Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor
出版年份 2023 全文链接
标题
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor
作者
关键词
-
出版物
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 93, Issue -, Pages 117460
出版商
Elsevier BV
发表日期
2023-08-26
DOI
10.1016/j.bmc.2023.117460
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- (2023) Tanya Collin-Histed et al. Orphanet Journal of Rare Diseases
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- (2022) Jia Shi et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Adipose deficiency and aberrant autophagy in a Drosophila model of MPS VII is corrected by pharmacological stimulators of mTOR
- (2022) Indrani Basu et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Perinatal lethal Gaucher disease: A case report and review of literature
- (2022) Rie Chida et al. BRAIN & DEVELOPMENT
- Heparanase: A Novel Therapeutic Target for the Treatment of Atherosclerosis
- (2022) Tien K. Nguyen et al. Cells
- Lead identification of novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent heparanase-1 inhibitor
- (2022) Yudai Imai et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Diagnosis and Emerging Treatment Strategies for Mucopolysaccharidosis VII (Sly Syndrome)
- (2022) Fabiano de Oliveira Poswar et al. Therapeutics and Clinical Risk Management
- Entropy-driven binding of gut bacterial β-glucuronidase inhibitors ameliorates irinotecan-induced toxicity
- (2021) Hsien-Ya Lin et al. Communications Biology
- Fragment molecular orbital calculations for biomolecules
- (2021) Kaori Fukuzawa et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Heparanase and the hallmarks of cancer
- (2020) Krishnath M. Jayatilleke et al. Journal of Translational Medicine
- Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish
- (2019) Marta Artola et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Vestronidase Alfa: A Review in Mucopolysaccharidosis VII
- (2019) Emma H. McCafferty et al. BIODRUGS
- Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy
- (2018) Monica Galli et al. HAEMATOLOGICA
- Phase I study of the heparanase inhibitor Roneparstat: an innovative approach for multiple myeloma therapy
- (2018) Monica Galli et al. HAEMATOLOGICA
- Inhibition of heparanase protects against chronic kidney dysfunction following ischemia/reperfusion injury
- (2018) Valentina Masola et al. Oncotarget
- Heparanase Is Essential for the Development of Acute Experimental Glomerulonephritis
- (2016) Marjolein Garsen et al. AMERICAN JOURNAL OF PATHOLOGY
- Structural characterization of human heparanase reveals insights into substrate recognition
- (2015) Liang Wu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural characterization of human heparanase reveals insights into substrate recognition
- (2015) Liang Wu et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Synthesis and evaluation of 3-deoxy and 3-deoxy-3-fluoro derivatives of gluco- and manno-configured tetrahydropyridoimidazole glycosidase inhibitors
- (2013) Cécile Ouairy et al. CARBOHYDRATE RESEARCH
- GAMESS As a Free Quantum-Mechanical Platform for Drug Research
- (2013) Yuri Alexeev et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Lysosomal β-glucuronidase regulates Lyme and rheumatoid arthritis severity
- (2013) Kenneth K.C. Bramwell et al. JOURNAL OF CLINICAL INVESTIGATION
- The role of heparanase and the endothelial glycocalyx in the development of proteinuria
- (2013) Marjolein Garsen et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Synthesis of a Pseudo-Disaccharide Library and Its Application to the Characterisation of the Heparanase Catalytic Site
- (2013) Victoria Vinader et al. PLoS One
- Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues
- (2013) Edward Hammond et al. FEBS Open Bio
- Exploring chemistry with the fragment molecular orbital method
- (2012) Dmitri G. Fedorov et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Structure–activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors
- (2011) Tiehai Li et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Heparanase Is Essential for the Development of Diabetic Nephropathy in Mice
- (2011) N. Gil et al. DIABETES
- Development of Specific “Drug-Like Property” Rules for Carboxylate-Containing Oral Drug Candidates
- (2010) Alexander Böcker et al. ChemMedChem
- Efficient parallel algorithm of second-order Møller-Plesset perturbation theory with resolution-of-identity approximation (RI-MP2)
- (2009) Michio Katouda et al. INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY
- Heparanase inhibitor PI-88 as adjuvant therapy for hepatocellular carcinoma after curative resection: A randomized phase II trial for safety and optimal dosage
- (2009) Chun-Jen Liu et al. JOURNAL OF HEPATOLOGY
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- (2008) Ghada Abboud-Jarrous et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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