Variability of vaccine responsiveness in early life

Making human immune systems more interpretable through systems immunology

(2023) Rikard Forlin et al.   TRENDS IN IMMUNOLOGY

Very early life microbiome and metabolome correlates with primary vaccination variability in children

(2023) Michael Shaffer et al.   mSystems

Antibiotic Use and Vaccine Antibody Levels

(2022) Timothy J. Chapman et al.   PEDIATRICS

Transcriptional atlas of the human immune response to 13 vaccines reveals a common predictor of vaccine-induced antibody responses

(2022) Thomas Hagan et al.   NATURE IMMUNOLOGY

Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination

(2022) Emma M. de Koff et al.   Nature Communications

Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States

(2021) Giorgio Casaburi et al.   Scientific Reports

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

Bifidobacteria-mediated immune system imprinting early in life

(2021) Bethany M. Henrick et al.   CELL

The Impact of the Microbiome on Immunity to Vaccination in Humans

(2020) Sanne E. de Jong et al.   Cell Host & Microbe

Neonatal Exposure to Commensal-Bacteria-Derived Antigens Directs Polysaccharide-Specific B-1 B Cell Repertoire Development

(2020) J. Stewart New et al.   IMMUNITY

Immunologic dysfunction contributes to the otitis prone condition

(2020) Michael E. Pichichero   JOURNAL OF INFECTION

Mucosal or systemic microbiota exposures shape the B cell repertoire

(2020) Hai Li et al.   NATURE

Bifidobacterium Abundance in Early Infancy and Vaccine Response at 2 Years of Age

(2019) M. Nazmul Huda et al.   PEDIATRICS

Factors That Influence the Immune Response to Vaccination

(2019) Petra Zimmermann et al.   CLINICAL MICROBIOLOGY REVIEWS

Nonclassical Monocytes in Health and Disease

(2019) Prakash Babu Narasimhan et al.   Annual Review of Immunology

Antibiotics-Driven Gut Microbiome Perturbation Alters Immunity to Vaccines in Humans

(2019) Thomas Hagan et al.   CELL

Impact of delivery mode-associated gut microbiota dynamics on health in the first year of life

(2019) Marta Reyman et al.   Nature Communications

Rebooting Human Immunology

(2018) Mark M. Davis et al.   Annual Review of Immunology

Exploring the relationship between environmental enteric dysfunction and oral vaccine responses

(2018) James A Church et al.   Future Microbiology

Causes of impaired oral vaccine efficacy in developing countries

(2018) Edward PK Parker et al.   Future Microbiology

Ancient Nuclear Receptor VDR With New Functions: Microbiome and Inflammation

(2018) Danika Bakke et al.   INFLAMMATORY BOWEL DISEASES

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

(2018) Etienne Patin et al.   NATURE IMMUNOLOGY

Stereotypic Immune System Development in Newborn Children

(2018) Axel Olin et al.   CELL

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Homeostatic Immunity and the Microbiota

(2017) Yasmine Belkaid et al.   IMMUNITY

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny

(2017) Tobias R. Kollmann et al.   IMMUNITY

Reduced T-Helper 17 Responses to Streptococcus pneumoniae in Infection-Prone Children Can Be Rescued by Addition of Innate Cytokines

(2017) Saleem Basha et al.   JOURNAL OF INFECTIOUS DISEASES

Lithocholic acid controls adaptive immune responses by inhibition of Th1 activation through the Vitamin D receptor

(2017) Thijs W. H. Pols et al.   PLoS One

Continuous immunotypes describe human immune variation and predict diverse responses

(2017) Kevin J. Kaczorowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children

(2017) Dabin Ren et al.   VACCINE

Human CD39hi regulatory T cells present stronger stability and function under inflammatory conditions

(2016) Jian Gu et al.   Cellular & Molecular Immunology

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

Prospective study of the innate cellular immune response in low vaccine responder children

(2016) Naveen Surendran et al.   Innate Immunity

Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants

(2016) Michael E. Pichichero et al.   JOURNAL OF INFECTIOUS DISEASES

Significant Correlation Between the Infant Gut Microbiome and Rotavirus Vaccine Response in Rural Ghana

(2016) Vanessa C. Harris et al.   JOURNAL OF INFECTIOUS DISEASES

Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals

(2016) Li Liu et al.   LANCET

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

(2016) Olga Sobolev et al.   NATURE IMMUNOLOGY

The cellular composition of the human immune system is shaped by age and cohabitation

(2016) Edward J Carr et al.   NATURE IMMUNOLOGY

Neonatal gut microbiota associates with childhood multisensitized atopy and T cell differentiation

(2016) Kei E Fujimura et al.   NATURE MEDICINE

How colonization by microbiota in early life shapes the immune system

(2016) Thomas Gensollen et al.   SCIENCE

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Infants with low vaccine antibody responses have altered innate cytokine response

(2016) Naveen Surendran et al.   VACCINE

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

Development of Upper Respiratory Tract Microbiota in Infancy is Affected by Mode of Delivery

(2016) Astrid A.T.M. Bosch et al.   EBioMedicine

The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014

(2016) Ana Pilar Betrán et al.   PLoS One

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

(2015) Fredrik Bäckhed et al.   Cell Host & Microbe

Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children

(2015) S. Basha et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Systems Analysis of Immunity to Influenza Vaccination across Multiple Years and in Diverse Populations Reveals Shared Molecular Signatures

(2015) Helder I. Nakaya et al.   IMMUNITY

Biological challenges to effective vaccines in the developing world

(2015) N. C. Grassly et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Probiotics, antibiotics and the immune responses to vaccines

(2015) I. Praharaj et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Systems vaccinology: a promise for the young and the poor

(2015) N. Amenyogbe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Factors influencing innate immunity and vaccine responses in infancy

(2015) B. Kampmann et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

(2015) S. Yang et al.   SCIENCE

Utilizing population variation, vaccination, and systems biology to study human immunology

(2015) John S. Tsang   TRENDS IN IMMUNOLOGY

The infant microbiome development: mom matters

(2015) Noel T. Mueller et al.   TRENDS IN MOLECULAR MEDICINE

Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

(2015) Zachery T Lewis et al.   Microbiome

Involvement of the iNKT Cell Pathway Is Associated With Early-Onset Eosinophilic Esophagitis and Response to Allergen Avoidance Therapy

(2014) Willem S Lexmond et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Factors affecting immunogenicity of BCG in infants, a study in Malawi, The Gambia and the UK

(2014) Yun-Gyoung Hur et al.   BMC INFECTIOUS DISEASES

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

(2014) Laura M. Cox et al.   CELL

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Divergent mucosal and systemic responses in children in response to acute otitis media

(2014) D. Verhoeven et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential Impact of Respiratory Syncytial Virus and Parainfluenza Virus on the Frequency of Acute Otitis Media Is Explained by Lower Adaptive and Innate Immune Responses in Otitis-Prone Children

(2014) David Verhoeven et al.   CLINICAL INFECTIOUS DISEASES

Bile acids and the gut microbiome

(2014) Jason M. Ridlon et al.   CURRENT OPINION IN GASTROENTEROLOGY

Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis

(2014) Shaoping Wu et al.   GUT

TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

(2014) Jason Z. Oh et al.   IMMUNITY

Prenatal exposure to antibiotics, cesarean section and risk of childhood obesity

(2014) N T Mueller et al.   INTERNATIONAL JOURNAL OF OBESITY

Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut

(2014) Mark A. Underwood et al.   PEDIATRIC RESEARCH

Cesarean Section and Chronic Immune Disorders

(2014) A. Sevelsted et al.   PEDIATRICS

Stool Microbiota and Vaccine Responses of Infants

(2014) M. N. Huda et al.   PEDIATRICS

Medication Use in the Neonatal Intensive Care Unit

(2013) Emily Hsieh et al.   AMERICAN JOURNAL OF PERINATOLOGY

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months

(2013) M. B. Azad et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

(2013) Julia Cahenzli et al.   Cell Host & Microbe

Low gut microbiota diversity in early infancy precedes asthma at school age

(2013) T. R. Abrahamsson et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Cellular Immune Response in Young Children Accounts for Recurrent Acute Otitis Media

(2013) Sharad K. Sharma et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Major faecal microbiota shifts in composition and diversity with age in a geographically restricted cohort of mothers and their children

(2013) Ekaterina Avershina et al.   FEMS MICROBIOLOGY ECOLOGY

Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by Caesarean section

(2013) Hedvig E Jakobsson et al.   GUT

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

U.S. Outpatient Antibiotic Prescribing, 2010

(2013) Lauri A. Hicks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nonprotective Responses to Pediatric Vaccines Occur in Children Who Are Otitis Prone

(2013) Michael E. Pichichero et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

454 Pyrosequencing Analysis on Faecal Samples from a Randomized DBPC Trial of Colicky Infants Treated with Lactobacillus reuteri DSM 17938

(2013) Stefan Roos et al.   PLoS One

Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis

(2012) Chris Gale et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Functional deficits of pertussis-specific CD4+ T cells in infants compared to adults following DTaP vaccination

(2012) S. K. Sharma et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Infant B Cell Memory Differentiation and Early Gut Bacterial Colonization

(2012) A.-C. Lundell et al.   JOURNAL OF IMMUNOLOGY

Reduced Serum IgG Responses to Pneumococcal Antigens in Otitis-Prone Children May Be Due to Poor Memory B-Cell Generation

(2012) Sharad K. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Distinct Gut Microbiota in Southeastern African and Northern European Infants

(2012) Łukasz Grześkowiak et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

New Insights in Gut Microbiota Establishment in Healthy Breast Fed Neonates

(2012) Ted Jost et al.   PLoS One

Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses

(2011) Markus B. Geuking et al.   IMMUNITY

Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells

(2011) Isabelle C. Arnold et al.   JOURNAL OF CLINICAL INVESTIGATION

Reduced Memory CD4+ T-Cell Generation in the Circulation of Young Children May Contribute to the Otitis-Prone Condition

(2011) Sharad K. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

Unravelling the effects of the environment and host genotype on the gut microbiome

(2011) Aymé Spor et al.   NATURE REVIEWS MICROBIOLOGY

Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children

(2011) Ravinder Kaur et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Broad Conservation of Milk Utilization Genes in Bifidobacterium longum subsp. infantis as Revealed by Comparative Genomic Hybridization

(2010) R. G. LoCascio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides

(2010) David A. Sela et al.   TRENDS IN MICROBIOLOGY

Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children

(2010) Ravinder Kaur et al.   VACCINE

Microbial exposure, interferon gamma gene demethylation in naïve T-cells, and the risk of allergic disease

(2009) P. J. Vuillermin et al.   ALLERGY

Regulatory T Cells in Asthma

(2009) Clare M. Lloyd et al.   IMMUNITY

Breast-Feeding Is Associated With a Reduced Frequency of Acute Otitis Media and High Serum Antibody Levels Against NTHi and Outer Membrane Protein Vaccine Antigen Candidate P6

(2009) Albert Sabirov et al.   PEDIATRIC RESEARCH

Booster Vaccinations: Can Immunologic Memory Outpace Disease Pathogenesis?

(2009) M. E. Pichichero   PEDIATRICS

Yellow fever vaccine induces integrated multilineage and polyfunctional immune responses

(2008) Denis Gaucher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate immune recognition of the indigenous microbial flora

(2008) S Rakoff-Nahoum et al.   Mucosal Immunology

A microbial symbiosis factor prevents intestinal inflammatory disease

(2008) Sarkis K. Mazmanian et al.   NATURE

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

(2008) D. A. Sela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA