Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance

A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites

(2020) Jakob Birnbaum et al.   SCIENCE

Dimeric artesunate phospholipid-conjugated liposomes as promising anti-inflammatory therapy for rheumatoid arthritis

(2020) Yaru Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

(2020) Aline Uwimana et al.   NATURE MEDICINE

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion

(2020) Carlo Giannangelo et al.   PLoS Pathogens

A Temporizing Solution to “Artemisinin Resistance”

(2019) Jigang Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Determinants of dihydroartemisinin-piperaquine treatment failure in Plasmodium falciparum malaria in Cambodia, Thailand, and Vietnam: a prospective clinical, pharmacological, and genetic study

(2019) Rob W van der Pluijm et al.   LANCET INFECTIOUS DISEASES

Ozonide Antimalarial Activity in the Context of Artemisinin-Resistant Malaria

(2019) Carlo Giannangelo et al.   TRENDS IN PARASITOLOGY

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

(2019) Tuo Yang et al.   Cell Reports

Redox-sensitive dimeric camptothecin phosphatidylcholines-based liposomes for improved anticancer efficacy

(2019) Wei He et al.   Nanomedicine

Liposomes of dimeric artesunate phospholipid: A combination of dimerization and self-assembly to combat malaria

(2018) Muhammad Ismail et al.   BIOMATERIALS

Dimeric camptothecin derived phospholipid assembled liposomes with high drug loading for cancer therapy

(2018) Shuo Fang et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway

(2018) Daniel Hughes et al.   FEBS Journal

Chloroquine and nanoparticle drug delivery: A promising combination

(2018) Joe Pelt et al.   PHARMACOLOGY & THERAPEUTICS

Adapting liposomes for oral drug delivery

(2018) Haisheng He et al.   Acta Pharmaceutica Sinica B

Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome

(2018) Jessica L. Bridgford et al.   Nature Communications

Multi-omics Based Identification of Specific Biochemical Changes Associated With PfKelch13-Mutant Artemisinin-Resistant Plasmodium falciparum

(2017) Ghizal Siddiqui et al.   JOURNAL OF INFECTIOUS DISEASES

Galactose-Anchored Gelatin Nanoparticles for Primaquine Delivery and Improved Pharmacokinetics: A Biodegradable and Safe Approach for Effective Antiplasmodial Activity against P. falciparum 3D7 and in Vivo Hepatocyte Targeting

(2017) Hitesh Kumar et al.   MOLECULAR PHARMACEUTICS

A thiol probe for measuring unfolded protein load and proteostasis in cells

(2017) Moore Z. Chen et al.   Nature Communications

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains

(2016) Tuo Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study

(2016) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stability of the Antimalarial Drug Dihydroartemisinin under Physiologically Relevant Conditions: Implications for Clinical Treatment and Pharmacokinetic andIn VitroAssays

(2015) Silvia Parapini et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Strategy to provide a useful solution to effective delivery of dihydroartemisinin: Development, characterization and in vitro studies of liposomal formulations

(2014) Chiara Righeschi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins

(2014) Stanley C. Xie et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Malaria

(2013) Nicholas J White et al.   LANCET

Malaria and artemisinin derivatives: an updated review

(2013) Muhammad Ansari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Site-specific protein labeling using PRIME and chelation-assisted click chemistry

(2013) Chayasith Uttamapinant et al.   Nature Protocols

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An important role of intramolecular free radical reactions in antimalarial activity of artemisinin and its analogs

(2011) Evgeny Denisov   ORGANIC & BIOMOLECULAR CHEMISTRY

Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies

(2010) Jian Li et al.   MOLECULES

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Probing the Antimalarial Mechanism of Artemisinin and OZ277 (Arterolane) with Nonperoxidic Isosteres and Nitroxyl Radicals

(2009) M. A. Fugi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Stability of Peroxide Antimalarials in the Presence of Human Hemoglobin

(2009) D. J. Creek et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Major pitfalls in the measurement of artemisinin derivatives in plasma in clinical studies

(2008) N. Lindegardh et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES