Brain Neuropeptides, Neuroinflammation, and Irritable Bowel Syndrome

Medial prefrontal cortex oxytocin mitigates epilepsy and cognitive impairments induced by traumatic brain injury through reducing neuroinflammation in mice

(2023) Wen Chen et al.   Scientific Reports

Oxytocin acts centrally in the brain to improve leaky gut through the vagus nerve and a cannabinoid signaling in rats

(2022) Toshikatsu Okumura et al.   PHYSIOLOGY & BEHAVIOR

Central regulatory mechanisms of visceral sensation in response to colonic distension with special reference to brain orexin

(2021) Toshikatsu Okumura et al.   NEUROPEPTIDES

An enriched environment reduces chronic stress-induced visceral pain through modulating microglial activity in the central nucleus of the amygdala

(2021) Tian Yuan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ghrelin acts in the brain to block colonic hyperpermeability in response to lipopolysaccharide through the vagus nerve

(2020) Masatomo Ishioh et al.   NEUROPHARMACOLOGY

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

(2020) Hyuk Sung Kwon et al.   Translational Neurodegeneration

Intestinal barrier dysfunction following traumatic brain injury

(2019) Pengfei Pan et al.   NEUROLOGICAL SCIENCES

Systemic administration of orexin A ameliorates established experimental autoimmune encephalomyelitis by diminishing neuroinflammation

(2019) Laurine Becquet et al.   Journal of Neuroinflammation

Leaky gut: mechanisms, measurement and clinical implications in humans

(2019) Michael Camilleri   GUT

The endotoxin hypothesis of neurodegeneration

(2019) Guy C. Brown   Journal of Neuroinflammation

Ghrelin Attenuates Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis Involving NLRP3 Inflammasome Signaling Pathway and Pyroptosis

(2019) Fei Liu et al.   Frontiers in Pharmacology

Brain orexin improves intestinal barrier function via the vagal cholinergic pathway

(2019) Toshikatsu Okumura et al.   NEUROSCIENCE LETTERS

Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats

(2018) Toshikatsu Okumura et al.   BRAIN RESEARCH

Chronic stress-associated visceral hyperalgesia correlates with severity of intestinal barrier dysfunction

(2018) Amy L. Creekmore et al.   PAIN

Mucosal permeability and mast cells as targets for functional gastrointestinal disorders

(2018) Åsa V Keita et al.   CURRENT OPINION IN PHARMACOLOGY

High fat diet increases cognitive decline and neuroinflammation in a model of orexin loss

(2018) C.M. Duffy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Acyl ghrelin improves cognition, synaptic plasticity deficits and neuroinflammation following amyloid β (Aβ1-40) administration in mice

(2017) V. V. Santos et al.   JOURNAL OF NEUROENDOCRINOLOGY

Activation of corticotropin-releasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats

(2016) Gongliang Zhang et al.   BRAIN BEHAVIOR AND IMMUNITY

Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice

(2016) Lin Yuan et al.   Journal of Neuroinflammation

Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats

(2016) Toshikatsu Okumura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Hippocampal microglial activation and glucocorticoid receptor down-regulation precipitate visceral hypersensitivity induced by colorectal distension in rats

(2016) Gongliang Zhang et al.   NEUROPHARMACOLOGY

Irritable Bowel Syndrome Is Associated with an Increased Risk of Dementia: A Nationwide Population-Based Study

(2016) Chien-Hua Chen et al.   PLoS One

Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia

(2014) Mak Adam Daulatzai   NEUROCHEMICAL RESEARCH

Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation

(2013) Xiaoxing Xiong et al.   STROKE

The effects of oxytocin on social cognition and behaviour in frontotemporal dementia

(2011) Sarah Jesso et al.   BRAIN

Ghrelin: more than endogenous growth hormone secretagogue

(2010) Masayasu Kojima et al.   Annals of the New York Academy of Sciences