Discovery of a new dihydroeugenol-chalcone hybrid with cytotoxic and anti-migratory potential: a dual-action hit for cancer therapeutics

Could inhibition of metalloproteinases be used to block the process of metastasis?

(2022) Jesús Alba et al.   CELL BIOCHEMISTRY AND FUNCTION

The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

(2022) Yuhe Huang et al.   Journal of Hematology & Oncology

Steps in metastasis: an updated review

(2021) Jamal Majidpoor et al.   MEDICAL ONCOLOGY

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

(2021) Bahare Salehi et al.   Frontiers in Pharmacology

Synthesis and structural characterization of new benzylidene glycosides, cytotoxicity against cancer cell lines and molecular modeling studies

(2021) Vinícius Augusto Campos Péret et al.   JOURNAL OF MOLECULAR STRUCTURE

Novel therapeutic targets for cancer metastasis

(2020) Konstantin Stoletov et al.   Expert Review of Anticancer Therapy

Upgraded AMBER Force Field for Zinc-Binding Residues and Ligands for Predicting Structural Properties and Binding Affinities in Zinc-Proteins

(2020) Marina Macchiagodena et al.   ACS Omega

Bladder Cancer

(2020) Andrew T. Lenis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment

(2020) Katherine C. Kurnit et al.   OBSTETRICS AND GYNECOLOGY

Ovarian Cancer: An Integrated Review

(2019) Christine Stewart et al.   Seminars in Oncology Nursing

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Upgrading and Validation of the AMBER Force Field for Histidine and Cysteine Zinc(II)-Binding Residues in Sites with Four Protein Ligands

(2019) Marina Macchiagodena et al.   Journal of Chemical Information and Modeling

Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway

(2019) Hongtian Zhu et al.   Frontiers in Pharmacology

The effects of zinc treatment on matrix metalloproteinases: A systematic review

(2019) Rahmat Nosrati et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

The recent progress of isoxazole in medicinal chemistry

(2018) Jie Zhu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations

(2018) Maximilian Scheurer et al.   BIOPHYSICAL JOURNAL

In vitro and in vivo trypanocidal activities of 8-methoxy-3-(4-nitrobenzoyl)-6-propyl-2H -cromen-2-one, a new synthetic coumarin of low cytotoxicity against mammalian cells

(2018) Guilherme Andrade Brancaglion et al.   Chemical Biology & Drug Design

Synthesis and biological evaluation of 4-amino-5-cinnamoylthiazoles as chalcone-like anticancer agents

(2018) Adileh Ayati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies

(2018) Elisa Nuti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bridging Molecular Docking to Molecular Dynamics in Exploring Ligand-Protein Recognition Process: An Overview

(2018) Veronica Salmaso et al.   Frontiers in Pharmacology

Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles

(2017) Pinki Yadav et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cell Proliferation and Cytotoxicity Assays

(2016) Aysun Adan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

QSAR, in silico docking and in vitro evaluation of chalcone derivatives as potential inhibitors for H1N1 virus neuraminidase

(2016) Marzieh Yaeghoobi et al.   MEDICINAL CHEMISTRY RESEARCH

An efficient synthesis of 1,3-dimethyl-5-(2-phenyl-4H-chromen-4-ylidene) pyrimidine-2,4,6(1H,3H,5H)-triones and investigation of their interactions with β-lactoglobiulin

(2016) Nayim Sepay et al.   RSC Advances

Anti-cancer chalcones: Structural and molecular target perspectives

(2015) Debarshi Kar Mahapatra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular Docking and Structure-Based Drug Design Strategies

(2015) Leonardo Ferreira et al.   MOLECULES

Inhibition of bladder cancer cell proliferation by allyl isothiocyanate (mustard essential oil)

(2015) André Luiz Ventura Sávio et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Rational approaches, design strategies, structure activity relationship and mechanistic insights for anticancer hybrids

(2014) Kunal Nepali et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Pd(ii)-catalyzed asymmetric approach toward chiral [3.3.1]-bicyclic ketals using 2-hydroxyphenylboronic acid as a pro-bis(nucleophile)

(2013) Feijun Wang et al.   CHEMICAL COMMUNICATIONS

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Antiproliferative and Molecular Mechanism of Eugenol-Induced Apoptosis in Cancer Cells

(2012) Saravana Kumar Jaganathan et al.   MOLECULES

Avogadro: an advanced semantic chemical editor, visualization, and analysis platform

(2012) Marcus D Hanwell et al.   Journal of Cheminformatics

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

(2010) Yves Pommier et al.   CHEMISTRY & BIOLOGY

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase

(2009) Kirk E. Hevener et al.   Journal of Chemical Information and Modeling