Structural basis for membrane-proximal proteolysis of substrates by ADAM10

The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors

(2022) Chek Ziu Koo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81

(2021) Katherine J. Susa et al.   SCIENCE

Biophysics of Notch Signaling

(2021) David Sprinzak et al.   Annual Review of Biophysics

Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential

(2021) Neale Harrison et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

(2021) Ruben Sanchez-Garcia et al.   Communications Biology

Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site

(2021) Colin H. Lipper et al.   STRUCTURE

The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex

(2020) Chek Ziu Koo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

(2020) Sampath K. Loganathan et al.   SCIENCE

Structural insights into tetraspanin CD9 function

(2020) Rie Umeda et al.   Nature Communications

A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking

(2020) Katherine J Susa et al.   eLife

Open conformation of tetraspanins shapes interaction partner networks on cell membranes

(2020) Yihu Yang et al.   EMBO JOURNAL

Tspan15 plays a crucial role in metastasis in oral squamous cell carcinoma

(2019) Kazuya Hiroshima et al.   EXPERIMENTAL CELL RESEARCH

In vivo regulation of the A disintegrin and metalloproteinase 10 (ADAM10) by the tetraspanin 15

(2018) Lisa Seipold et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Proteolytic ectodomain shedding of membrane proteins in mammals—hardware, concepts, and recent developments

(2018) Stefan F Lichtenthaler et al.   EMBO JOURNAL

TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling

(2018) Baozhu Zhang et al.   Nature Communications

A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity

(2018) Jimit Shah et al.   Cell Reports

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket

(2016) Brandon Zimmerman et al.   CELL

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

(2016) Peer-Hendrik Kuhn et al.   eLife

TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization

(2015) Stéphanie Jouannet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions

(2015) Peter J. Noy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Collaboration gets the most out of software

(2013) Andrew Morin et al.   eLife

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10

(2012) Johannes Prox et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL

(2011) M L Sulis et al.   LEUKEMIA

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

(2011) Guiomar Solanas et al.   NATURE CELL BIOLOGY

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

ADAM-10-Mediated N-Cadherin Cleavage Is Protein Kinase C-  Dependent and Promotes Glioblastoma Cell Migration

(2009) Z. A. Kohutek et al.   JOURNAL OF NEUROSCIENCE

TACE-Mediated Ectodomain Shedding of the Type I TGF-β Receptor Downregulates TGF-β Signaling

(2009) Cheng Liu et al.   MOLECULAR CELL

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer

(2008) Jessica Pruessmeyer et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY