Design, Development and Bio-evaluation of a novel radio-ligand 99mTc-THQ-DTPA as a sigma 2 receptor specific breast tumor imaging agent

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Sigma receptors and neurological disorders

(2021) Agnieszka Piechal et al.   Pharmacological Reports

Structures of the σ2 receptor enable docking for bioactive ligand discovery

(2021) Assaf Alon et al.   NATURE

Synthesis and pharmacological evaluation of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as sigma-2 receptor ligands

(2018) Yu-Tong Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, physico-chemical and pre-clinical evaluation of a homo-bivalent 99mTc-(BTZ)2DTPA radioligand for targeting dimeric 5-HT1A/5-HT7 receptors

(2018) Preeti Jha et al.   NEW JOURNAL OF CHEMISTRY

Technetium-99m radiochemistry for pharmaceutical applications

(2017) Dionysia Papagiannopoulou   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease

(2017) Bitna Yi et al.   JOURNAL OF NEUROCHEMISTRY

Identification of the gene that codes for the σ2receptor

(2017) Assaf Alon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

99mTc-Cyclopentadienyl Tricarbonyl Chelate-Labeled Compounds as Selective Sigma-2 Receptor Ligands for Tumor Imaging

(2016) Dan Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

The sigma-2 receptor as a therapeutic target for drug delivery in triple negative breast cancer

(2015) Mehran Makvandi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of pulmonary sigma receptors by radioligand binding

(2015) John R. Lever et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

RNA interference against TMEM97 inhibits cell proliferation, migration, and invasion in glioma cells

(2015) Guanzhong Qiu et al.   TUMOR BIOLOGY

The σ2 Receptor: A Novel Protein for the Imaging and Treatment of Cancer

(2013) Robert H. Mach et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessment of Cellular Proliferation in Tumors by PET Using 18F-ISO-1

(2013) F. Dehdashti et al.   JOURNAL OF NUCLEAR MEDICINE

Sigma-2 Receptor Ligands and Their Perspectives in Cancer Diagnosis and Therapy

(2013) Yun-Sheng Huang et al.   MEDICINAL RESEARCH REVIEWS

Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands

(2013) Mark E. Ashford et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Quantitative Receptor-Based Imaging of Tumor Proliferation with the Sigma-2 Ligand [18F]ISO-1

(2013) Kooresh I. Shoghi et al.   PLoS One

Synthesis and biological evaluation of a novel 99mTc cyclopentadienyl tricarbonyl complex ([(Cp-R)99mTc(CO)3]) for sigma-2 receptor tumor imaging

(2012) Xin Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Therapeutic Potential of Sigma (σ) Receptors for the Treatment of Central Nervous System Diseases: Evaluation of the Evidence

(2012) Samuel D. Banister et al.   CURRENT PHARMACEUTICAL DESIGN

Radiosynthesis and biological evaluation of a promising σ2-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer

(2010) Zhude Tu et al.   APPLIED RADIATION AND ISOTOPES

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY