Learning from Safe-by-Design for Safe-and-Sustainable-by-Design: Mapping the Current Landscape of Safe-by-Design Reviews, Case Studies, and Frameworks

Development of a Benefit Assessment Matrix for Nanomaterials and Nano-enabled Products—Toward Safe and Sustainable by Design

(2023) Hyunjoo Hong et al.   Sustainability

The State of the Art and Challenges of In Vitro Methods for Human Hazard Assessment of Nanomaterials in the Context of Safe-by-Design

(2023) Nienke Ruijter et al.   Nanomaterials

TRAAC framework to improve regulatory acceptance and wider usability of tools and methods for safe innovation and sustainability of manufactured nanomaterials

(2023) Neeraj Shandilya et al.   NanoImpact

Preliminary Toxicological Analysis in a Safe-by-Design and Adverse Outcome Pathway-Driven Approach on Different Silver Nanoparticles: Assessment of Acute Responses in A549 Cells

(2023) Giulia Motta et al.   Toxics

Data-Driven Quantitative Intrinsic Hazard Criteria for Nanoproduct Development in a Safe-by-Design Paradigm: A Case Study of Silver Nanoforms

(2023) Irini Furxhi et al.   ACS Applied Nano Materials

Safe and sustainable by design: A computer-based approach to redesign chemicals for reduced environmental hazards

(2022) Joanke van Dijk et al.   CHEMOSPHERE

Outside the Safe Operating Space of the Planetary Boundary for Novel Entities

(2022) Linn Persson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Scientific concepts and methods for moving persistence assessments into the 21st century

(2022) Russell Davenport et al.   Integrated Environmental Assessment and Management

Safe(r) by design guidelines for the nanotechnology industry

(2022) Araceli Sánchez Jiménez et al.   NanoImpact

Flavonoids as biopesticides – Systematic assessment of sources, structures, activities and environmental fate

(2022) Lena Schnarr et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Safe(r) by design in the nanotechnology sector

(2022) Araceli Sánchez Jiménez et al.   NanoImpact

Combined Application of the Essential-Use and Functional Substitution Concepts: Accelerating Safer Alternatives

(2022) Monika A. Roy et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Re-designing environmentally persistent pharmaceutical pollutant through programmed inactivation: The case of methotrexate

(2022) Anaïs Espinosa et al.   CHEMOSPHERE

Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings

(2022) V. Cazzagon et al.   Frontiers in Bioengineering and Biotechnology

Approaches to implement safe by design in early product design through combining risk assessment and Life Cycle Assessment

(2022) Vrishali Subramanian et al.   CHEMOSPHERE

Designing benign molecules: The influence of O-acetylated glucosamine-substituents on the environmental biodegradability of fluoroquinolones

(2022) Stefanie Lorenz et al.   CHEMOSPHERE

Towards more Sustainable Peptide- based Antibiotics: Stable in Human Blood, Enzymatically Hydrolyzed in Wastewater?

(2021) Michael T. Zumstein et al.   CHIMIA

First Steps Toward Sustainable Circular Uses of Chemicals: Advancing the Assessment and Management Paradigm

(2021) Zhanyun Wang et al.   ACS Sustainable Chemistry & Engineering

Safe-by-Design in Engineering: An Overview and Comparative Analysis of Engineering Disciplines

(2021) Pieter van Gelder et al.   International Journal of Environmental Research and Public Health

Avoiding Regrettable Substitutions: Green Toxicology for Sustainable Chemistry

(2021) Alexandra Maertens et al.   ACS Sustainable Chemistry & Engineering

Reducing Environmental Pollution by Antibiotics through Design for Environmental Degradation

(2021) Christoph Leder et al.   ACS Sustainable Chemistry & Engineering

Integrative approach in a safe by design context combining risk, life cycle and socio-economic assessment for safer and sustainable nanomaterials

(2021) Beatrice Salieri et al.   NanoImpact

Surface Functionalization of Graphene‐Based Materials: Biological Behavior, Toxicology, and Safe‐By‐Design Aspects

(2021) Zhiling Guo et al.   Advanced Biology

Safe-by-Design part II: A strategy for balancing safety and functionality in the different stages of the innovation process

(2021) Isabella Tavernaro et al.   NanoImpact

Occupational risk of nano-biomaterials: Assessment of nano-enabled magnetite contrast agent using the BIORIMA Decision Support System

(2021) V. Cazzagon et al.   NanoImpact

Toward Rigorous Materials Production: New Approach Methodologies Have Extensive Potential to Improve Current Safety Assessment Practices

(2020) Penny Nymark et al.   Small

Adverse outcome pathways as a tool for the design of testing strategies to support the safety assessment of emerging advanced materials at the nanoscale

(2020) Sabina Halappanavar et al.   Particle and Fibre Toxicology

Size-Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe-by-Design

(2020) Artur Filipe Rodrigues et al.   Advanced Science

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept

(2020) Cíntia Marques et al.   Frontiers in Bioengineering and Biotechnology

A Methodological Safe-by-Design Approach for the Development of Nanomedicines

(2020) Mélanie Schmutz et al.   Frontiers in Bioengineering and Biotechnology

Safe‐by‐Design Exfoliation of Niobium Diselenide Atomic Crystals as a Theory‐Oriented 2D Nanoagent from Anti‐Inflammation to Antitumor

(2020) Zhaohua Miao et al.   ADVANCED FUNCTIONAL MATERIALS

Challenges of implementing nano-specific safety and safe-by-design principles in academia

(2020) Lya G. Soeteman-Hernández et al.   NanoImpact

Recent progress on cheminformatics approaches to epigenetic drug discovery

(2020) Zoe Sessions et al.   DRUG DISCOVERY TODAY

Safe by design implementation in the nanotechnology industry

(2020) Araceli Sánchez Jiménez et al.   NanoImpact

A framework for grouping and read-across of nanomaterials- supporting innovation and risk assessment

(2020) Vicki Stone et al.   Nano Today

Safety and Sustainability Nexus: A Review and Appraisal

(2019) Waqas Nawaz et al.   JOURNAL OF CLEANER PRODUCTION

Circular chemistry to enable a circular economy

(2019) Tom Keijer et al.   Nature Chemistry

A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines

(2019) Liang Yan et al.   ADVANCED MATERIALS

Guiding the development of sustainable nano-enabled products for the conservation of works of art: proposal for a framework implementing the Safe by Design concept

(2019) Elena Semenzin et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Toxicity of TiO2, ZnO, and SiO2 Nanoparticles in Human Lung Cells: Safe-by-Design Development of Construction Materials

(2019) Monika Remzova et al.   Nanomaterials

From a problem to a business opportunity-design of pharmaceuticals for environmental biodegradability

(2019) Klaus Kümmerer   Sustainable Chemistry and Pharmacy

Plug-In Safe-by-Design Nanoinorganic Antibacterials

(2019) Milan Gautam et al.   ACS Nano

3D-Printed Lab-on-a-Chip Diagnostic Systems-Developing a Safe-by-Design Manufacturing Approach

(2019) Panagiotis Karayannis et al.   Micromachines

Safe-by-Design Ligand-Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells

(2018) Małgorzata Wolska-Pietkiewicz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives

(2018) Danail Hristozov et al.   Nanotoxicology

Implementation of Safe-by-Design for Nanomaterial Development and Safe Innovation: Why We Need a Comprehensive Approach

(2018) Annette Kraegeloh et al.   Nanomaterials

Google Scholar, Web of Science, and Scopus: A systematic comparison of citations in 252 subject categories

(2018) Alberto Martín-Martín et al.   Journal of Informetrics

Airborne Nanoparticle Release and Toxicological Risk from Metal-Oxide-Coated Textiles: Toward a Multiscale Safe-by-Design Approach

(2017) Paride Mantecca et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Strategies to optimize the biocompatibility of iron oxide nanoparticles – “SPIONs safe by design”

(2017) Christina Janko et al.   JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

Integrate life-cycle assessment and risk analysis results, not methods

(2017) Igor Linkov et al.   Nature Nanotechnology

Safe-by-Design: from Safety to Responsibility

(2017) Ibo van de Poel et al.   NanoEthics

LICARA nanoSCAN - A tool for the self-assessment of benefits and risks of nanoproducts

(2016) Toon van Harmelen et al.   ENVIRONMENT INTERNATIONAL

The Right Tools for the Job: Evaluating Frameworks for Chemical Alternatives Assessment

(2016) Carrie Arnold   ENVIRONMENTAL HEALTH PERSPECTIVES

On the way to greener ionic liquids: identification of a fully mineralizable phenylalanine-based ionic liquid

(2016) Annette Haiß et al.   GREEN CHEMISTRY

A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies

(2016) Intan D.M. Azmi et al.   JOURNAL OF CONTROLLED RELEASE

Crystallographic facet-dependent stress responses by polyhedral lead sulfide nanocrystals and the potential “safe-by-design” approach

(2016) Yun Chang et al.   Nano Research

An Experimental and Computational Approach to the Development of ZnO Nanoparticles that are Safe by Design

(2016) Tu C. Le et al.   Small

Cheminformatic comparison of approved drugs from natural product versus synthetic origins

(2015) Christopher F. Stratton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Alternatives Assessment Frameworks: Research Needs for the Informed Substitution of Hazardous Chemicals

(2015) Molly M. Jacobs et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Review of Environmental Assessment Case Studies Blending Elements of Risk Assessment and Life Cycle Assessment

(2015) Robin Harder et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Advancing Safer Alternatives Through Functional Substitution

(2015) Joel A. Tickner et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Re-Designing of Existing Pharmaceuticals for Environmental Biodegradability: A Tiered Approach with β-Blocker Propranolol as an Example

(2015) Tushar Rastogi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Planetary boundaries: Guiding human development on a changing planet

(2015) W. Steffen et al.   SCIENCE

Toward substitution with no regrets

(2015) J. B. Zimmerman et al.   SCIENCE

Cytotoxicity and antibacterial activity of a new generation of nanoparticle-based consolidants for restoration and contribution to the safe-by-design implementation

(2015) Erik Tedesco et al.   TOXICOLOGY IN VITRO

A sustainable chemistry solution to the presence of pharmaceuticals and chemicals in the aquatic environment – the example of re-designing β-blocker Atenolol

(2015) Tushar Rastogi et al.   RSC Advances

A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells

(2014) Dania Movia et al.   BIOMATERIALS

Designing green derivatives of β-blocker Metoprolol: A tiered approach for green and sustainable pharmacy and chemistry

(2014) Tushar Rastogi et al.   CHEMOSPHERE

A strategy for grouping of nanomaterials based on key physico-chemical descriptors as a basis for safer-by-design NMs

(2014) Iseult Lynch et al.   Nano Today

Qualitative environmental risk assessment of photolytic transformation products of iodinated X-ray contrast agent diatrizoic acid

(2014) Tushar Rastogi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Toward the Development of Decision Supporting Tools That Can Be Used for Safe Production and Use of Nanomaterials

(2012) Claudia Som et al.   ACCOUNTS OF CHEMICAL RESEARCH

Incorporating environmental attributes into musk design

(2011) Robert S. Boethling   GREEN CHEMISTRY

Sustainable and safe design of footwear integrating ecological footprint and risk criteria

(2011) Marta Herva et al.   JOURNAL OF HAZARDOUS MATERIALS

The importance of life cycle concepts for the development of safe nanoproducts

(2009) Claudia Som et al.   TOXICOLOGY