Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway

An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent

(2019) Wang Yan et al.   INVESTIGATIONAL NEW DRUGS

How Does Chirality Determine the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers Based on Molecular Dynamics

(2019) Yang Zhang et al.   ACS Chemical Neuroscience

An Improved Method for the Synthesis of Butein Using SOCl2/EtOH as Catalyst and Deciphering Its Inhibition Mechanism on Xanthine Oxidase

(2019) Yu-Xue Hou et al.   MOLECULES

Discovery of a novel chalcone derivative inhibiting CFTR chloride channel via AMPK activation and its anti-diarrheal application

(2019) Chamnan Yibcharoenporn et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A novel chalcone derivative exerts anti-inflammatory and anti-oxidant effects after acute lung injury

(2019) Yuting Lin et al.   Aging-US

Synthesis and biological evaluation of novel synthetic chalcone derivatives as anti-tumor agents targeting Cat L and Cat K

(2018) Yali Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Target ROS to induce apoptosis and cell cycle arrest by 5,7-dimethoxy-1,4-naphthoquinone derivative

(2018) Kun Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms

(2018) Elham Karimi-Sales et al.   PHARMACOLOGICAL RESEARCH

Toxicity of Cancer Therapies in Older Patients

(2018) Olivia Le Saux et al.   Current Oncology Reports

Research progress on common adverse events caused by targeted therapy for colorectal cancer (Review)

(2018) Bo Zhang et al.   Oncology Letters

Treatment of Elderly Patients with Colorectal Cancer

(2018) Yoshiro Itatani et al.   Biomed Research International

Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway

(2018) AJAY BOMMAREDDY et al.   ANTICANCER RESEARCH

Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review

(2018) Changmin Kim et al.   Nutrients

A new chalcone derivative, 3-phenyl-1-(2,4,6-tris(methoxymethoxy)phenyl)prop-2-yn-1-one), inhibits phorbol ester-induced metastatic activity of colorectal cancer cells through upregulation of heme oxygenase-1

(2018) Hao Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies

(2018) Yasuyoshi Miyata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synthesis of new chalcone-based homoserine lactones and their antiproliferative activity evaluation

(2018) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel pyrazolic chalcone derivatives as novel hepatocellular carcinoma therapeutics

(2017) Mohammed M.A. Hawash et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and cytotoxic activity of certain novel chalcone analogous compounds

(2017) S. El-Meligie et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity

(2017) Demet Coskun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chalcone Derivatives: Promising Starting Points for Drug Design

(2017) Marcelo Gomes et al.   MOLECULES

A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

(2017) Saiyang Zhang et al.   Scientific Reports

A novel quinazolinone chalcone derivative induces mitochondrial dependent apoptosis and inhibits PI3K/Akt/mTOR signaling pathway in human colon cancer HCT-116 cells

(2016) Zahoor Ahmad Wani et al.   FOOD AND CHEMICAL TOXICOLOGY

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo

(2016) Jun Yan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evaluation of Novel Chalcone Oximes as Inhibitors of Tyrosinase and Melanin Formation in B16 Cells

(2015) Sini K. Radhakrishnan et al.   ARCHIV DER PHARMAZIE

Synthesis of apoptotic chalcone analogues in HepG2 human hepatocellular carcinoma cells

(2015) Cheon-Soo Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent

(2015) Baoxin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent developments in biological activities of chalcones: A mini review

(2014) Parvesh Singh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel Millepachine Derivatives As a New Class of Tubulin Polymerization Inhibitors

(2014) Zhuang Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Licochalcone A Suppresses Migration and Invasion of Human Hepatocellular Carcinoma Cells through Downregulation of MKK4/JNK via NF-κB Mediated Urokinase Plasminogen Activator Expression

(2014) Jen-Pi Tsai et al.   PLoS One

Sulfenome mining in Arabidopsis thaliana

(2014) C. Waszczak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction

(2013) X. Wang et al.   GENES & DEVELOPMENT

Exploring Pharmacological Significance of Chalcone Scaffold: A Review

(2012) N. K. Sahu et al.   CURRENT MEDICINAL CHEMISTRY

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

(2012) Wenqing Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation

(2011) Szu-Ying Chen et al.   Autophagy

Mitochondrial calcium regulates rat liver regeneration through the modulation of apoptosis

(2011) Mateus T. Guerra et al.   HEPATOLOGY

Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs

(2009) Subhash Padhye et al.   Journal of Hematology & Oncology

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

(2009) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents

(2008) M. Vijaya Bhaskar Reddy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Syntheses and potential anti-prostate cancer activities of ionone-based chalcones

(2008) Jinming Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Studies of structure–activity relationship on plant polyphenol-induced suppression of human liver cancer cells

(2008) Jacky Loa et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

SOCl2/EtOH: Catalytic system for synthesis of chalcones

(2007) Ognyan Petrov et al.   CATALYSIS COMMUNICATIONS