Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation

GM-CSF drives dysregulated hematopoietic stem cell activity and pathogenic extramedullary myelopoiesis in experimental spondyloarthritis

(2020) Daniel Regan-Komito et al.   Nature Communications

HIRA, a DiGeorge Syndrome Candidate Gene, Confers Proper Chromatin Accessibility on HSCs and Supports All Stages of Hematopoiesis

(2020) Chao Chen et al.   Cell Reports

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics

(2020) Victoria Mutua et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

(2020) Steven Henikoff et al.   eLife

Interferon-Independent Upregulation of Interferon-Stimulated Genes during Human Cytomegalovirus Infection is Dependent on IRF3 Expression

(2019) Caroline Ashley et al.   Viruses-Basel

Neutrophils and NETS in modulating acute and chronic inflammation

(2019) Fernanda Vargas e Silva Castanheira et al.   BLOOD

Mechanisms of Inflammation in Neutrophil-Mediated Skin Diseases

(2019) Angelo V. Marzano et al.   Frontiers in Immunology

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures

(2019) Zulekha A. Qadeer et al.   CANCER CELL

Interferon-Independent Innate Responses to Cytomegalovirus

(2019) Caroline L. Ashley et al.   Frontiers in Immunology

Thrombopoietin protects hematopoietic stem cells from retrotransposon-mediated damage by promoting an antiviral response

(2018) Daniela Barbieri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancer and Transcription Factor Dynamics during Myeloid Differentiation Reveal an Early Differentiation Block in Cebpa null Progenitors

(2018) Sachin Pundhir et al.   Cell Reports

Functional activity of the H3.3 histone chaperone complex HIRA requires trimerization of the HIRA subunit

(2018) Dominique Ray-Gallet et al.   Nature Communications

The epigenetic basis of hematopoietic stem cell aging

(2017) Ashley Kramer et al.   SEMINARS IN HEMATOLOGY

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX

(2017) Dominik Hoelper et al.   Nature Communications

Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo

(2017) Christoph Hirche et al.   Cell Reports

ATRX and DAXX: Mechanisms and Mutations

(2017) Michael A. Dyer et al.   Cold Spring Harbor Perspectives in Medicine

Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of nonhematopoietic genes

(2016) S. Koide et al.   BLOOD

How retrotransposons shape genome regulation

(2016) Paolo Mita et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epigenetics of hematopoiesis and hematological malignancies

(2016) Deqing Hu et al.   GENES & DEVELOPMENT

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

PU.1 cooperates with IRF4 and IRF8 to suppress pre-B-cell leukemia

(2016) S H M Pang et al.   LEUKEMIA

Potential Pitfalls of the Mx1-Cre System: Implications for Experimental Modeling of Normal and Malignant Hematopoiesis

(2016) Talia Velasco-Hernandez et al.   Stem Cell Reports

Age-Associated Decrease of the Histone Methyltransferase SUV39H1 in HSC Perturbs Heterochromatin and B Lymphoid Differentiation

(2016) Dounia Djeghloul et al.   Stem Cell Reports

Human endogenous retroviruses and cancer

(2016) Gonzalez-Cao María et al.   Cancer Biology & Medicine

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

(2015) Patrick L. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

(2014) Ha-Reum Lee et al.   CELLULAR IMMUNOLOGY

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

(2014) Taranjit Singh Rai et al.   GENES & DEVELOPMENT

The role of mutations in epigenetic regulators in myeloid malignancies

(2014) Brittany A. Woods et al.   IMMUNOLOGICAL REVIEWS

Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

(2014) Ronan F. Downey et al.   INTERNATIONAL JOURNAL OF CANCER

Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

(2014) Eric M. Pietras et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Chromatin state dynamics during blood formation

(2014) D. Lara-Astiaso et al.   SCIENCE

Endogenous retroviruses function as species-specific enhancer elements in the placenta

(2013) Edward B Chuong et al.   NATURE GENETICS

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA

(2013) Benjamin Herquel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aggressive acute myeloid leukemia in PU.1/p53 double-mutant mice

(2013) P Basova et al.   ONCOGENE

diffReps: Detecting Differential Chromatin Modification Sites from ChIP-seq Data with Biological Replicates

(2013) Li Shen et al.   PLoS One

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

TERRA Promotes Telomere Shortening through Exonuclease 1–Mediated Resection of Chromosome Ends

(2012) Verena Pfeiffer et al.   PLoS Genetics

Peroxisomes Are Signaling Platforms for Antiviral Innate Immunity

(2010) Evelyn Dixit et al.   CELL

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Pyoderma gangraenosum

(2010) Uwe Wollina et al.   CURRENT OPINION IN RHEUMATOLOGY

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

Surprising new roles for PU.1 in the adaptive immune response

(2010) Sebastian Carotta et al.   IMMUNOLOGICAL REVIEWS

Transposable elements have rewired the core regulatory network of human embryonic stem cells

(2010) Galih Kunarso et al.   NATURE GENETICS

The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase

(2010) Sophie Redon et al.   NUCLEIC ACIDS RESEARCH

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Functional Screen to Identify Novel Effectors of Hematopoietic Stem Cell Activity

(2009) Eric Deneault et al.   CELL

Telomeric RNAs Mark Sex Chromosomes in Stem Cells

(2009) L.-F. Zhang et al.   GENETICS

Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon–dependent exhaustion

(2009) Taku Sato et al.   NATURE MEDICINE