Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon

R-spondin family biology and emerging linkages to cancer

(2023) Zhimin He et al.   ANNALS OF MEDICINE

LGR4, a G Protein-Coupled Receptor With a Systemic Role: From Development to Metabolic Regulation

(2022) Joanna Filipowska et al.   Frontiers in Endocrinology

A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation

(2021) Zizhen Yao et al.   CELL

The Role of LGR4 (GPR48) in Normal and Cancer Processes

(2021) Alejandro Ordaz-Ramos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of R-spondins/Lgrs in development of movable craniofacial organs

(2021) Jun Nihara et al.   GENE EXPRESSION PATTERNS

The fornix acts as a permissive corridor for septal neuron migration beyond the diencephalic-telencephalic boundary

(2020) Keisuke Watanabe et al.   Scientific Reports

R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors

(2020) Valerie PI Vidal et al.   eLife

Temporally Distinct Roles for the Zinc Finger Transcription Factor Sp8 in the Generation and Migration of Dorsal Lateral Ganglionic Eminence (dLGE)-Derived Neuronal Subtypes in the Mouse

(2020) J Kuerbitz et al.   CEREBRAL CORTEX

Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin

(2019) Sean J. Miller et al.   NATURE NEUROSCIENCE

The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation

(2018) Daniel Gyllborg et al.   Stem Cell Reports

Wnt signalling in the development of axon, dendrites and synapses

(2018) Chun-Wei He et al.   Open Biology

LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

(2016) Jian Luo et al.   NATURE MEDICINE

Antagonistic negative and positive neurons of the basolateral amygdala

(2016) Joshua Kim et al.   NATURE NEUROSCIENCE

The cortical hem regulates the size and patterning of neocortex

(2014) Giuliana Caronia-Brown et al.   DEVELOPMENT

R-spondins/Lgrs expression in tooth development

(2014) Maiko kawasaki et al.   DEVELOPMENTAL DYNAMICS

The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength

(2014) W. de Lau et al.   GENES & DEVELOPMENT

Lgr4 is a key regulator of prostate development and prostate stem cell differentiation

(2013) Weijia Luo et al.   STEM CELLS

LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor

(2012) Xing Gong et al.   PLoS One

The R-spondin protein family

(2012) Wim BM de Lau et al.   GENOME BIOLOGY

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

(2011) Roxana C Mustata et al.   EMBO REPORTS

LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling

(2011) Andrei Glinka et al.   EMBO REPORTS

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/ -catenin signaling

(2011) K. S. Carmon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental Origin of the Neuronal Subtypes That Comprise the Amygdalar Fear Circuit in the Mouse

(2010) R. R. Waclaw et al.   JOURNAL OF NEUROSCIENCE

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

(2010) H. J. Snippert et al.   SCIENCE

R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis

(2008) S. M. Bell et al.   DEVELOPMENT