Lapatinib ditosylate rescues motor deficits in rotenone-intoxicated rats: Potential repurposing of anti-cancer drug as a disease-modifying agent in Parkinson's disease

Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease

(2023) Heba M. Mansour et al.   AGEING RESEARCH REVIEWS

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

(2022) Hai-Liang Zhang et al.   NATURE CELL BIOLOGY

Optimization of measurement of mitochondrial electron transport activity in postmortem human brain samples and measurement of susceptibility to rotenone and 4-hydroxynonenal inhibition

(2022) Gloria A. Benavides et al.   Redox Biology

Anti-Inflammatory Effect of Resveratrol Derivatives via the Downregulation of Oxidative-Stress-Dependent and c-Src Transactivation EGFR Pathways on Rat Mesangial Cells

(2022) I-Ta Lee et al.   Antioxidants

PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity

(2022) Guang Lei et al.   Cancer Communications

Alzheimer's and Parkinson's disease therapies in the clinic

(2022) Puja Chopade et al.   Bioengineering & Translational Medicine

Crosstalk between PI3K/AKT/KLF4 signaling and microglia M1/M2 polarization as a novel mechanistic approach towards flibanserin repositioning in parkinson's disease

(2022) Nancy K. El-Deeb et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipid Peroxides Mediated Ferroptosis in Electromagnetic Pulse-Induced Hippocampal Neuronal Damage via Inhibition of GSH/GPX4 Axis

(2022) Yunfei Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In-silico studies of glutathione peroxidase4 activators as candidate for multiple sclerosis management

(2022) Alaa Alnoor Alameen et al.   Journal of Saudi Chemical Society

Targeting ferroptosis: Paving new roads for drug design and discovery

(2022) Yilin Gu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells

(2021) Xin Liu et al.   Frontiers in Molecular Neuroscience

Lapatinib ditosylate rescues memory impairment in D-galactose/ovariectomized rats: Potential repositioning of an anti-cancer drug for the treatment of Alzheimer's disease

(2021) Heba M. Mansour et al.   EXPERIMENTAL NEUROLOGY

Protein Lipoxidation: Basic Concepts and Emerging Roles

(2021) Álvaro Viedma-Poyatos et al.   Antioxidants

Oxidative stress and regulated cell death in Parkinson’s disease

(2021) P.A. Dionísio et al.   AGEING RESEARCH REVIEWS

Mechanistic insights into the protective effect of paracetamol against rotenone-induced Parkinson’s disease in rats: Possible role of endocannabinoid system modulation

(2021) Aya Yassin Labib et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism

(2021) Soumitra Ghosh et al.   PROGRESS IN NEUROBIOLOGY

LRRK2 recruitment, activity, and function in organelles

(2021) Luis Bonet‐Ponce et al.   FEBS Journal

Src family kinases (SFKs): critical regulators of microglial homeostatic functions and neurodegeneration in Parkinson's and Alzheimer's disease

(2021) Camila C. Portugal et al.   FEBS Journal

Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

(2021) Yue Zhou et al.   Oxidative Medicine and Cellular Longevity

Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases

(2021) Qingyun Tan et al.   Frontiers in Pharmacology

Binding Mechanism between Acetylcholinesterase and Drugs Pazopanib and Lapatinib: Biochemical and Biophysical Studies

(2021) Thaís Meira Menezes et al.   ACS Chemical Neuroscience

Inhibition of mitochondrial pyruvate carrier 1 by lapatinib ditosylate mitigates Alzheimer's-like disease in D-galactose/ovariectomized rats

(2021) Heba M. Mansour et al.   NEUROCHEMISTRY INTERNATIONAL

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

(2021) Chih-Jan Ko et al.   Biomedicines

Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson’s Disease Models

(2020) Hanyu Yang et al.   Frontiers in Neuroscience

Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90‐Client Interactions

(2020) Giorgio Colombo et al.   CHEMISTRY-A EUROPEAN JOURNAL

The dual role of c‐src in cell‐to‐cell transmission of α‐synuclein

(2020) Yu Ree Choi et al.   EMBO REPORTS

Metformin protects rotenone-induced dopaminergic neurodegeneration by reducing lipid peroxidation

(2020) Gul Ozbey et al.   Pharmacological Reports

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Metabotropic signaling cascade involved in α4β2 nicotinic acetylcholine receptor-mediated PKCβII activation

(2020) Srijan Acharya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Lapatinib Activates the Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 Pathway in HepG2 Cells

(2020) Noëmi Johanna Roos et al.   Frontiers in Pharmacology

The glutathione system in Parkinson’s disease and its progression

(2020) Geir Bjørklund et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

FTH1 Inhibits Ferroptosis Through Ferritinophagy in the 6-OHDA Model of Parkinson’s Disease

(2020) Ye Tian et al.   Neurotherapeutics

Neuroprotective Effects of the Anti-cancer Drug Lapatinib Against Epileptic Seizures via Suppressing Glutathione Peroxidase 4-Dependent Ferroptosis

(2020) Ji-Ning Jia et al.   Frontiers in Pharmacology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Inhibitors of Oxidative Phosphorylation Modulate Astrocyte Inflammatory Responses through AMPK-Dependent Ptgs2 mRNA Stabilization

(2019) Alina Astakhova et al.   Cells

Neuroprotective Effect of Quercetin in Combination with Piperine Against Rotenone- and Iron Supplement–Induced Parkinson’s Disease in Experimental Rats

(2019) Shakshi Sharma et al.   NEUROTOXICITY RESEARCH

Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases

(2019) Liam Gracia et al.   Frontiers in Neuroscience

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

(2018) Ngala Elvis Mbiydzenyuy et al.   BMC NEUROSCIENCE

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

(2018) Ting Li et al.   Journal of Hematology & Oncology

Live or let die: Neuroprotective and anti-cancer effects of nutraceutical antioxidants

(2018) Xiao-Yuan Mao et al.   PHARMACOLOGY & THERAPEUTICS

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Targeting Nrf2 to Suppress Ferroptosis and Mitochondrial Dysfunction in Neurodegeneration

(2018) Moataz Abdalkader et al.   Frontiers in Neuroscience

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

Ferroptosis and cell death mechanisms in Parkinson's disease

(2017) Stephanie J. Guiney et al.   NEUROCHEMISTRY INTERNATIONAL

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Antioxidants Mediate Both Iron Homeostasis and Oxidative Stress

(2017) Mustapha Imam et al.   Nutrients

Nrf2-Keap1 pathway promotes cell proliferation and diminishes ferroptosis

(2017) Z Fan et al.   Oncogenesis

Transcriptional Regulation by Nrf2

(2017) Claudia Tonelli et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1

(2016) Biao Wang et al.   CANCER LETTERS

The Endocytic Fate of the Transferrin Receptor Is Regulated by c-Abl Kinase

(2016) Hong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Parkinson’s Disease Drug Candidate with Potent Anti-neuroinflammatory Effects through the Src Signaling Pathway

(2016) Ya-Dan Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson’s disease and its progression: Disease and staging biomarkers and new drug targets

(2016) Carine Coneglian de Farias et al.   NEUROSCIENCE LETTERS

Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells

(2016) S Ma et al.   Cell Death & Disease

The 5-Lipoxygenase Inhibitor Zileuton Confers Neuroprotection against Glutamate Oxidative Damage by Inhibiting Ferroptosis

(2015) Yang Liu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Src Tyrosine Kinase Activation by 4-Hydroxynonenal Upregulates p38, ERK/AP-1 Signaling and COX-2 Expression in YPEN-1 Cells

(2015) Eun Ji Jang et al.   PLoS One

The Neuroprotective Role of Ferrostatin-1 Under Rotenone-Induced Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2015) Parijat Kabiraj et al.   PROTEIN JOURNAL

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

(2015) Diana M. Dunn et al.   Cell Reports

Lapatinib concentration in cerebrospinal fluid in two patients with HER2-positive metastatic breast cancer and brain metastases

(2014) S. Gori et al.   ANNALS OF ONCOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

(2014) John D. Hayes et al.   TRENDS IN BIOCHEMICAL SCIENCES

HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer

(2014) R Schulz et al.   Cell Death & Disease

Hsp90 Inhibits α-Synuclein Aggregation by Interacting with Soluble Oligomers

(2013) Soumya Daturpalli et al.   JOURNAL OF MOLECULAR BIOLOGY

Silencing of Hsp90 Chaperone Expression Protects Against 6-Hydroxydopamine Toxicity in PC12 Cells

(2013) Behrang Alani et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system

(2013) Sigrun Polier et al.   Nature Chemical Biology

Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review

(2013) Sandeep K. Vishwakarma et al.   Journal of Advanced Research

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A Synopsis on the Role of Tyrosine Hydroxylase in Parkinson’s Disease

(2012) Shams Tabrez et al.   CNS & Neurological Disorders-Drug Targets

Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain

(2011) Frederick P Bellinger et al.   Molecular Neurodegeneration

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

(2010) Kyung Mi Lee et al.   BIOCHEMICAL PHARMACOLOGY

Catechols in post-mortem brain of patients with Parkinson disease

(2010) D. S. Goldstein et al.   EUROPEAN JOURNAL OF NEUROLOGY

A rotarod test for evaluation of motor skill learning

(2010) Hiromi Shiotsuki et al.   JOURNAL OF NEUROSCIENCE METHODS

Iron elevations in the aging Parkinsonian brain: a consequence of impaired iron homeostasis?

(2009) Donna W. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin treatment potentiates neurodegeneration in a rat rotenone Parkinson's disease model

(2009) Victor Tapias et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Parkinson's disease

(2009) Andrew J Lees et al.   LANCET

The Chaperone Activity of Heat Shock Protein 90 Is Critical for Maintaining the Stability of Leucine-Rich Repeat Kinase 2

(2008) L. Wang et al.   JOURNAL OF NEUROSCIENCE