In vitro screening technologies for the discovery and development of novel drugs against Toxoplasma gondii

Synthesis and Antiparasitic Activity of New Trithiolato-Bridged Dinuclear Ruthenium(II)-arene-carbohydrate Conjugates

(2023) Isabelle Holzer et al.   MOLECULES

Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis

(2023) Matthew A. Hulverson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Toxoplasma gondii infection: novel emerging therapeutic targets

(2023) Joachim Müller et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline-O-Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites

(2023) Jessica Ramseier et al.   Pathogens

Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

(2022) Yawei Du et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Current practice in the management of ocular toxoplasmosis

(2022) Kengadhevi Yogeswaran et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Toxoplasmosis in Zoo Animals: A Retrospective Pathology Review of 126 Cases

(2022) Daniela Denk et al.   Animals

Structural Insight into Effective Inhibitors’ Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase

(2022) Jarunee Vanichtanankul et al.   ACS Chemical Biology

Cerebral toxoplasmosis in HIV-infected patients: a review

(2022) Sofiati Dian et al.   Pathogens and Global Health

Evaluation of anti-parasitic activities of new quinolones containing nitrofuran moiety against Toxoplasma gondii

(2022) Mitra Sadeghi et al.   EXPERIMENTAL PARASITOLOGY

NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model

(2022) Laura Rico-San Román et al.   Pathogens

Toxoplasma gondii in Foods: Prevalence, Control, and Safety

(2022) Pablo-Jesús Marín-García et al.   Foods

Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin

(2022) Joachim Müller et al.   Biomedicines

Is the incidence of congenital toxoplasmosis declining?

(2022) Gregory Colin Milne et al.   TRENDS IN PARASITOLOGY

The determinants regulating Toxoplasma gondii bradyzoite development

(2022) Ming Pan et al.   Frontiers in Microbiology

Toxoplasma gondii seropositivity and cognitive function in adults with schizophrenia

(2022) Ivanka Veleva et al.   Schizophrenia Research: Cognition

Bilateral Macular Toxoplasmosis

(2022) Ogul E. Uner et al.   Ophthalmology Retina

Toxoplasma gondii infection and its implications within the central nervous system

(2021) Sumit K. Matta et al.   NATURE REVIEWS MICROBIOLOGY

Outbreaks of clinical toxoplasmosis in humans: five decades of personal experience, perspectives and lessons learned

(2021) Jitender P. Dubey   Parasites & Vectors

In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts

(2021) Dennis Imhof et al.   International Journal for Parasitology-Drugs and Drug Resistance

The search for disease-modifying agents in decompensated cirrhosis: From drug repurposing to drug discovery

(2021) Paolo Caraceni et al.   JOURNAL OF HEPATOLOGY

The quest of the best – A SAR study of trithiolato-bridged dinuclear Ruthenium(II)-Arene compounds presenting antiparasitic properties

(2021) Emilia Păunescu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii In Vitro and in Pregnant Mice Infected with T. gondii Oocysts

(2021) Jessica Ramseier et al.   MOLECULES

Activities of Endochin-Like Quinolones Against in vitro Cultured Besnoitia besnoiti Tachyzoites

(2020) Naja Eberhard et al.   Frontiers in Veterinary Science

Coumarin‐Tagged Dinuclear Trithiolato‐Bridged Ruthenium(II)‐Arene Complexes – Photophysical Properties and Antiparasitic Activity

(2020) Oksana Desiatkina et al.   CHEMBIOCHEM

Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

(2020) Ryan Choi et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals

(2020) Joachim Müller et al.   MOLECULES

Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

(2020) Pablo Winzer et al.   Microorganisms

Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294

(2020) Pablo Winzer et al.   Pathogens

Orally Bioavailable Endochin-like Quinolone Carbonate Ester Prodrug Reduces Toxoplasma gondii Brain Cysts

(2020) J Stone Doggett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The life-cycle of Toxoplasma gondii reviewed using animations

(2020) Márcia Attias et al.   Parasites & Vectors

Conjugates Containing Two and Three Trithiolato-Bridged Dinuclear Ruthenium(II)-Arene Units as In Vitro Antiparasitic and Anticancer Agents

(2020) Valentin Studer et al.   Pharmaceuticals

Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro

(2019) Aruna Shrestha et al.   International Journal for Parasitology-Drugs and Drug Resistance

