Synaptic GluN2B/CaMKII-α Signaling Induces Synapto-Nuclear Transport of ERK and Jacob

A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis

(2016) Christina Spilker et al.   PLoS Genetics

Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

(2016) Margarita C Dinamarca et al.   eLife

Macromolecular transport in synapse to nucleus communication

(2015) Nicolas Panayotis et al.   TRENDS IN NEUROSCIENCES

Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity

(2015) Sung-Soo Jang et al.   Molecular Brain

γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

(2014) Huan Ma et al.   CELL

Protein trafficking from synapse to nucleus in control of activity-dependent gene expression

(2014) R. Kaushik et al.   NEUROSCIENCE

Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

(2014) Guilherme Monteiro Gomes et al.   PLoS One

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins

(2014) Pingan Yuanxiang et al.   Jove-Journal of Visualized Experiments

Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain

(2013) Marina Mikhaylova et al.   Brain Structure & Function

Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus

(2013) Anna Karpova et al.   CELL

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

(2013) Pierre Paoletti et al.   NATURE REVIEWS NEUROSCIENCE

RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission

(2013) B. Schwechter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-Distance Integration of Nuclear ERK Signaling Triggered by Activation of a Few Dendritic Spines

(2013) S. Zhai et al.   SCIENCE

Interaction Between  CaMKII and GluN2B Controls ERK-Dependent Plasticity

(2012) F. El Gaamouch et al.   JOURNAL OF NEUROSCIENCE

Nuclear Translocation of Jacob in Hippocampal Neurons after Stimuli Inducing Long-Term Potentiation but Not Long-Term Depression

(2011) Thomas Behnisch et al.   PLoS One

Ras?ERK Signaling in Behavior: Old Questions and New Perspectives

(2011) Stefania Fasano et al.   Frontiers in Behavioral Neuroscience

The RasGrf family of mammalian guanine nucleotide exchange factors

(2010) Alberto Fernández-Medarde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Probing Intracellular Motor Protein Activity Using an Inducible Cargo Trafficking Assay

(2010) Lukas C. Kapitein et al.   BIOPHYSICAL JOURNAL

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the MajorN-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

(2010) Claudia Rauner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic Tagging and Capture: Differential Role of Distinct Calcium/Calmodulin Kinases in Protein Synthesis-Dependent Long-Term Potentiation

(2010) R. L. Redondo et al.   JOURNAL OF NEUROSCIENCE

Distinct Roles of NR2A and NR2B Cytoplasmic Tails in Long-Term Potentiation

(2010) K. A. Foster et al.   JOURNAL OF NEUROSCIENCE

Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

(2010) Raik Rönicke et al.   NEUROBIOLOGY OF AGING

Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation

(2010) F. Cai et al.   NEUROSCIENCE

Long-Term Potentiation in the CA1 Hippocampus Induced by NR2A Subunit-Containing NMDA Glutamate Receptors Is Mediated by Ras-GRF2/Erk Map Kinase Signaling

(2010) Shan-xue Jin et al.   PLoS One

Hippocampal NMDA receptor subunits differentially regulate fear memory formation and neuronal signal propagation

(2009) Can Gao et al.   HIPPOCAMPUS

Dendritic mRNA Targeting of Jacob andN-Methyl-d-aspartate-induced Nuclear Translocation after Calpain-mediated Proteolysis

(2009) Stefan Kindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling

(2009) Bryen A. Jordan et al.   TRENDS IN NEUROSCIENCES

Glutamate Transporters Regulate Extrasynaptic NMDA Receptor Modulation of Kv2.1 Potassium Channels

(2008) P. J. Mulholland et al.   JOURNAL OF NEUROSCIENCE

Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the Nucleus

(2008) Daniela C Dieterich et al.   PLOS BIOLOGY