(B)On(e)-cohistones and the epigenetic alterations at the root of bone cancer

A knockout‐first model of H3f3a gene targeting leads to developmental lethality

(2023) Kelly Bush et al.   GENESIS

Genomic patterns of malignant peripheral nerve sheath tumor (MPNST) evolution correlate with clinical outcome and are detectable in cell-free DNA

(2023) Isidro Cortes-Ciriano et al.   Cancer Discovery

Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

(2023) Sima Khazaei et al.   CELL

Stalled oligodendrocyte differentiation in IDH-mutant gliomas

(2023) Yanfei Wei et al.   Genome Medicine

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

(2022) Alexandre de Nonneville et al.   EMBO Molecular Medicine

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

(2022) Lucia Cottone et al.   CELL DEATH AND DIFFERENTIATION

PRC2-indepdendent actions of H3.3K27M in embryonic stem cell differentiation

(2022) Lea R Z Cohen et al.   NUCLEIC ACIDS RESEARCH

A genetic model for central chondrosarcoma evolution correlates with patient outcome

(2022) William Cross et al.   Genome Medicine

Small round cell sarcomas

(2022) Florencia Cidre-Aranaz et al.   Nature Reviews Disease Primers

Loss of ATRX promotes aggressive features of osteosarcoma with increased NF-κB signaling and integrin binding

(2022) Suzanne Bartholf DeWitt et al.   JCI Insight

Histone variant H3 .3 promotes metastasis in alveolar rhabdomyosarcoma

(2022) Nandini Karthik et al.   JOURNAL OF PATHOLOGY

K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas

(2022) Selin Jessa et al.   NATURE GENETICS

Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

(2021) Raul Bardini Bressan et al.   Cell Stem Cell

Oncohistone mutations enhance chromatin remodeling and alter cell fates

(2021) John D. Bagert et al.   Nature Chemical Biology

Loci-specific phase separation of FET fusion oncoproteins promotes gene transcription

(2021) Linyu Zuo et al.   Nature Communications

Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

(2021) Brandon R Lowe et al.   eLife

Oncohistones: A Roadmap to Stalled Development

(2021) Shriya Deshmukh et al.   FEBS Journal

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

(2021) Lucille Stuani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploiting vulnerabilities of SWI/SNF chromatin remodelling complexes for cancer therapy

(2021) Marek Wanior et al.   ONCOGENE

Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

(2021) M. Udugama et al.   Nature Communications

The dark side of histones: genomic organization and role of oncohistones in cancer

(2021) Stefano Amatori et al.   Clinical Epigenetics

Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

(2021) Sinthu Pathmanapan et al.   Cancer & Metabolism

The implications of IDH mutations for cancer development and therapy

(2021) Christopher J. Pirozzi et al.   Nature Reviews Clinical Oncology

Serglycin induces osteoclastogenesis and promotes tumor growth in giant cell tumor of bone

(2021) Yunfei He et al.   Cell Death & Disease

Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

(2021) Amel Chaouch et al.   MOLECULAR CELL

Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

(2021) Julia P. Gerber et al.   NATURE CELL BIOLOGY

G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy

(2021) Mahmoud S. Alghamri et al.   Science Advances

Cell Biology of Giant Cell Tumour of Bone: Crosstalk between m/wt Nucleosome H3.3, Telomeres and Osteoclastogenesis

(2021) Ramses G. Forsyth et al.   Cancers

Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

(2020) Chan Chung et al.   CANCER CELL

Histone H3.3 phosphorylation amplifies stimulation-induced transcription

(2020) Anja Armache et al.   NATURE

Epigenetic Therapies for Cancer

(2020) Susan E. Bates   NEW ENGLAND JOURNAL OF MEDICINE

Sarcoma treatment in the era of molecular medicine

(2020) Thomas GP Grünewald et al.   EMBO Molecular Medicine

Drivers underpinning the malignant transformation of giant cell tumour of bone

(2020) Matthew W Fittall et al.   JOURNAL OF PATHOLOGY

H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

(2020) Siddhant U. Jain et al.   MOLECULAR CELL

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

(2020) Siddhant U. Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

(2020) Sima Khazaei et al.   Cancer Discovery

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

(2020) Carol C.L. Chen et al.   CELL

Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients

(2020) Laura Bryant et al.   Science Advances

Phase separation and histone epigenetics in genome regulation

(2020) Reed E.S. Harrison et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

Old cogs, new tricks: the evolution of gene expression in a chromatin context

(2019) Paul B. Talbert et al.   NATURE REVIEWS GENETICS

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

(2019) Brian Krug et al.   CANCER CELL

Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells

(2019) J. Fellenberg et al.   CANCER LETTERS

DAXX in cancer: phenomena, processes, mechanisms and regulation

(2019) Iqbal Mahmud et al.   NUCLEIC ACIDS RESEARCH

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

(2019) Richard L Bennett et al.   Cancer Discovery

Liquid–Liquid Phase Separation in Disease

(2019) Simon Alberti et al.   Annual Review of Genetics

Stalled developmental programs at the root of pediatric brain tumors

(2019) Selin Jessa et al.   NATURE GENETICS

EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells

(2019) Roberta Ragazzini et al.   Nature Communications

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins

(2018) Jie Wang et al.   CELL

Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis

(2018) Leilei Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Frequent epigenetic alterations in polycomb repressive complex 2 in osteosarcoma cell lines

(2018) Helin Feng et al.   Oncotarget

H3–H4 Histone Chaperone Pathways

(2018) Prerna Grover et al.   Annual Review of Genetics

Cancer-driving H3G34V/R/D mutations block H3K36 methylation and H3K36me3–MutSα interaction

(2018) Jun Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase separated microenvironments inside the cell nucleus are linked to disease and regulate epigenetic state, transcription and RNA processing

(2018) Iain A. Sawyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma

(2018) Hsiao P. J. Voon et al.   Nature Communications

An update of molecular pathology of bone tumors. Lessons learned from investigating samples by next generation sequencing

(2018) Daniel Baumhoer et al.   GENES CHROMOSOMES & CANCER

Nuclear condensates of the Polycomb protein chromobox 2 (CBX2) assemble through phase separation

(2018) Roubina Tatavosian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple modes of PRC2 inhibition elicit global chromatin alterations in H3K27M pediatric glioma

(2018) James M. Stafford et al.   Science Advances

Oncohistones: drivers of pediatric cancers

(2017) Faizaan Mohammad et al.   GENES & DEVELOPMENT

The Histone Variant H3.3 in Transcriptional Regulation and Human Disease

(2017) Leilei Shi et al.   JOURNAL OF MOLECULAR BIOLOGY

H3F3 mutation status of giant cell tumors of the bone, chondroblastomas and their mimics: a combined high resolution melting and pyrosequencing approach

(2017) Thibault Kervarrec et al.   MODERN PATHOLOGY

Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control

(2017) Federico Tessadori et al.   NATURE GENETICS

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

Variants of core histones and their roles in cell fate decisions, development and cancer

(2017) Marcus Buschbeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

(2017) Dominik Hoelper et al.   Nature Communications

The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing

(2017) Jinyeong Lim et al.   Scientific Reports

Histone H1 alterations in cancer

(2016) Paola Scaffidi   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Molecular basis for oncohistone H3 recognition by SETD2 methyltransferase

(2016) Shuang Yang et al.   GENES & DEVELOPMENT

Preleukemia: one name, many meanings

(2016) H P Koeffler et al.   LEUKEMIA

Epigenetic modulators, modifiers and mediators in cancer aetiology and progression

(2016) Andrew P. Feinberg et al.   NATURE REVIEWS GENETICS

The molecular hallmarks of epigenetic control

(2016) C. David Allis et al.   NATURE REVIEWS GENETICS

Histone variants on the move: substrates for chromatin dynamics

(2016) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aberrant H3.3 dynamics in NAc promote vulnerability to depressive-like behavior

(2016) Ashley E. Lepack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition

(2016) Siming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas

(2016) D. Fang et al.   SCIENCE

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

(2016) Antonia Piazzesi et al.   Cell Reports

Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma

(2015) Arjen H.G. Cleven et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas

(2015) R. A. Toledo et al.   CLINICAL CANCER RESEARCH

The Mendelian disorders of the epigenetic machinery

(2015) Hans Tomas Bjornsson   GENOME RESEARCH

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Critical Role of Histone Turnover in Neuronal Transcription and Plasticity

(2015) Ian Maze et al.   NEURON

RANK pathway in giant cell tumor of bone: pathogenesis and therapeutic aspects

(2015) Pan-Feng Wu et al.   TUMOR BIOLOGY

ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes

(2015) Hsiao P.J. Voon et al.   Cell Reports

Epigenome Mapping Reveals Distinct Modes of Gene Regulation and Widespread Enhancer Reprogramming by the Oncogenic Fusion Protein EWS-FLI1

(2015) Eleni M. Tomazou et al.   Cell Reports

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36

(2014) Zhongjun Cheng et al.   GENES & DEVELOPMENT

Every amino acid matters: essential contributions of histone variants to mammalian development and disease

(2014) Ian Maze et al.   NATURE REVIEWS GENETICS

Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells

(2013) Laura A. Banaszynski et al.   CELL

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

Identification of a novel, recurrentMBTD1-CXorf67fusion in low-grade endometrial stromal sarcoma

(2013) Barbara Dewaele et al.   INTERNATIONAL JOURNAL OF CANCER

Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone

(2013) Sam Behjati et al.   NATURE GENETICS

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy

(2013) Cigall Kadoch et al.   NATURE GENETICS

From neural development to cognition: unexpected roles for chromatin

(2013) Jehnna L. Ronan et al.   NATURE REVIEWS GENETICS

Epigenetic Reprogramming in Cancer

(2013) M. L. Suva et al.   SCIENCE

Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma

(2013) P. W. Lewis et al.   SCIENCE

The chromatin remodeller ATRX: a repeat offender in human disease

(2013) David Clynes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Histone H3.3 Mutations Drive Pediatric Glioblastoma through Upregulation of MYCN

(2013) Lynn Bjerke et al.   Cancer Discovery

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

(2012) C. Simon et al.   GENES & DEVELOPMENT

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Calcium-Dependent Dephosphorylation of the Histone Chaperone DAXX Regulates H3.3 Loading and Transcription upon Neuronal Activation

(2012) David Michod et al.   NEURON

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

Ollier disease and Maffucci syndrome are caused by somatic mosaic mutations of IDH1 and IDH2

(2011) M Fernanda Amary et al.   NATURE GENETICS

Loss of SMARCB1/INI1 expression in poorly differentiated chordomas

(2010) Bret C. Mobley et al.   ACTA NEUROPATHOLOGICA

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

(2010) D. B. Yap et al.   BLOOD

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study

(2010) David Thomas et al.   LANCET ONCOLOGY

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of platelet-derived growth factor-alpha receptor and c-kit in giant cell tumours of bone

(2009) Irene Sulzbacher et al.   PATHOLOGY

Telomere biology in giant cell tumour of bone

(2008) RG Forsyth et al.   JOURNAL OF PATHOLOGY

Changes in the Distributions and Dynamics of Polycomb Repressive Complexes during Embryonic Stem Cell Differentiation

(2008) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY