IL-18 serves as a main effector of CAF-derived METTL3 against immunosuppression of NSCLC via driving NF-κB pathway

HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer

(2022) Yingke Zhou et al.   Theranostics

JNK Signaling Promotes Bladder Cancer Immune Escape by Regulating METTL3-Mediated m6A Modification of PD-L1 mRNA

(2022) Zegui Ni et al.   CANCER RESEARCH

Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

(2022) Jia Xiong et al.   MOLECULAR CELL

Immune‑related genes and gene sets for predicting the response to anti‑programmed death 1 therapy in patients with primary or metastatic non‑small cell lung cancer

(2021) Bolin Chen et al.   Oncology Letters

Long non‑coding RNA SLC25A25‑AS1 exhibits oncogenic roles in non‑small cell lung cancer by regulating the microRNA‑195‑5p/ITGA2 axis

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Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

(2020) Floriane Pelon et al.   Nature Communications

Mechanistic insights into m6A modification of U6 snRNA by human METTL16

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Regulation of heterogeneous cancer-associated fibroblasts: the molecular pathology of activated signaling pathways

(2020) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy

(2020) Ting Zhou et al.   NATURE

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

(2020) Chengwu Zeng et al.   Journal of Hematology & Oncology

The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells

(2020) Deobrat Dixit et al.   Cancer Discovery

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma

(2019) Ting Li et al.   Molecular Cancer

GFPT2-expressing cancer-associated fibroblasts mediate metabolic reprogramming in human lung adenocarcinoma

(2018) Weiruo Zhang et al.   CANCER RESEARCH

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System

(2018) Mauro P. Avanzi et al.   Cell Reports

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway

(2018) Xiaocheng Zhou et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phosphorylated RB Promotes Cancer Immunity by Inhibiting NF-κB Activation and PD-L1 Expression

(2018) Xin Jin et al.   MOLECULAR CELL

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing

(2018) Michael Bartoschek et al.   Nature Communications

PD-L1 expression in advanced NSCLC: Insights into risk stratification and treatment selection from a systematic literature review

(2017) Robert Brody et al.   LUNG CANCER

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Tumor-derived IL-18 induces PD-1 expression on immunosuppressive NK cells in triple-negative breast cancer

(2017) In Hae Park et al.   Oncotarget

Effect of interferon-γ on NF-κB and cytokine IL-18 and IL-27 in acute pancreatitis

(2017) Hongbo Meng et al.   Bosnian Journal of Basic Medical Sciences

Interleukin 18 (IL-18) as a target for immune intervention

(2016) Sebastian Wawrocki et al.   ACTA BIOCHIMICA POLONICA

Interleukin-27 rs153109 polymorphism and the risk of non-small-cell lung cancer in a Chinese population

(2016) Gangfeng Xiao et al.   OncoTargets and Therapy

The interleukin-18 gene promoter -607 A/C polymorphism contributes to non-small-cell lung cancer risk in a Chinese population

(2016) Youchao Jia et al.   OncoTargets and Therapy

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Long non-coding RNAs in non-small cell lung cancer as biomarkers and therapeutic targets

(2014) Jing Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

T Cell Receptor Signals to NF- B Are Transmitted by a Cytosolic p62-Bcl10-Malt1-IKK Signalosome

(2014) S. Paul et al.   Science Signaling

m6A mRNA Methylation: A New Circadian Pacesetter

(2013) Michael H. Hastings   CELL