In vitro treatment of Besnoitia besnoiti with the naphto-quinone buparvaquone results in marked inhibition of tachyzoite proliferation, mitochondrial alterations and rapid adaptation of tachyzoites to increased drug concentrations

(2018) Joachim Müller et al.   PARASITOLOGY

Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice

(2018) Ildiko Rita Dunay et al.   CLINICAL MICROBIOLOGY REVIEWS

High-content imaging assay to evaluate Toxoplasma gondii infection and proliferation: A multiparametric assay to screen new compounds

(2018) Bastien Touquet et al.   PLoS One

Targeted Structure–Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

(2018) Erin V. McConnell et al.   ACS Infectious Diseases

Extended-spectrum antiprotozoal bumped kinase inhibitors: A review

(2017) Wesley C. Van Voorhis et al.   EXPERIMENTAL PARASITOLOGY

In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum

(2017) Joachim Müller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites

(2017) Alejandro Jiménez-Meléndez et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis

(2017) Joachim Müller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

(2017) Yuxiang Dong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development in Assay Methods for in Vitro Antimalarial Drug Efficacy Testing: A Systematic Review

(2017) Shweta Sinha et al.   Frontiers in Pharmacology

The use of Gompertz models in growth analyses, and new Gompertz-model approach: An addition to the Unified-Richards family

(2017) Kathleen M. C. Tjørve et al.   PLoS One

In vitro observation of the stage conversion of transgenic Toxoplasma gondii RH strain expressing dual fluorescent proteins

(2016) Qijun Song et al.   ACTA PARASITOLOGICA

Drug target identification in protozoan parasites

(2016) Joachim Müller et al.   Expert Opinion on Drug Discovery

A systematic review and meta-analysis of the relative efficacy and safety of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimethoprim-sulfamethoxazole a real option?

(2016) AV Hernandez et al.   HIV MEDICINE

Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy

(2016) Kayode K. Ojo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Ocular Toxoplasmosis: an Update

(2016) J. Garweg   KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE

Development of dual fluorescent stage specific reporter strain of Toxoplasma gondii to follow tachyzoite and bradyzoite development in vitro and in vivo

(2016) T.C. Paredes-Santos et al.   MICROBES AND INFECTION

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Bumped kinase inhibitor prohibits egression in Babesia bovis

(2016) Monica J. Pedroni et al.   VETERINARY PARASITOLOGY

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

(2016) Wesley C. Van Voorhis et al.   PLoS Pathogens

Drug Repurposing Screening Identifies Novel Compounds That Effectively Inhibit Toxoplasma gondii Growth

(2016) Ashley J. Dittmar et al.   mSphere

In VitroandIn VivoEffects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum

(2015) Pablo Winzer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts

(2015) Joachim Müller et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Current Therapy of Acquired Ocular Toxoplasmosis: A Review

(2015) Guilherme Sturzeneker Cerqueira Lima et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice

(2015) Joachim Müller et al.   International Journal for Parasitology-Drugs and Drug Resistance

Microplate assay for screening Toxoplasma gondii bradyzoite differentiation with DUAL luciferase assay

(2014) Tatsuki Sugi et al.   ANALYTICAL BIOCHEMISTRY

Starvation of low-density lipoprotein-derived cholesterol induces bradyzoite conversion in Toxoplasma gondii

(2014) Fumiaki Ihara et al.   Parasites & Vectors

Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy

(2014) Kayode K. Ojo et al.   PLoS One

Ocular toxoplasmosis past, present and new aspects of an old disease

(2014) M. Maenz et al.   PROGRESS IN RETINAL AND EYE RESEARCH

High Throughput Screening for Anti–Trypanosoma cruzi Drug Discovery

(2014) Julio Alonso-Padilla et al.   PLoS Neglected Tropical Diseases

In VitroEffects of Novel Ruthenium Complexes in Neospora caninum and Toxoplasma gondii Tachyzoites

(2013) Fabienne Barna et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Determination of stage interconversion in vitro and in vivo by construction of transgenic Toxoplasma gondii that stably express stage-specific fluorescent proteins

(2013) Houshuang Zhang et al.   EXPERIMENTAL PARASITOLOGY

Dopamine Stimulates Propagation ofToxoplasma gondiiTachyzoites in Human Fibroblast and Primary Neonatal Rat Astrocyte Cell Cultures

(2013) Jeannine S. Strobl et al.   JOURNAL OF PARASITOLOGY

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Identification of mutations in TgMAPK1 of Toxoplasma gondii conferring resistance to 1NM-PP1

