TPE conjugated islet amyloid polypeptide probe for detection of peptide oligomers

An AIE-Active NIR Fluorescent Probe with Good Water Solubility for the Detection of Aβ1–42 Aggregates in Alzheimer’s Disease

(2023) Yan-Ming Ji et al.   MOLECULES

Bioinspired enzymatic compartments constructed by spatiotemporally confined in situ self-assembly of catalytic peptide

(2022) Yaling Wang et al.   Communications Chemistry

Contribution of the 12–17 hydrophobic region of islet amyloid polypeptide in self-assembly and cytotoxicity

(2022) Mathilde Fortier et al.   Frontiers in Molecular Biosciences

Hydrophilic AIE-Active Tetraarylethenes for Fluorescence Sensing and Super-Resolution Imaging of Amyloid Fibrils from Hen Egg White Lysozyme

(2021) Cheng Fan et al.   ACS Applied Materials & Interfaces

Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates

(2021) Diana C. Rodriguez Camargo et al.   Frontiers in Molecular Biosciences

Analysis of Baboon IAPP Provides Insight into Amyloidogenicity and Cytotoxicity of Human IAPP

(2020) Zachary Ridgway et al.   BIOPHYSICAL JOURNAL

Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

(2020) Christine Röder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Role of Glycation on the Aggregation Properties of IAPP

(2020) Giulia Milordini et al.   Frontiers in Molecular Biosciences

Role of lysine residue of islet amyloid polypeptide in fibril formation, membrane binding, and inhibitor binding

(2020) Meng-Hsin Wu et al.   BIOCHIMIE

Protein glycation by glyoxal promotes amyloid formation by islet amyloid polypeptide

(2019) Yi-Hsuan Hsu et al.   BIOPHYSICAL JOURNAL

IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function

(2019) Chiara Montemurro et al.   Nature Communications

A single mutation on the human amyloid polypeptide modulates fibril growth and affects the mechanism of amyloid-induced membrane damage

(2018) Anais R.F. Hoffmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Kinetic and Conformational Insights into Islet Amyloid Polypeptide Self-Assembly Using a Biarsenical Fluorogenic Probe

(2018) Noé Quittot et al.   BIOCONJUGATE CHEMISTRY

Probing amylin fibrillation at an early stage via a tetracysteine-recognising fluorophore

(2017) Shih-Ting Wang et al.   TALANTA

Development of 99mTc-Labeled Pyridyl Benzofuran Derivatives To Detect Pancreatic Amylin in Islet Amyloid Model Mice

(2016) Masashi Yoshimura et al.   BIOCONJUGATE CHEMISTRY

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

Detection and Monitoring of Amyloid Fibrillation Using a Fluorescence “Switch-On” Probe

(2015) Nibedita Pradhan et al.   ACS Applied Materials & Interfaces

Aggregation-Induced Emission: The Whole Is More Brilliant than the Parts

(2014) Ju Mei et al.   ADVANCED MATERIALS

Feasibility of Amylin Imaging in Pancreatic Islets with β-Amyloid Imaging Probes

(2014) Masashi Yoshimura et al.   Scientific Reports

Cyclic N-Terminal Loop of Amylin Forms Non Amyloid Fibers

(2013) Stephanie M. Cope et al.   BIOPHYSICAL JOURNAL

Mechanisms of islet amyloidosis toxicity in type 2 diabetes

(2013) Andisheh Abedini et al.   FEBS LETTERS

Role of Aromatic Interactions in Amyloid Formation by Islet Amyloid Polypeptide

(2012) Ling-Hsien Tu et al.   BIOCHEMISTRY

Monitoring and Inhibition of Insulin Fibrillation by a Small Organic Fluorogen with Aggregation-Induced Emission Characteristics

(2011) Yuning Hong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

The Ability of Rodent Islet Amyloid Polypeptide To Inhibit Amyloid Formation by Human Islet Amyloid Polypeptide Has Important Implications for the Mechanism of Amyloid Formation and the Design of Inhibitors

(2009) Ping Cao et al.   BIOCHEMISTRY

Aggregation-induced emission: phenomenon, mechanism and applications

(2009) Yuning Hong et al.   CHEMICAL COMMUNICATIONS

A critical assessment of the role of helical intermediates in amyloid formation by natively unfolded proteins and polypeptides

(2009) A. Abedini et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY