Shengdong Ji, Mingjun Li, Jingyuan Li, Jinbo Shen, Jinxing Lin
Summary: The R-SNAREs VAMP721 and VAMP722 in Arabidopsis are found to play crucial roles in intracellular trafficking, affecting auxin distribution and plant growth by regulating the polar localization of auxin transporters.
Article
Computer Science, Interdisciplinary Applications
Manca Zerovnik Mekuc, Ciril Bohak, Eva Bones, Samo Hudoklin, Rok Romih, Matija Marolt
Summary: This article presents a method for automatic segmentation, reconstruction, and analysis of intracellular compartments' ultrastructure using volumetric data obtained by electron microscopy. The proposed method achieves high accuracy in segmentation, reconstruction, and morphological analysis, providing important technical support for the study of intracellular compartments.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Multidisciplinary Sciences
Silvia Holler, Stuart Bartlett, Richard J. G. Loeffler, Federica Casiraghi, Claro Ignacio Sainz Diaz, Julyan H. E. Cartwright, Martin M. Hanczyc
Summary: This paper investigates the features of alkaline hydrothermal vents and their significance in the origins of life. By integrating fatty alcohol decanol into inorganic minerals, novel three-dimensional structures were produced, and it has been demonstrated that the interaction between fatty alcohols and inorganic mineral structures may have played a crucial role in the formation of protocells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Yoko Ito, Nicolas Esnay, Louise Fougere, Matthieu Pierre Platre, Fabrice Cordelieres, Yvon Jaillais, Yohann Boutte
Summary: A key characteristic of sphingolipids is the presence of very long chain fatty acids (VLCFAs), which play a role in intracellular traffic to vacuoles. Additionally, the anionic phospholipid PI3P is involved in protein sorting at late endosomes in plant cells. The distribution of PI3P between TGN and MVBs is influenced by VLCFAs, and there may be transfer of PI3P from TGNs to MVBs with the involvement of VLCFAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Camilla Godlee, Ondrej E. Cerny, Mei Liu, Samkeliso W. Blundell, Alanna M. Gallagher, Meriam M. Shahin, David M. Holden
Summary: This study explores the targeting, membrane integration, and trafficking mechanisms of the Salmonella effector SteD. SteD integrates into the early secretory pathway membranes through two steps and hijacks a vesicular trafficking pathway to reach MHCII compartments. This research highlights the intricate interaction between bacterial pathogens and host cell biology at the molecular level.
Article
Biochemistry & Molecular Biology
Alexander A. Mironov, Maksim A. Savin, Anna V. Zaitseva, Ivan D. Dimov, Irina S. Sesorova
Summary: The blood group system is based on the A or B antigens located on the surface of blood cells and is synthesized using unique Golgi glycosylation enzymes. Antibodies are produced against antigens of different blood groups. There are several hypotheses explaining the formation of these antibodies, including natural antibodies, gut bacteria-derived antibodies, and antibodies formed due to glycosylation mistakes or de-sialylation. Further research is needed to determine which hypothesis is correct.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kelly A. McCorkell, Nipun Jayachandran, Michelle D. Cully, Jacquelyn Freund-Brown, Tiffany Weinkopff, James Monslow, Yinling Hu, Ellen Pure, Bruce D. Freedman, Jorge Alvarez, Michael P. Cancro, Michael J. May
Summary: Global inactivation of IKK-alpha leads to defective lymph node formation and B cell maturation. IKK-alpha in distinct EC-derived compartments is uniquely required to promote B cell homeostasis and LN development, and LEC-intrinsic IKK-alpha is absolutely essential for LN formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Cell Biology
Karsten Rippe, Argyris Papantonis
Summary: Recent studies suggest that phase separation contributes to the formation of 'transcriptional condensates', but the role of intrinsically disordered regions in transcription-relevant factors is crucial in both 'transcriptional condensates' and 'transcription factories'.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuejun Cheng, Jie Huang, Ruoxu Wang, Yue Xu, Nan Wu, Jie Zhou, Xueyang Liu, Hong Wang, Hongyu Chen
Summary: We demonstrate the spontaneous formation of enclosed compartments with microporous shells and enriched biopolymers through the coprecipitation of silica and biopolymers. This synthetic method allows for mild reaction conditions and random mixing of reagents. The inclusion of divalent cation Ca2+ is crucial for co-precipitation and the subsequent formation of hollow compartments. The discovery of these enclosed compartments containing biopolymers opens new avenues for theorizing the host of early life forms.
Article
Multidisciplinary Sciences
Moritz Bauer, Enrique Vidal, Eduard Zorita, Nil Uresin, Stefan F. Pinter, Guillaume J. Filion, Bernhard Payer
Summary: The study reveals the presence of A/B-like compartments on the inactive X chromosome, guiding TAD formation independently of transcription during X-reactivation. The formation of TADs and transcriptional reactivation are shown to be causally independent during X-reactivation, with Xist identified as a common factor.
NATURE COMMUNICATIONS
(2021)