(2013) Tatsuki Sugi et al.   International Journal for Parasitology-Drugs and Drug Resistance

Epidemiology of and Diagnostic Strategies for Toxoplasmosis

(2012) F. Robert-Gangneux et al.   CLINICAL MICROBIOLOGY REVIEWS

Simple and efficient model systems of screening anti-Toxoplasmadrugsin vitro

(2012) Chunmei Jin et al.   Expert Opinion on Drug Discovery

The Revised Classification of Eukaryotes

(2012) Sina M. Adl et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity

(2012) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Di-cationic arylimidamides act against Neospora caninum tachyzoites by interference in membrane structure and nucleolar integrity and are active against challenge infection in mice

(2012) Michelle Schorer et al.   International Journal for Parasitology-Drugs and Drug Resistance

Identification of Tissue Cyst Wall Components by Transcriptome Analysis of In Vivo and In Vitro Toxoplasma gondii Bradyzoites

(2011) Kerry R. Buchholz et al.   EUKARYOTIC CELL

The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures

(2011) CHRISTIAN KROPF et al.   PARASITOLOGY

Toxoplasma tachyzoites from cell culture are more appropriate in some situations

(2010) J. M. W. Chatterton et al.   JOURNAL OF CLINICAL PATHOLOGY

Thiazole, Oxadiazole, and Carboxamide Derivatives of Artemisinin are Highly Selective and Potent Inhibitors ofToxoplasma gondii

(2010) Christopher P. Hencken et al.   JOURNAL OF MEDICINAL CHEMISTRY

Apicoplast: keep it or leave it

(2010) Tobias Fleige et al.   MICROBES AND INFECTION

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

(2010) Kayode K Ojo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Toxoplasma gondii: determinants of tachyzoite to bradyzoite conversion

(2010) Sini Skariah et al.   PARASITOLOGY RESEARCH

Toxoplasma gondii Lysine Acetyltransferase GCN5-A Functions in the Cellular Response to Alkaline Stress and Expression of Cyst Genes

(2010) Arunasalam Naguleswaran et al.   PLoS Pathogens

Toxoplasma gondii Cyst Wall Formation in Activated Bone Marrow-derived Macrophages and Bradyzoite Conditions

(2010) Crystal Tobin et al.   Jove-Journal of Visualized Experiments

Phenotypic and Gene Expression Changes among Clonal Type I Strains ofToxoplasma gondii

(2009) Asis Khan et al.   EUKARYOTIC CELL

Psychosis may be associated with toxoplasmosis

(2009) Sha Zhu   MEDICAL HYPOTHESES

Toxoplasma and schizophrenia

(2009) R. H. YOLKEN et al.   PARASITE IMMUNOLOGY

Visualization of Toxoplasma gondii stage conversion by expression of stage-specific dual fluorescent proteins

(2009) A. UNNO et al.   PARASITOLOGY

Ovine toxoplasmosis

(2009) ELISABETH A. INNES et al.   PARASITOLOGY

Toxoplasmosis in sheep—The last 20 years

(2009) J.P. Dubey   VETERINARY PARASITOLOGY

Targeting the Transcriptional and Translational Machinery of the Endosymbiotic Organelle in Apicomplexans

(2008) Tobias Fleige et al.   CURRENT DRUG TARGETS

A new combined flow-cytometry-based assay reveals excellent activity against Toxoplasma gondii and low toxicity of new bisphosphonates in vitro and in vivo

(2008) H. M. Shubar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Primary Culture of Skeletal Muscle Cells as a Model for Studies of Toxoplasma gondii Cystogenesis

(2008) Erick Vaz Guimarães et al.   JOURNAL OF PARASITOLOGY

Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: A novel class of anti-parasitic compounds

(2008) Joachim Müller et al.   PARASITOLOGY INTERNATIONAL

The differential protein expression profiles and immunogenicity of tachyzoites and bradyzoites of in vitro cultured Neospora caninum

(2008) Seung-Won Kang et al.   PARASITOLOGY RESEARCH

The differentiation of transcription between tachyzoites and bradyzoites of in vitro cultured Neospora caninum

(2008) Seung-Won Kang et al.   PARASITOLOGY RESEARCH

Construction of Toxoplasma gondii bradyzoite expressing the green fluorescent protein

(2007) Yoshifumi Nishikawa et al.   PARASITOLOGY INTERNATIONAL