Mycobacterium tuberculosis suppresses host DNA repair to boost its intracellular survival

Discovery of small-molecule inhibitors of RUVBL1/2 ATPase

(2022) Gang Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

CGAS is a micronucleophagy receptor for the clearance of micronuclei

(2021) Mengmeng Zhao et al.   Autophagy

Recent advances in γH2AX biomarker-based genotoxicity assays: A marker of DNA damage and repair

(2021) Nazanin Rahmanian et al.   DNA REPAIR

Foam Cell Macrophages in Tuberculosis

(2021) Pooja Agarwal et al.   Frontiers in Immunology

Interception of host fatty acid metabolism by mycobacteria under hypoxia to suppress anti-TB immunity

(2021) Hua Yang et al.   Cell Discovery

Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome

(2020) Savita Lochab et al.   eLife

New insights into the evasion of host innate immunity by Mycobacterium tuberculosis

(2020) Qiyao Chai et al.   Cellular & Molecular Immunology

Development of sulfonamide-based Schiff bases targeting urease inhibition: Synthesis, characterization, inhibitory activity assessment, molecular docking and ADME studies

(2020) Asad Hamad et al.   BIOORGANIC CHEMISTRY

The structure-based reaction mechanism of urease, a nickel dependent enzyme: tale of a long debate

(2020) Luca Mazzei et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

RUVBL1–RUVBL2 AAA-ATPase: a versatile scaffold for multiple complexes and functions

(2020) Maria I Dauden et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival

(2019) Dallas A. Banks et al.   JOURNAL OF IMMUNOLOGY

Validation of the γH2AX biomarker for genotoxicity assessment: a review

(2019) B. Kopp et al.   ARCHIVES OF TOXICOLOGY

Atenolol thiourea hybrid as potent urease inhibitors: Design, biology-oriented drug synthesis, inhibitory activity screening, and molecular docking studies

(2019) Sana Wahid et al.   BIOORGANIC CHEMISTRY

The Mycobacterium marinum ESX-1 system mediates phagosomal permeabilization and type I interferon production via separable mechanisms

(2019) Julia Lienard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferons in tuberculosis: Foe and occasionally friend

(2018) Lúcia Moreira-Teixeira et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mycobacterium tuberculosis promotes genomic instability in macrophages

(2018) Jorge Castro-Garza et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

(2018) Guoliang Zhang et al.   Nature Communications

Recent advances in design of new urease inhibitors: A review

(2018) Paweł Kafarski et al.   Journal of Advanced Research

Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

(2018) Joo Sang Lee et al.   CELL

Nuclear envelope assembly defects link mitotic errors to chromothripsis

(2018) Shiwei Liu et al.   NATURE

Oxidative DNA damage induced by ROS-modulating agents with the ability to target DNA: A comparison of the biological characteristics of citrus pectin and apple pectin

(2018) Fahimeh Salehi et al.   Scientific Reports

Mycobacterium tuberculosis–induced IFN-β production requires cytosolic DNA and RNA sensing pathways

(2018) Yong Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

(2018) Haipeng Liu et al.   NATURE

ROS and the DNA damage response in cancer

(2018) Upadhyayula Sai Srinivas et al.   Redox Biology

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas

(2016) Laura Herrtwich et al.   CELL

Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms

(2016) Marieke C.S. Boshuizen et al.   CYTOKINE

Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection

(2016) Mark R. Cronan et al.   IMMUNITY

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase

(2016) Ruchi Jain Dey et al.   Nature Chemical Biology

The Combination of X-Ray Crystallography and Cryo-Electron Microscopy Provides Insight into the Overall Architecture of the Dodecameric Rvb1/Rvb2 Complex

(2016) Noella Silva-Martin et al.   PLoS One

Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy

(2016) Caroline A. Ewens et al.   STRUCTURE

Mycobacterium tuberculosis EsxO (Rv2346c) promotes bacillary survival by inducing oxidative stress mediated genomic instability in macrophages

(2016) Soumitra Mohanty et al.   TUBERCULOSIS

Small molecule inhibits activity of scavenger receptor A: Lead identification and preliminary studies

(2015) Yunyun Yuan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

(2015) Robert O. Watson et al.   Cell Host & Microbe

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

(2015) Angela C. Collins et al.   Cell Host & Microbe

Removal of H2A.Z by INO80 promotes homologous recombination

(2015) H. E. Alatwi et al.   EMBO REPORTS

Immunoevasion and immunosuppression of the macrophage byMycobacterium tuberculosis

(2015) Zakaria Hmama et al.   IMMUNOLOGICAL REVIEWS

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

(2015) Bappaditya Dey et al.   NATURE MEDICINE

Host Evasion and Exploitation Schemes of Mycobacterium tuberculosis

(2014) C.J. Cambier et al.   CELL

Scavenger Receptor-A (CD204): A Two-Edged Sword in Health and Disease

(2014) Jim L. Kelley et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics

(2014) Anca Dorhoi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structure of Yin Yang 1 Oligomers That Cooperate with RuvBL1-RuvBL2 ATPases

(2014) Andrés López-Perrote et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocyte Activation from Interferon-α in HIV Infection Increases Acetylated LDL Uptake and ROS Production

(2014) Lynn Pulliam et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Interception of host angiogenic signalling limits mycobacterial growth

(2014) Stefan H. Oehlers et al.   NATURE

The Immune Response in Tuberculosis

(2013) Anne O'Garra et al.   Annual Review of Immunology

ROS inhibitorN-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors

(2013) Marianna Halasi et al.   BIOCHEMICAL JOURNAL

Proteomic Profiling ofMycobacterium tuberculosisIdentifies Nutrient-starvation-responsive Toxin–antitoxin Systems

(2013) Jakob Albrethsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Type I Interferon Suppresses Type II Interferon-Triggered Human Anti-Mycobacterial Responses

(2013) R. M. B. Teles et al.   SCIENCE

Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP

(2013) Liang-Dong Lyu et al.   PLoS Pathogens

Mycobacterium Tuberculosis Activates the DNA-Dependent Cytosolic Surveillance Pathway within Macrophages

(2012) Paolo S. Manzanillo et al.   Cell Host & Microbe

Mycobacterium tuberculosis-Driven Targeted Recalibration of Macrophage Lipid Homeostasis Promotes the Foamy Phenotype

(2012) Varshneya Singh et al.   Cell Host & Microbe

Role of macrophage scavenger receptors in atherosclerosis

(2012) Julia Kzhyshkowska et al.   IMMUNOBIOLOGY

Urease Activity Represents an Alternative Pathway for Mycobacterium tuberculosis Nitrogen Metabolism

(2012) Wenwei Lin et al.   INFECTION AND IMMUNITY

Conformational transitions regulate the exposure of a DNA-binding domain in the RuvBL1–RuvBL2 complex

(2012) Andrés López-Perrote et al.   NUCLEIC ACIDS RESEARCH

Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway

(2011) Gustavo A. de Souza et al.   Journal of Proteomics

Mycobacterium tuberculosis Uses Host Triacylglycerol to Accumulate Lipid Droplets and Acquires a Dormancy-Like Phenotype in Lipid-Loaded Macrophages

(2011) Jaiyanth Daniel et al.   PLoS Pathogens

Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: A novel link between interferon-α and atherosclerosis in lupus

(2010) Jia Li et al.   ARTHRITIS AND RHEUMATISM

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

RVB1/RVB2: Running Rings around Molecular Biology

(2009) Sudhakar Jha et al.   MOLECULAR CELL

Identification of ATPases Pontin and Reptin as Telomerase Components Essential for Holoenzyme Assembly

(2008) Andrew S. Venteicher et al.   CELL

RAD51 foci formation in response to DNA damage is modulated by TIP49

(2008) Anastas Gospodinov et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone

(2008) Daniel J. Smart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens