SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1‐dependent reduction of esterified cholesterol

Programmed cell death‐1 blockade therapy in melanoma: Resistance mechanisms and combination strategies

(2023) Yixin Zou et al.   EXPERIMENTAL DERMATOLOGY

Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

(2023) Carina B. Nava Lauson et al.   Cell Metabolism

Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody

(2022) Yuki Katoh et al.   Journal for ImmunoTherapy of Cancer

Drug-Loaded Nanocarriers Composed of Cholesteryl Oleate Crystal Cores and Multiple-Nanosheet Shells of γ-Cyclodextrin Inclusion Complex Crystals

(2022) Arisa Ishimoto et al.   LANGMUIR

Lipids for CD8+ TILs: Beneficial or harmful?

(2022) Duojiao Wu et al.   Frontiers in Immunology

Combination bezafibrate and nivolumab treatment of patients with advanced non–small cell lung cancer

(2022) Kentaro Tanaka et al.   Science Translational Medicine

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Knockdown of sterol O-acyltransferase 1 (SOAT1) suppresses SCD1-mediated lipogenesis and cancer procession in prostate cancer

(2021) Yuan Liu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Current issues and perspectives in PD-1 blockade cancer immunotherapy

(2020) Kenji Chamoto et al.   International Journal of Clinical Oncology

Structural basis for catalysis and substrate specificity of human ACAT1

(2020) Hongwu Qian et al.   NATURE

Structure of nevanimibe-bound tetrameric human ACAT1

(2020) Tao Long et al.   NATURE

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

(2020) Daiki Kato et al.   eLife

Targeting Metabolism to Improve the Tumor Microenvironment for Cancer Immunotherapy

(2020) Jackie E. Bader et al.   MOLECULAR CELL

Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma

(2019) Ying Jiang et al.   NATURE

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion

(2019) Robert D. Leone et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Principles of adoptive T cell therapy in cancer

(2018) Özcan Met et al.   Seminars in Immunopathology

PPAR-induced fatty acid oxidation in T cells increases the number of tumor-reactive CD8+ T cells and facilitates anti-PD-1 therapy

(2018) Partha S. Chowdhury et al.   Cancer Immunology Research

IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

(2017) Mark Ayers et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel capsule-like structure of micro-sized particles formed by phytosterol ester and γ-cyclodextrin in water

(2016) Hiroshi Sasako et al.   FOOD CHEMISTRY

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer

(2016) J Li et al.   ONCOGENE

X-ray structure of a mammalian stearoyl-CoA desaturase

(2015) Yonghong Bai et al.   NATURE

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Immune targeting of fibroblast activation protein triggers recognition of multipotent bone marrow stromal cells and cachexia

(2013) Eric Tran et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Suppression and Resistance Mediated by Constitutive Activation of Wnt/ -Catenin Signaling in Human Melanoma Cells

(2012) T. Yaguchi et al.   JOURNAL OF IMMUNOLOGY

Stearoyl-CoA desaturase: rogue or innocent bystander?

(2012) Leanne Hodson et al.   PROGRESS IN LIPID RESEARCH

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

(2010) Kiyotaka Nakano et al.   ANTI-CANCER DRUGS

Gene therapy using genetically modified lymphocytes targeting VEGFR-2 inhibits the growth of vascularized syngenic tumors in mice

(2010) Dhanalakshmi Chinnasamy et al.   JOURNAL OF CLINICAL INVESTIGATION

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells

(2008) Kiyotaka Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS