Pazopanib ameliorates rotenone-induced Parkinsonism in rats by suppressing multiple regulated cell death mechanisms

Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease

(2023) Heba M. Mansour et al.   AGEING RESEARCH REVIEWS

Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease

(2023) Heba M. Mansour et al.   European Journal of Pharmacology

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1

(2022) Zong Miao et al.   Cell Death & Disease

PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity

(2022) Guang Lei et al.   Cancer Communications

Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease

(2022) Nancy K. El-Deeb et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effects of Hsp90 inhibitor on the RIP1-RIP3-MLKL pathway during the development of heart failure in mice

(2021) Tetsuro Marunouchi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson’s disease in rats: Possible role of endocannabinoid system modulation

(2021) Aya Yassin Labib et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism

(2021) Soumitra Ghosh et al.   PROGRESS IN NEUROBIOLOGY

Potential Repositioning of Anti-cancer EGFR Inhibitors in Alzheimer’s Disease: Current Perspectives and Challenging Prospects

(2021) Heba M. Mansour et al.   NEUROSCIENCE

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

(2021) Qingyun Tan et al.   Frontiers in Pharmacology

Repurposed anti-cancer epidermal growth factor receptor inhibitors: mechanisms of neuroprotective effects in Alzheimer’s disease

(2021) MahmoudM Khattab et al.   Neural Regeneration Research

Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90‐Client Interactions

(2020) Giorgio Colombo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group

(2019) Gregory L. Hamilton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement–Induced Parkinson’s Disease in Experimental Rats

(2019) Shakshi Sharma et al.   NEUROTOXICITY RESEARCH

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

(2019) Liam Gracia et al.   Frontiers in Neuroscience

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

(2018) Ngala Elvis Mbiydzenyuy et al.   BMC NEUROSCIENCE

Repurposing anticancer drugs for targeting necroptosis

(2018) Simone Fulda   CELL CYCLE

Necroptosis: a regulated inflammatory mode of cell death

(2018) Yogesh K. Dhuriya et al.   Journal of Neuroinflammation

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons

(2018) Sarah Kishinevsky et al.   Nature Communications

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Oxidative stress and cellular pathologies in Parkinson’s disease

(2017) Lesly Puspita et al.   Molecular Brain

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antiferroptotic activity of non-oxidative dopamine

(2016) Ding Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulated cell death and adaptive stress responses

(2016) Lorenzo Galluzzi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells

(2016) Zhirui Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

(2016) Haidy E. Michel et al.   MOLECULAR NEUROBIOLOGY

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulated necrosis: disease relevance and therapeutic opportunities

(2016) Marcus Conrad et al.   NATURE REVIEWS DRUG DISCOVERY

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis

(2016) X M Zhao et al.   Cell Death & Disease

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

(2016) Laurence Booth et al.   Oncotarget

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

(2015) Dianrong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

(2015) A Fauster et al.   Cell Death & Disease

Mechanisms for redox-regulation of protein kinase C

(2015) Susan F. Steinberg   Frontiers in Pharmacology

Exenatide as a potential treatment for patients with Parkinson's disease: First steps into the clinic

(2014) Thomas Foltynie et al.   Alzheimers & Dementia

Disease duration and the integrity of the nigrostriatal system in Parkinson’s disease

(2013) Jeffrey H. Kordower et al.   BRAIN

Targeting tyrosine-kinases in ovarian cancer

(2013) Matteo Morotti et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Protein kinase C, an elusive therapeutic target?

(2012) Daria Mochly-Rosen et al.   NATURE REVIEWS DRUG DISCOVERY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Recent Advances in Small Molecule Inhibitors of VEGFR and EGFR Signaling Pathways

(2011) Haizhen Zhong et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A rotarod test for evaluation of motor skill learning

(2010) Hiromi Shiotsuki et al.   JOURNAL OF NEUROSCIENCE METHODS

(Pre-)Clinical Pharmacology and Activity of Pazopanib, a Novel Multikinase Angiogenesis Inhibitor

(2010) P. Hamberg et al.   ONCOLOGIST

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

New developments in Hsp90 inhibitors as anti-cancer therapeutics: Mechanisms, clinical perspective and more potential

(2009) Yanyan Li et al.   DRUG RESISTANCE UPDATES

The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein

(2009) S. Fabio Falsone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model

(2009) Victor Tapias et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

(2008) L. Wang et al.   JOURNAL OF NEUROSCIENCE

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Protection by the NDI1 Gene against Neurodegeneration in a Rotenone Rat Model of Parkinson's Disease

(2008) Mathieu Marella et al.   PLoS One