Low dose of levetiracetam counteracts amyloid β-induced alterations of hippocampal gamma oscillations by restoring fast-spiking interneuron activity

Effect of Levetiracetam on Cognition in Patients With Alzheimer Disease With and Without Epileptiform Activity

(2021) Keith Vossel et al.   JAMA Neurology

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

(2020) Martí Colom-Cadena et al.   Alzheimers Research & Therapy

Inhibitory parvalbumin basket cell activity is selectively reduced during hippocampal sharp wave ripples in a mouse model of familial Alzheimer’s disease

(2020) Adam Caccavano et al.   JOURNAL OF NEUROSCIENCE

Modulation of Kv3.1/Kv3.2 promotes gamma oscillations by rescuing Aβ‐induced desynchronization of fast‐spiking interneuron firing in an AD mouse model in vitro

(2020) Yuniesky Andrade‐Talavera et al.   JOURNAL OF PHYSIOLOGY-LONDON

Response of spike-wave discharges in aged APP/PS1 Alzheimer model mice to antiepileptic, metabolic and cholinergic drugs

(2020) Nanxiang Jin et al.   Scientific Reports

A randomized controlled trial measuring changes in cerebral blood flow after levetiracetam in patients with Alzheimer’s disease

(2020) Christian Sandøe Musaeus et al.   Alzheimers & Dementia

Entrainment of gamma oscillations by auditory chirp stimulation in Alzheimer’s disease patients

(2020) Mohammad Javad Sedghizadeh et al.   Alzheimers & Dementia

Synaptic vesicle protein SV2A imaging with [11C]UCB‐J as a novel biomarker of neurodegeneration in Alzheimer's disease

(2020) Barbara B Bendlin et al.   Alzheimers & Dementia

Reduced firing rates of pyramidal cells in the frontal cortex of APP/PS1 can be restored by acute treatment with levetiracetam

(2020) Jan L. Klee et al.   NEUROBIOLOGY OF AGING

Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer’s disease amyloidosis

(2019) Jan-Oliver Hollnagel et al.   PLoS One

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

(2019) Kerstin Heurling et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

(2019) Chinnakkaruppan Adaikkan et al.   NEURON

Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities

(2019) Chinnakkaruppan Adaikkan et al.   TRENDS IN NEUROSCIENCES

Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer’s Disease

(2018) Magdalena Martinez-Losa et al.   NEURON

Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging

(2018) Ming-Kai Chen et al.   JAMA Neurology

Gamma oscillations in cognitive disorders

(2018) Alexandra J Mably et al.   CURRENT OPINION IN NEUROBIOLOGY

Hippocampal GABAergic Neurons are Susceptible to Amyloid-β Toxicity in vitro and are Decreased in Number in the Alzheimer's Disease TgCRND8 Mouse Model

(2018) Slavica Krantic et al.   JOURNAL OF ALZHEIMERS DISEASE

TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

(2018) Hugo Balleza-Tapia et al.   eLife

A randomized, double-blind, placebo-controlled crossover study of the effects of levetiracetam on cognition, mood, and balance in healthy older adults

(2017) Mike R. Schoenberg et al.   EPILEPSIA

Levetiracetam Alters Oscillatory Connectivity in Alzheimer’s Disease

(2017) Christian S. Musaeus et al.   JOURNAL OF ALZHEIMERS DISEASE

Phenotypic Alterations in Hippocampal NPY- and PV-Expressing Interneurons in a Presymptomatic Transgenic Mouse Model of Alzheimer’s Disease

(2017) Ian Mahar et al.   Frontiers in Aging Neuroscience

Emergence of early alterations in network oscillations and functional connectivity in a tau seeding mouse model of Alzheimer’s disease pathology

(2017) A. Ahnaou et al.   Scientific Reports

Short-Term Effects of Rhythmic Sensory Stimulation in Alzheimer’s Disease: An Exploratory Pilot Study

(2016) Amy Clements-Cortes et al.   JOURNAL OF ALZHEIMERS DISEASE

Network abnormalities and interneuron dysfunction in Alzheimer disease

(2016) Jorge J. Palop et al.   NATURE REVIEWS NEUROSCIENCE

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies

(2015) Irene Sola et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Mouse Model of Alzheimer’s

(2014) Per Nilsson et al.   ACS Chemical Neuroscience

Inhibitory Interneuron Progenitor Transplantation Restores Normal Learning and Memory in ApoE4 Knock-In Mice without or with A  Accumulation

(2014) L. M. Tong et al.   JOURNAL OF NEUROSCIENCE

Antiepileptics Topiramate and Levetiracetam Alleviate Behavioral Deficits and Reduce Neuropathology in APPswe/PS1dE9 Transgenic Mice

(2013) Jian-Quan Shi et al.   CNS Neuroscience & Therapeutics

Effects of levetiracetam, an antiepileptic drug, on memory impairments associated with aging and Alzheimer’s disease in mice

(2013) Latha Devi et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation

(2013) Mihály Hajós et al.   Frontiers in Pharmacology

Reduction of Hippocampal Hyperactivity Improves Cognition in Amnestic Mild Cognitive Impairment

(2012) Arnold Bakker et al.   NEURON

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

(2012) P. E. Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levetiracetam, lamotrigine, and phenobarbital in patients with epileptic seizures and Alzheimer’s disease

(2010) Eduardo Cumbo et al.   EPILEPSY & BEHAVIOR

Parvalbumin-Containing Fast-Spiking Basket Cells Generate the Field Potential Oscillations Induced by Cholinergic Receptor Activation in the Hippocampus

(2010) A. I. Gulyas et al.   JOURNAL OF NEUROSCIENCE