Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner

Regulation of endoplasmic reticulum stress by hesperetin: Focus on antitumor and cytoprotective effects

(2022) Yaseen Hussain et al.   PHYTOMEDICINE

Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review

(2022) Md Sohel et al.   Heliyon

A Comparative Study of Hesperetin, Hesperidin and Hesperidin Glucoside: Antioxidant, Anti-Inflammatory, and Antibacterial Activities In Vitro

(2022) Sung-Sook Choi et al.   Antioxidants

The use of integrated text mining and protein-protein interaction approach to evaluate the effects of combined chemotherapeutic and chemopreventive agents in cancer therapy

(2022) Mohammad Rasoul Samandari Bahraseman et al.   PLoS One

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

(2021) Kah Min Yap et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Neuroprotective Properties of Quinone Reductase 2 Inhibitor M-11, a 2-Mercaptobenzimidazole Derivative

(2021) Mikhail V. Voronin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Natural Polyphenols Targeting Senescence: A Novel Prevention and Therapy Strategy for Cancer

(2020) Yan Bian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders

(2020) Amjad Khan et al.   Antioxidants

Comprehensive host-pathogen protein-protein interaction network analysis

(2020) Babak Khorsand et al.   BMC BIOINFORMATICS

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Targeting Autophagy in Cancer: Recent Advances and Future Directions

(2019) Ravi K. Amaravadi et al.   Cancer Discovery

Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer

(2018) Jing Xue et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Oxidative stress and neurodegeneration: The possible contribution of quinone reductase 2

(2018) Laure-Estelle Cassagnes et al.   FREE RADICAL BIOLOGY AND MEDICINE

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4

(2018) Cong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Acute telomere deprotection prevents ongoing BFB cycles and rampant instability in p16INK4a-deficient epithelial cells

(2018) Aina Bernal et al.   Oncotarget

S29434, a quinone reductase 2 inhibitor: main biochemical and cellular characterization

(2018) Jean A. Boutin et al.   MOLECULAR PHARMACOLOGY

Rutin, a Quercetin Glycoside, Restores Chemosensitivity in Human Breast Cancer Cells

(2017) Marcello Iriti et al.   PHYTOTHERAPY RESEARCH

Hesperetin and Naringenin sensitize HER2 positive cancer cells to death by serving as HER2 Tyrosine Kinase inhibitors

(2016) Bhavya Balan Chandrika et al.   LIFE SCIENCES

Computational protein–ligand docking and virtual drug screening with the AutoDock suite

(2016) Stefano Forli et al.   Nature Protocols

Paraptosis in the anti-cancer arsenal of natural products

(2016) Dongjoo Lee et al.   PHARMACOLOGY & THERAPEUTICS

Human cytoplasmic copper chaperones Atox1 and CCS exchange copper ions in vitro

(2015) Svenja Petzoldt et al.   BIOMETALS

Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest

(2015) Yaoxian Wang et al.   BMC CANCER

Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway

(2015) Shreyasi Palit et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species, ATP and calcium

(2015) Jixiang Zhang et al.   MEDICAL ONCOLOGY

Structural insights into the ligand-binding hot spots of APEX1: an in silico analysis

(2015) Pavithra K. Balasubramanian et al.   MEDICINAL CHEMISTRY RESEARCH

Hesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species

(2015) Dandan Wu et al.   TUMOR BIOLOGY

Curcumin Triggers p16-Dependent Senescence in Active Breast Cancer-Associated Fibroblasts and Suppresses Their Paracrine Procarcinogenic Effects

(2015) Siti-Fauziah Hendrayani et al.   NEOPLASIA

The differential susceptibilities of MCF-7 and MDA-MB-231 cells to the cytotoxic effects of curcumin are associated with the PI3K/Akt-SKP2-Cip/Kips pathway

(2014) Tao Jia et al.   Cancer Cell International

Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line

(2014) Sakineh Kazemi Noureini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation

(2013) Yusra Al Dhaheri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Autophagy, Apoptosis, Mitoptosis and Necrosis: Interdependence Between Those Pathways and Effects on Cancer

(2012) Wiem Chaabane et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Honokiol induces caspase-independent paraptosis via reactive oxygen species production that is accompanied by apoptosis in leukemia cells

(2012) Yao Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Three-Dimensional Structural Basis of Type II Hyperprolinemia

(2012) Dhiraj Srivastava et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities

(2009) Arup Maiti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: A model for identifying candidate breast-tumor suppressors

(2008) Helena Zientek-Targosz et al.   Molecular Cancer

Improving accuracy and efficiency of blind protein-ligand docking by focusing on predicted binding sites

(2008) Dario Ghersi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS