Article
Medicine, General & Internal
Junji Chen, Tadayuki Oshima, Xinyi Huang, Toshihiko Tomita, Hirokazu Fukui, Hiroto Miwa
Summary: This study evaluated the relationship between esophageal epithelial permeability, mast cell infiltration, IgG4 deposits, and chemokine levels in eosinophilic esophagitis (EoE) patients before and after treatment. The results showed that EoE patients had significantly increased esophageal epithelial infiltration of mast cells, IgG4 deposits, and permeability. Furthermore, different subsets of EoE patients showed distinct changes in the expression levels of chemokines after treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pathology
Nicole C. Panarelli, Jason L. Hornick, Rhonda K. Yantiss
Summary: Neoplastic and nonneoplastic mast cell disorders can cause gastrointestinal symptoms due to increased release of mast cell mediators. This review aims to provide pathologists with practical information on assessing mast cells in the gastrointestinal tract to help manage patients with presumed mast cell disorders.
Article
Cell Biology
Nobuhiro Nakano, Jiro Kitaura
Summary: Mucosal mast cells (MMCs) in the intestinal mucosa play a crucial role in the development of IgE-mediated food allergies. Recent research has revealed that MMCs are distinct from connective tissue mast cells found in the skin and other tissues. The mechanism of MMC expansion and their cellular functions are not well understood. Research focusing on MMCs can provide valuable insights into the underlying mechanisms of food allergies and advance their treatment.
Review
Nutrition & Dietetics
Valentina Giorgio, Gaia Margiotta, Giuseppe Stella, Federica Di Cicco, Chiara Leoni, Francesco Proli, Giuseppe Zampino, Antonio Gasbarrini, Roberta Onesimo
Summary: Functional gastrointestinal disorders (FGIDs) are common and impactful in children and young adults, but the role of diet in modifying intestinal permeability (IP) in pediatric FGIDs is not well understood. However, small dietary changes such as a low-FODMAP diet, adequate fiber intake, and modulation of gut microbiota through prebiotics and probiotics appear to lead to significant improvements in quality of life for FGID patients.
Review
Gastroenterology & Hepatology
Magdalini Mischopoulou, Mario D'Ambrosio, Elisabetta Bigagli, Cristina Luceri, Gianrico Farrugia, Gianluca Cipriani
Summary: This review focuses on the role of muscularis macrophages (MMs) in gastrointestinal function and their interaction with other cell types. It also highlights the critical role of mast cells in normal and diseased GI physiology.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Susrutha Puthanmadhom Narayanan, Daniel R. O'Brien, Mayank Sharma, Thomas C. Smyrk, Rondell P. Graham, Madhusudan Grover, Adil E. Bharucha
Summary: In patients with functional dyspepsia (FD), there is a modest reduction in the expression of several duodenal epithelial barrier proteins, possibly due to the up-regulation of regulatory miRNAs, along with increased small intestinal permeability measured in vivo.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hunter J. Friesen, John Rosen, Christina Low Kapalu, Meenal Singh, Tracy Spaeth, Jose T. Cocjin, Craig A. Friesen, Jennifer V. Schurman
Summary: In youth with rumination syndrome, there is an increase in eosinophil and mast cell densities in the gastric antrum, and an increase in intraepithelial lymphocytes in the duodenum. These changes appear to be independent of abdominal pain or early satiety.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Immunology
Tongqian Wu, Shirong Yan, Yu-Wen Yeh, Yu Fang, Zou Xiang
Summary: This study found that mast cells expressing only FcγRIIB or FcγRIIIA undergo caspase-independent apoptosis in response to IgG immune complex treatment. Lower frequencies of connective tissue mast cells (CTMC) were recorded in mice lacking either FcγRIIB or FcγRIIIA compared with wild-type mice, especially in aged mice. This suggests that FcγR-mediated mast cell apoptosis may explain the more robust persistence of CTMC compared to mucosal mast cells (MMC). The results were replicated in a mast cell engraftment model, ruling out possible confounding effects of mast cell recruitment or FcγR expression by other cells on mast cell number regulation.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Caterina Strisciuglio, Sabrina Cenni, Maria Rosaria Serra, Pasquale Dolce, Sanja Kolacek, Sara Sila, Ivana Trivic, Michal Rozenfeld Bar Lev, Raanan Shamir, Aco Kostovski, Alexandra Papadopoulou, Eleftheria Roma, Christina Katsagoni, Danijela Jojkic-Pavkov, Angelo Campanozzi, Elena Scarpato, Erasmo Miele, Annamaria Staiano
Summary: 《Mediterranean diet has a protective effect on functional gastrointestinal disorders》
Review
Gastroenterology & Hepatology
Mythili P. Pathipati, Eric D. Shah, Braden Kuo, Kyle D. Staller
Summary: This review evaluates the use of digital applications in managing functional gastrointestinal disorders, providing examples of relevant technologies and organizations. It also addresses the shortcomings of current treatment strategies and proposes potential solutions.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Chemistry, Multidisciplinary
James D. Byrne, Cameron C. Young, Jacqueline N. Chu, Jennifer Pursley, Mu Xian Chen, Adam J. Wentworth, Annie Feng, Ameya R. Kirtane, Kyla A. Remillard, Cindy I. Hancox, Mandar S. Bhagwat, Nicole Machado, Tiffany Hua, Siddartha M. Tamang, Joy E. Collins, Keiko Ishida, Alison Hayward, Sarah L. Becker, Samantha K. Edgington, Jonathan D. Schoenfeld, William R. Jeck, Chin Hur, Giovanni Traverso
Summary: The study demonstrates that 3D-printed GI radioprotective devices can significantly reduce crypt injury in a radiation proctitis rat model and confirm optimal device placement in a swine model. Dosimetric modeling shows a significant reduction in radiation dose to normal tissues in oral cavity cancer and prostate cancer patients with the use of the radioprotectant material.
Review
Biochemistry & Molecular Biology
Marcela Julio-Pieper, Alejandra Lopez-Aguilera, Johana Eyzaguirre-Velasquez, Loreto Olavarria-Ramirez, Claudia Ibacache-Quiroga, Javier A. Bravo, Gonzalo Cruz
Summary: This review summarizes recent evidence showing the significant effects of diet, gut microbiota and the enteric nervous system on supporting or impairing the mucosal barrier in the context of viral attack.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hiu Yan Lam, Vinay Tergaonkar, Alan Prem Kumar, Kwang Seok Ahn
Summary: Mast cells, as innate immune cells with unique features, play sentinel roles in response to rapid changes within their microenvironment and are increasingly recognized for their involvement in various pathophysiological processes, including COVID-19. This review highlights the emerging roles of mast cells in the pathogenesis of COVID-19 and the potential of mast cells as novel therapeutic targets for COVID-19 and other non-allergic inflammatory diseases.
Review
Biochemistry & Molecular Biology
Ansoo Lee, Hyunah Choo, Byungsun Jeon
Summary: Autism spectrum disorder is a group of neurodevelopmental disorders characterized by repetitive behaviors and difficulties with social interaction and communication. Existing drugs can alleviate some symptoms, but not the core symptoms. Serotonin receptors have emerged as potential therapeutic targets for ASD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Michel Bouchoucha, David Deutsch, Panha Uong, Florence Mary, Jean-Marc Sabate, Robert Benamouzig
Summary: The study found that overlap disorders are common in FGID patients, with most patients suffering from multiple disorders simultaneously. Patients with single FGID had higher BMI and rarely reported IBS, fecal incontinence, and anorectal pain. The clustering of patients with overlap FGIDs resulted in 23 subgroups, each significantly associated with specific disorders.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
J. P. Ganda Mall, L. Lofvendahl, C. M. Lindqvist, R. J. Brummer, A. V. Keita, I. Schoultz
SCIENTIFIC REPORTS
(2018)
Article
Gastroenterology & Hepatology
Maite Casado-Bedmar, Stephanie D. S. Heil, Par Myrelid, Johan D. Soderholm, Asa Keita
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Neuroimaging
Suzanne T. Witt, Olga Bednarska, Asa V. Keita, Adriane Icenhour, Michael P. Jones, Sigrid Elsenbruch, Johan D. Soderholm, Maria Engstrom, Emeran A. Mayer, Susanna Walter
NEUROIMAGE-CLINICAL
(2019)
Review
Cell Biology
Ida Schoultz, Asa V. Keita
Article
Gastroenterology & Hepatology
Amanda Thomson, Kathryn Smart, Michelle S. Somerville, Sarah N. Lauder, Gautham Appanna, James Horwood, Lawrence Sunder Raj, Brijesh Srivastava, Dharmaraj Durai, Martin J. Scurr, Asa V. Keita, Awen M. Gallimore, Andrew Godkin
BMC GASTROENTEROLOGY
(2019)
Article
Cell Biology
Ulrika Christerson, Asa Keita, Martin E. Winberg, Johan D. Soderholm, Christina Gustafson-Svard
Article
Gastroenterology & Hepatology
Asa Keita, Lina yYakmenko Alkaissi, Elin B. Holm, Stephanie D. S. Heil, Benoit Chassaing, Arlette Darfeuille-Michaud, Derek M. McKay, Johan D. Soderholm
JOURNAL OF CROHNS & COLITIS
(2020)
Article
Gastroenterology & Hepatology
Dorien Beeckmans, Ricard Farre, Danny Riethorst, Asa V. Keita, Patrick Augustijns, Johan D. Soederholm, Tim Vanuytsel, Hanne Vanheel, Jan Tack
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Article
Nutrition & Dietetics
John-Peter Ganda Mall, Frida Fart, Julia A. Sabet, Carl Marten Lindqvist, Ragnhild Nestestog, Finn Terje Hegge, Asa Keita, Robert J. Brummer, Ida Schoultz
Review
Cell Biology
Ida Schoultz, Asa V. Keita
Article
Gastroenterology & Hepatology
Felipe Meira de-Faria, Maite Casado-Bedmar, Carl Marten Lindqvist, Michael P. Jones, Susanna A. Walter, Asa V. Keita
Summary: The study suggests that the interaction between EGC and MC may contribute to the pathophysiology of IBS by affecting colonic permeability.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Cell Biology
Olga Biskou, Felipe Meira de-Faria, Susanna M. Walter, Martin E. Winberg, Staffan Haapaniemi, Par Myrelid, Johan D. Soderholm, Asa V. Keita
Summary: This study found the accumulation of EGC in the Peyer's patches of CD patients and discovered that EGC mediators can cause barrier dysfunction in CD patients. This suggests that EGC may have detrimental effects on the pathophysiology of CD.
Article
Gastroenterology & Hepatology
Linda Gerdin, Ana M. Gonzalez-Castro, Ann-Charlott Ericson, Mats Persborn, Javier Santos, Susanna A. Walter, Asa Keita, Maria Vicario, Johan D. Soderholm
Summary: This study investigates the effects of acute psychological stress on colorectal mucosal barrier function and molecular events in the rectal mucosa. The results suggest that stress increases paracellular permeability and modulates immune cell activity, potentially leading to gastrointestinal disorders. Further research is needed to understand the mechanisms of stress-mediated reduction in mucosal defensive activity and barrier dysfunction.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Maite Casado-Bedmar, Asa Keita
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2020)