Integration of nuclear Ca2+ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression

Jacob‐induced transcriptional inactivation of CREB promotes Aβ‐induced synapse loss in Alzheimer's disease

(2023) Katarzyna M Grochowska et al.   EMBO JOURNAL

Protein transport from pre- and postsynapse to the nucleus: Mechanisms and functional implications

(2023) Maria Andres-Alonso et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

One-step purification of tag free and soluble lamin B1 from an E. coli bacterial expression system

(2022) Rajeev Raman et al.   PROTEIN EXPRESSION AND PURIFICATION

The nuclear lamina is a hub for the nuclear function of Jacob

(2021) Sebastian Samer et al.   Molecular Brain

The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health

(2021) Pawel Mozolewski et al.   JOURNAL OF CELL SCIENCE

Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression

(2021) Katarzyna M. Grochowska et al.   Frontiers in Synaptic Neuroscience

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

(2020) Rafael Alcalá‐Vida et al.   EMBO Molecular Medicine

Synapse-to-Nucleus Communication through NFAT Is Mediated by L-type Ca2+ Channel Ca2+ Spike Propagation to the Soma

(2019) Angela R. Wild et al.   Cell Reports

Fundamentals of Cellular Calcium Signaling: A Primer

(2019) Martin D. Bootman et al.   Cold Spring Harbor Perspectives in Biology

Genomic Decoding of Neuronal Depolarization by Stimulus-Specific NPAS4 Heterodimers

(2019) G. Stefano Brigidi et al.   CELL

In Vivo Imaging of the Coupling between Neuronal and CREB Activity in the Mouse Brain

(2019) Tal Laviv et al.   NEURON

Nuclear Lamins: Thin Filaments with Major Functions

(2018) Rebecca de Leeuw et al.   TRENDS IN CELL BIOLOGY

Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

(2017) Hilmar Bading   JOURNAL OF EXPERIMENTAL MEDICINE

CRTC1 mediates preferential transcription at neuronal activity-regulated CRE/TATA promoters

(2017) Arnaldo Parra-Damas et al.   Scientific Reports

Synaptonuclear messenger PRR7 inhibits c‐Jun ubiquitination and regulates NMDA‐mediated excitotoxicity

(2016) Dana O Kravchick et al.   EMBO JOURNAL

A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis

(2016) Christina Spilker et al.   PLoS Genetics

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

(2016) Margarita C Dinamarca et al.   eLife

Synaptic GluN2B/CaMKII-α Signaling Induces Synapto-Nuclear Transport of ERK and Jacob

(2016) Michelle Melgarejo da Rosa et al.   Frontiers in Molecular Neuroscience

Macromolecular transport in synapse to nucleus communication

(2015) Nicolas Panayotis et al.   TRENDS IN NEUROSCIENCES

The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A

(2015) Sairaam Ganesh et al.   Nucleus

The tail domain of lamin B1 is more strongly modulated by divalent cations than lamin A

(2015) Sairaam Ganesh et al.   Nucleus

Protein trafficking from synapse to nucleus in control of activity-dependent gene expression

(2014) R. Kaushik et al.   NEUROSCIENCE

The Regulation of Transcription in Memory Consolidation

(2014) Cristina M. Alberini et al.   Cold Spring Harbor Perspectives in Biology

Frequency decoding of calcium oscillations

(2013) Erik Smedler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain

(2013) Marina Mikhaylova et al.   Brain Structure & Function

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

(2013) Anna Karpova et al.   CELL

Nuclear Calcium Signaling in Spinal Neurons Drives a Genomic Program Required for Persistent Inflammatory Pain

(2013) Manuela Simonetti et al.   NEURON

HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

(2012) Richard Sando et al.   CELL

Activity-Dependent Transport of the Transcriptional Coactivator CRTC1 from Synapse to Nucleus

(2012) Toh Hean Ch'ng et al.   CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Nuclear Translocation of Jacob in Hippocampal Neurons after Stimuli Inducing Long-Term Potentiation but Not Long-Term Depression

(2011) Thomas Behnisch et al.   PLoS One

Biochemistry of calcium oscillations

(2010) Per Uhlén et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nuclear Calcium Sensors Reveal that Repetition of Trains of Synaptic Stimuli Boosts Nuclear Calcium Signaling in CA1 Pyramidal Neurons

(2010) C. Peter Bengtson et al.   BIOPHYSICAL JOURNAL

Mixed Microtubules Steer Dynein-Driven Cargo Transport into Dendrites

(2010) Lukas C. Kapitein et al.   CURRENT BIOLOGY

Genome–nuclear lamina interactions and gene regulation

(2010) Jop Kind et al.   CURRENT OPINION IN CELL BIOLOGY

An update on nuclear calcium signalling

(2009) M. D. Bootman et al.   JOURNAL OF CELL SCIENCE

Nucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling

(2009) Bryen A. Jordan et al.   TRENDS IN NEUROSCIENCES

Nuclear Calcium Signaling Controls Expression of a Large Gene Pool: Identification of a Gene Program for Acquired Neuroprotection Induced by Synaptic Activity

(2009) Sheng-Jia Zhang et al.   PLoS Genetics

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Frequency-modulated nuclear localization bursts coordinate gene regulation

(2008) Long Cai et al.   NATURE

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Calmodulin-Kinases: Modulators of Neuronal Development and Plasticity

(2008) Gary A. Wayman et al.   NEURON

Calcium Signaling in Dendrites and Spines: Practical and Functional Considerations

(2008) Michael J. Higley et al.   NEURON

Translating Neuronal Activity into Dendrite Elaboration: Signaling to the Nucleus

(2008) Lori Redmond   NEUROSIGNALS

Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models

(2008) Britt Mellström et al.   PHYSIOLOGICAL REVIEWS

Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons

(2008) T. Kawashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus

(2008) Daniela C Dieterich et al.   PLOS BIOLOGY

CREB/CBP and SRE-interacting transcriptional regulators are fast on-off switches: duration of calcium transients specifies the magnitude of transcriptional responses

(2003) Sangeeta Chawla et al.   JOURNAL OF NEUROCHEMISTRY