Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies

(2023) Maximilian J. Gerhardt et al.   Biomedicines

Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel

(2023) Diane C. A. Barret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational trajectory of allosteric gating of the human cone photoreceptor cyclic nucleotide-gated channel

(2023) Zhengshan Hu et al.   Nature Communications

Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel

(2022) Xiangdong Zheng et al.   Communications Biology

The structure of cyclic nucleotide-gated channels in rod and cone photoreceptors

(2022) Diane C.A. Barret et al.   TRENDS IN NEUROSCIENCES

NMR Structures of Calmodulin Bound to Two Separate Regulatory Sites in the Retinal Cyclic Nucleotide-Gated Channel

(2022) Aritra Bej et al.   BIOCHEMISTRY

Subunit promotion energies for channel opening in heterotetrameric olfactory CNG channels

(2022) Jana Schirmeyer et al.   PLoS Computational Biology

Anionic lipids unlock the gates of select ion channels in the pacemaker family

(2022) Philipp A. M. Schmidpeter et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel

(2022) Xiaolong Gao et al.   Nature Communications

Structural mechanisms of gating and selectivity of human rod CNGA1 channel

(2021) Jing Xue et al.   NEURON

Gating movements and ion permeation in HCN4 pacemaker channels

(2021) Andrea Saponaro et al.   MOLECULAR CELL

Thermodynamic profile of mutual subunit control in a heteromeric receptor

(2021) Jana Schirmeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional approaches to studying cAMP regulation of HCN channels

(2021) Andrea Saponaro et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure of the human cone photoreceptor cyclic nucleotide-gated channel

(2021) Xiangdong Zheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of the native CNGA1/CNGB1 CNG channel from bovine retinal rods

(2021) Diane C. A. Barret et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel

(2021) Jing Xue et al.   NEURON

Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels as Drug Targets for Neurological Disorders

(2020) Bina Santoro et al.   Annual Review of Pharmacology and Toxicology

Mechanism of ligand activation of a eukaryotic cyclic nucleotide−gated channel

(2020) Xiangdong Zheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The EAG Voltage-Dependent K+ Channel Subfamily: Similarities and Differences in Structural Organization and Gating

(2020) Francisco Barros et al.   Frontiers in Pharmacology

Functional characterization and optimization of a bacterial cyclic nucleotide–gated channel

(2019) Jacob L.W. Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Voltage Sensor Movements during Hyperpolarization in the HCN Channel

(2019) Chia-Hsueh Lee et al.   CELL

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ligand binding and activation properties of the purified bacterial cyclic nucleotide–gated channel SthK

(2018) Philipp A.M. Schmidpeter et al.   JOURNAL OF GENERAL PHYSIOLOGY

High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer

(2018) Julia Kowal et al.   STRUCTURE

Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures

(2018) Jan Rheinberger et al.   eLife

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel–associated retinopathy

(2018) Markus Burkard et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural insights into the mechanisms of CNBD channel function

(2017) Zachary M. James et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a eukaryotic cyclic-nucleotide-gated channel

(2017) Minghui Li et al.   NATURE

CryoEM structure of a prokaryotic cyclic nucleotide-gated ion channel

(2017) Zachary M. James et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Voltage-Gated Potassium Channels: A Structural Examination of Selectivity and Gating

(2016) Dorothy M. Kim et al.   Cold Spring Harbor Perspectives in Biology

Alternative Splicing Governs Cone Cyclic Nucleotide-gated (CNG) Channel Sensitivity to Regulation by Phosphoinositides

(2014) Gucan Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determinants of ligand selectivity in a cyclic nucleotide–regulated potassium channel

(2014) João Pessoa et al.   JOURNAL OF GENERAL PHYSIOLOGY

Family of prokaryote cyclic nucleotide-modulated ion channels

(2014) M. Brams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

(2014) Julia Kowal et al.   Nature Communications

Structural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels

(2013) Sven Schünke et al.   BIOLOGICAL CHEMISTRY

Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides

(2013) Gucan Dai et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Speed, adaptation, and stability of the response to light in cone photoreceptors: The functional role of Ca-dependent modulation of ligand sensitivity in cGMP-gated ion channels

(2011) Juan I. Korenbrot   JOURNAL OF GENERAL PHYSIOLOGY

Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels

(2011) Noah G. Shuart et al.   Nature Communications

Cooperative and uncooperative cyclic-nucleotide-gated ion channels

(2010) Abhishek Cukkemane et al.   TRENDS IN BIOCHEMICAL SCIENCES

Phototransduction Motifs and Variations

(2009) King-Wai Yau et al.   CELL

Mutations reveal voltage gating of CNGA1 channels in saturating cGMP

(2009) Juan Ramón Martínez-François et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain

(2008) Stephen L. Altieri et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the transmembrane regions of a bacterial cyclic nucleotide-regulated channel

(2008) G. M. Clayton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gating at the selectivity filter in cyclic nucleotide-gated channels

(2008) J. E. Contreras et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA