IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Authors
Keywords
-
Journal
NATURE
Volume 583, Issue 7817, Pages 609-614
Publisher
Springer Science and Business Media LLC
Online
2020-06-25
DOI
10.1038/s41586-020-2422-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
- (2019) Sema Kurtulus et al. IMMUNITY
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- (2019) Brian C. Miller et al. NATURE IMMUNOLOGY
- Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
- (2019) Alberto Mantovani et al. IMMUNITY
- Inherited IL-18BP deficiency in human fulminant viral hepatitis
- (2019) Serkan Belkaya et al. JOURNAL OF EXPERIMENTAL MEDICINE
- TOX is a critical regulator of tumour-specific T cell differentiation
- (2019) Andrew C. Scott et al. NATURE
- TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
- (2019) Hyungseok Seo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection
- (2019) William H. Hudson et al. IMMUNITY
- Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment
- (2018) Kyohei Nakamura et al. CANCER CELL
- Integrating single-cell transcriptomic data across different conditions, technologies, and species
- (2018) Andrew Butler et al. NATURE BIOTECHNOLOGY
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy
- (2018) Matthew M. Gubin et al. CELL
- UV-induced somatic mutations elicit a functional T cell response in the YUMMER1.7 mouse melanoma model
- (2017) Jake Wang et al. Pigment Cell & Melanoma Research
- Cytokines in Cancer Immunotherapy
- (2017) Thomas A. Waldmann Cold Spring Harbor Perspectives in Biology
- Resistance to checkpoint blockade therapy through inactivation of antigen presentation
- (2017) Moshe Sade-Feldman et al. Nature Communications
- Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18
- (2017) Biliang Hu et al. Cell Reports
- A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells
- (2016) Meromit Singer et al. CELL
- Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18
- (2016) Z. Ma et al. CLINICAL CANCER RESEARCH
- Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition
- (2016) Hélène Salmon et al. IMMUNITY
- Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
- (2016) I. Tirosh et al. SCIENCE
- Insights into Cytokine–Receptor Interactions from Cytokine Engineering
- (2015) Jamie B. Spangler et al. Annual Review of Immunology
- Consensus nomenclature for CD8+T cell phenotypes in cancer
- (2015) Lionel Apetoh et al. OncoImmunology
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Cytokine therapy reverses NK cell anergy in MHC-deficient tumors
- (2014) Michele Ardolino et al. JOURNAL OF CLINICAL INVESTIGATION
- IL-2: The First Effective Immunotherapy for Human Cancer
- (2014) S. A. Rosenberg JOURNAL OF IMMUNOLOGY
- The IL-18 Antagonist IL-18-Binding Protein Is Produced in the Human Ovarian Cancer Microenvironment
- (2013) G. Carbotti et al. CLINICAL CANCER RESEARCH
- Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation
- (2013) J Adam Best et al. NATURE IMMUNOLOGY
- Cytokine-induced cytokine production by conventional and innate lymphoid cells
- (2012) Liying Guo et al. TRENDS IN IMMUNOLOGY
- IL-18 Induces PD-1-Dependent Immunosuppression in Cancer
- (2011) M. Terme et al. CANCER RESEARCH
- Essential role of the Wnt pathway effector Tcf-1 for the establishment of functional CD8 T cell memory
- (2010) G. Jeannet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A phase 2, randomized study of SB-485232, rhIL-18, in patients with previously untreated metastatic melanoma
- (2009) Ahmad A. Tarhini et al. CANCER
- Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
- (2009) Luca Gattinoni et al. NATURE MEDICINE
- A Dose-Escalation Study of Recombinant Human Interleukin-18 Using Two Different Schedules of Administration in Patients with Cancer
- (2008) M. J. Robertson et al. CLINICAL CANCER RESEARCH
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started