Histone variant H3 .3 promotes metastasis in alveolar rhabdomyosarcoma

Defining the Extracellular Matrix of Rhabdomyosarcoma

(2021) Xiaolei Lian et al.   Frontiers in Oncology

Pediatric Rhabdomyosarcoma: Epidemiology and Genetic Susceptibility

(2021) Bailey A. Martin-Giacalone et al.   Journal of Clinical Medicine

Therapeutic targeting of soluble CD146/MCAM with the M2J‐1 monoclonal antibody prevents metastasis development and procoagulant activity in CD146‐positive invasive tumors

(2020) Jimmy Stalin et al.   INTERNATIONAL JOURNAL OF CANCER

Microenvironment remodeled by tumor and stromal cells elevates fibroblast-derived COL1A1 and facilitates ovarian cancer metastasis

(2020) Mingyue Li et al.   EXPERIMENTAL CELL RESEARCH

Prohibitin participates in the HIRA complex to promote cell metastasis in breast cancer cell lines

(2020) Xiaoqing Huang et al.   FEBS Open Bio

Genetics, epigenetics and redox homeostasis in rhabdomyosarcoma: Emerging targets and therapeutics

(2019) Ananya Pal et al.   Redox Biology

Epigenetic regulation of the PTEN-AKT-RAC1 axis by G9a is critical for tumor growth in alveolar rhabdomyosarcoma

(2019) Akshay V Bhat et al.   CANCER RESEARCH

Collagen 1A1 (COL1A1) Is a Reliable Biomarker and Putative Therapeutic Target for Hepatocellular Carcinogenesis and Metastasis

(2019) Hon-Ping Ma et al.   Cancers

Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization

(2019) Ana P. Gomes et al.   CANCER CELL

Current and Future Treatment Strategies for Rhabdomyosarcoma

(2019) Celine Chen et al.   Frontiers in Oncology

Fifty years of rhabdomyosarcoma studies on both sides of the pond and lessons learned

(2018) Carola A.S. Arndt et al.   CANCER TREATMENT REVIEWS

Tumor suppressor functions of DAXX through histone H3.3/H3K9me3 pathway in pancreatic NETs

(2018) Hiroki Ueda et al.   ENDOCRINE-RELATED CANCER

PAX3-FOXO1: Zooming in on an “undruggable” target

(2018) Marco Wachtel et al.   SEMINARS IN CANCER BIOLOGY

Global H3.3 dynamic deposition defines its bimodal role in cell fate transition

(2018) Hai-Tong Fang et al.   Nature Communications

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

(2018) Dominique Ray-Gallet et al.   Nature Communications

UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis-regulatory elements of genes in mouse ES cells

(2018) Chaoyang Xiong et al.   BMC BIOLOGY

Therapeutic Approaches Targeting PAX3-FOXO1 and Its Regulatory and Transcriptional Pathways in Rhabdomyosarcoma

(2018) Thanh Hung Nguyen et al.   MOLECULES

Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization

(2018) Jinyoung Park et al.   NUCLEIC ACIDS RESEARCH

RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells

(2017) Honglian Zhang et al.   MOLECULAR CELL

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

(2017) Dominik Hoelper et al.   Nature Communications

A novel anti-CD146 antibody specifically targets cancer cells by internalizing the molecule

(2017) Marie Nollet et al.   Oncotarget

Prognostic value of CD146 in solid tumor: A Systematic Review and Meta-analysis

(2017) Ping Zeng et al.   Scientific Reports

Histone variants on the move: substrates for chromatin dynamics

(2016) Paul B. Talbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rhabdomyosarcoma

(2016) Roshni Dasgupta et al.   Seminars in Pediatric Surgery

Histone variant H3F3A promotes lung cancer cell migration through intronic regulation

(2016) Seong-Min Park et al.   Nature Communications

Enhancer regions show high histone H3.3 turnover that changes during differentiation

(2016) Aimee M Deaton et al.   eLife

A brief review of nucleosome structure

(2015) Amber R. Cutter et al.   FEBS LETTERS

Histone H3.3 maintains genome integrity during mammalian development

(2015) Chuan-Wei Jang et al.   GENES & DEVELOPMENT

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma

(2015) Masafumi Seki et al.   Nature Communications

Functional Role of G9a Histone Methyltransferase in Cancer

(2015) Francesco Casciello et al.   Frontiers in Immunology

Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors

(2014) J. F. Shern et al.   Cancer Discovery

Classification of Rhabdomyosarcoma and Its Molecular Basis

(2013) David M. Parham et al.   ADVANCES IN ANATOMIC PATHOLOGY

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

H3.3 actively marks enhancers and primes gene transcription via opening higher-ordered chromatin

(2013) P. Chen et al.   GENES & DEVELOPMENT

Voltage-gated sodium channels and metastatic disease

(2012) William J. Brackenbury   Channels

DAXX envelops a histone H3.3–H4 dimer for H3.3-specific recognition

(2012) Simon J. Elsässer et al.   NATURE

Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft-tissue Sarcoma committee experience and rationale for current COG studies

(2012) Suman Malempati et al.   PEDIATRIC BLOOD & CANCER

MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells

(2012) Zheng Wu et al.   TUMOR BIOLOGY

A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus

(2012) Emmanuelle Szenker et al.   Cell Reports

Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers

(2012) Rimas J. Orentas et al.   Frontiers in Oncology

Nucleosome Structure(s) and Stability: Variations on a Theme

(2011) Andrew J. Andrews et al.   Annual Review of Biophysics

Rhabdomyosarcoma in Children: A SEER Population Based Study

(2011) Eduardo A. Perez et al.   JOURNAL OF SURGICAL RESEARCH

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

Fusion Gene–Negative Alveolar Rhabdomyosarcoma Is Clinically and Molecularly Indistinguishable From Embryonal Rhabdomyosarcoma

(2010) Daniel Williamson et al.   JOURNAL OF CLINICAL ONCOLOGY

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myogenic transcriptional activation of MyoD mediated by replication-independent histone deposition

(2010) J.-H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone H1 binding is inhibited by histone variant H3.3

(2009) Ulrich Braunschweig et al.   EMBO JOURNAL

H3.3/H2A.Z double variant–containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions

(2009) Chunyuan Jin et al.   NATURE GENETICS