CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling

(2023) Patricia Altea-Manzano et al.   Nature Cancer

A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

(2022) Catherine S. Blaha et al.   Nature Communications

AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3

(2021) Mathieu Paquette et al.   Autophagy

The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling

(2021) Milad J. Alasady et al.   PLoS One

Fatty acid mobilization from adipose tissue is mediated by CD36 posttranslational modifications and intracellular trafficking

(2021) Alexes C. Daquinag et al.   JCI Insight

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

(2021) Gloria Pascual et al.   NATURE

Low glycaemic diets alter lipid metabolism to influence tumour growth

(2021) Evan C. Lien et al.   NATURE

Endoplasmic Reticulum Stress Signaling in Cancer Cells

(2020) Scott A. Oakes   AMERICAN JOURNAL OF PATHOLOGY

Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer

(2020) Xinyu Chen et al.   MOLECULAR CELL

CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis

(2020) Jian-Wei Hao et al.   Nature Communications

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway

(2019) Yun Li et al.   JOURNAL OF LIPID RESEARCH

DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane

(2019) Juan Wang et al.   Cell Reports

Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

(2019) Kelsey Pinkham et al.   Stem Cell Reports

Suppressing fatty acid uptake has therapeutic effects in preclinical models of prostate cancer

(2019) Matthew J. Watt et al.   Science Translational Medicine

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids

(2019) Manuele Piccolis et al.   MOLECULAR CELL

Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation

(2019) Hyunju Cho et al.   Cell Reports

Real-time PCR quantification of spliced X-box binding protein 1 (XBP1) using a universal primer method

(2019) Seung-Bin Yoon et al.   PLoS One

The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC

(2019) Pablo E Hollstein et al.   Cancer Discovery

Stearoyl-CoA Desaturase 1 as a Therapeutic Target for the Treatment of Cancer

(2019) Zuzanna Tracz-Gaszewska et al.   Cancers

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

(2019) Christiaan F. Labuschagne et al.   Cell Metabolism

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Role of p38 MAPK in disease relapse and therapeutic resistance by maintenance of cancer stem cells in head and neck squamous cell carcinoma

(2018) Shomereeta Roy et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis

(2018) Andras Ladanyi et al.   ONCOGENE

Correlation of fatty acid receptor (CD36) positive circulating epithelial tumor cells (CETCs) with aggressiveness of breast cancer disease.

(2018) Dorothea Schott et al.   JOURNAL OF CLINICAL ONCOLOGY

Structural basis for regulation of human acetyl-CoA carboxylase

(2018) Moritz Hunkeler et al.   NATURE

Integrin α2β1 decelerates proliferation, but promotes survival and invasion of prostate cancer cells

(2018) Marjaana Ojalill et al.   Oncotarget

Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

(2018) Daniel Ackerman et al.   Cell Reports

Exogenous lipids promote the growth of breast cancer cells via CD36

(2017) Jing Zhao et al.   ONCOLOGY REPORTS

Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism

(2016) R. Ariel Igal   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice

(2016) Camella G. Wilson et al.   ENDOCRINOLOGY

AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550

(2016) Min Sung Joo et al.   MOLECULAR AND CELLULAR BIOLOGY

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis

(2015) Andreas Koeberle et al.   FASEB JOURNAL

The role of MAPK signalling pathways in the response to endoplasmic reticulum stress

(2014) Nicola J. Darling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Free Fatty Acid Uptake in Humans With CD36 Deficiency

(2014) Kazanna C. Hames et al.   DIABETES

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Herpesvirus-associated Ubiquitin-specific Protease (HAUSP) Modulates Peroxisome Proliferator-activated Receptor γ (PPARγ) Stability through Its Deubiquitinating Activity

(2013) Kyeong Won Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery

(2013) Jeevan Nagendran et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Stearoyl-CoA desaturase enzyme 1 inhibition reduces glucose utilization for de novo fatty acid synthesis and cell proliferation in 3T3-L1 adipocytes

(2013) Jennifer K. Yee et al.   Metabolomics

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids

(2013) J. J. Kamphorst et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis

(2012) Veronique Nogueira et al.   EMBO JOURNAL

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Activated AMPK inhibits PPAR-α and PPAR-γ transcriptional activity in hepatoma cells

(2011) Margaret S. Sozio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

(2009) Zachary T. Schafer et al.   NATURE

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements

(2008) Atsushi Maruyama et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS