PAD2: A potential target for tumor therapy

Netrin-1 Promotes the Immunosuppressive Activity of MDSCs in Colorectal Cancer

(2023) Xueli Xia et al.   Cancer Immunology Research

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

(2022) Daniel Geh et al.   Nature Reviews Gastroenterology & Hepatology

PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy

(2022) Ruhul H Choudhury et al.   Journal for ImmunoTherapy of Cancer

Long noncoding RNA FAM225A promotes the malignant progression of gastric cancer through the miR-326/PADI2 axis

(2022) Xiang Ma et al.   Cell Death Discovery

Peptidylarginine deiminase 2 promotes T helper 17-like T cell activation and activated T cell-autonomous death (ACAD) through an endoplasmic reticulum stress and autophagy coupling mechanism

(2022) Yi-Fang Yang et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Histone post-translational modifications — cause and consequence of genome function

(2022) Gonzalo Millán-Zambrano et al.   NATURE REVIEWS GENETICS

Improving Cancer Immunotherapy: Exploring and Targeting Metabolism in Hypoxia Microenvironment

(2022) Jinfen Wei et al.   Frontiers in Immunology

Hypoxia as a Modulator of Inflammation and Immune Response in Cancer

(2022) Rosa A. Castillo-Rodríguez et al.   Cancers

Microbial pathways to subvert host immunity generate citrullinated neoantigens targeted in rheumatoid arthritis

(2022) Eduardo Gómez-Bañuelos et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The virtues and vices of protein citrullination

(2022) Maria A. Christophorou   Royal Society Open Science

Morphologic Analysis of M2 Macrophage in Glioblastoma: Involvement of Macrophage Extracellular Traps (METs)

(2022) Ayano Michiba et al.   ACTA HISTOCHEMICA ET CYTOCHEMICA

Anti-PADI4 antibody suppresses breast cancer by repressing the citrullinated fibronectin in the tumor microenvironment

(2022) Yan Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells

(2022) Yan-ni Sun et al.   Current Medical Science

Metabolites as extracellular vesicle cargo in health, cancer, pleural effusion, and cardiovascular diseases: An emerging field of study to diagnostic and therapeutic purposes

(2022) Yan Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Diverse Neutrophil Functions in Cancer and Promising Neutrophil-Based Cancer Therapies

(2022) Khetam Sounbuli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protein arginine deiminase 2 (PAD2) modulates the polarization of THP-1 macrophages to the anti-inflammatory M2 phenotype

(2022) Aneta Stachowicz et al.   Journal of Inflammation-London

Extracellular Vesicles and Their Roles in the Tumor Immune Microenvironment

(2022) Antonia Reale et al.   Journal of Clinical Medicine

The role of noncoding RNAs in cancer lipid metabolism

(2022) Ye Wang et al.   Frontiers in Oncology

PAD4 and Its Inhibitors in Cancer Progression and Prognosis

(2022) Di Zhu et al.   Pharmaceutics

PADI2‐Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1‐Mediated SOX2 mRNA Stability in Endometrial Cancer

(2021) Teng Xue et al.   Advanced Science

Inhibition of PAD4 enhances radiosensitivity and inhibits aggressive phenotypes of nasopharyngeal carcinoma cells

(2021) Hao Chen et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Neutrophil Extracellular Traps and Macrophage Extracellular Traps Predict Postoperative Recurrence in Resectable Nonfunctional Pancreatic Neuroendocrine Tumors

(2021) Shuai-Shuai Xu et al.   Frontiers in Immunology

Sialic acid conjugate-modified liposomes enable tumor homing of epirubicin via neutrophil/monocyte infiltration for tumor therapy

(2021) Junqiang Ding et al.   Acta Biomaterialia

Post-translational modifications: Regulators of neurodegenerative proteinopathies

(2021) Rohan Gupta et al.   AGEING RESEARCH REVIEWS

PAD4 inhibitor promotes DNA damage and radiosensitivity of nasopharyngeal carcinoma cells

(2021) Hao Chen et al.   ENVIRONMENTAL TOXICOLOGY

Neutrophil extracellular traps in cancer: not only catching microbes

(2021) Livia Ronchetti et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Histone citrullination: a new target for tumors

(2021) Dongwei Zhu et al.   Molecular Cancer

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

(2021) María Casanova-Acebes et al.   NATURE

Targeting resident macrophages in cancer

(2021) Xin Li et al.   NATURE IMMUNOLOGY

miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma

(2021) Shukai Yuan et al.   ONCOGENE

Neutrophil extracellular traps in cancer

(2021) Leonardo Cristinziano et al.   SEMINARS IN CANCER BIOLOGY

MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma

(2021) Hyuk Moon et al.   Cancers

Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway

(2021) Xinran Liu et al.   Biomolecules

Macrophages in tumor: An inflammatory perspective

(2021) Kuntal Kanti Goswami et al.   CLINICAL IMMUNOLOGY

Neutrophils prevent rectal bleeding in ulcerative colitis by peptidyl-arginine deiminase-4-dependent immunothrombosis

(2021) Moritz Leppkes et al.   GUT

Interaction Between Macrophage Extracellular Traps and Colon Cancer Cells Promotes Colon Cancer Invasion and Correlates With Unfavorable Prognosis

(2021) Tianli Chen et al.   Frontiers in Immunology

Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4

(2021) María Teresa Martín Monreal et al.   Frontiers in Immunology

Emerging agents that target signaling pathways to eradicate colorectal cancer stem cells

(2021) Valdenizia R. Silva et al.   Cancer Communications

CXCL1-Triggered PAD4 Cytoplasmic Translocation Enhances Neutrophil Adhesion through Citrullination of PDIA1

(2021) Jiro Aoyama et al.   Journal of Atherosclerosis and Thrombosis

Hypomethylation-linked activation of PLCE1 impedes autophagy and promotes tumorigenesis through MDM2-mediated ubiquitination and destabilization of p53

(2020) Yunzhao Chen et al.   CANCER RESEARCH

Human Anti-tumor Immunity: Insights from Immunotherapy Clinical Trials

(2020) Jackson G. Egen et al.   IMMUNITY

Tumor Immunology and Tumor Evolution: Intertwined Histories

(2020) Jérôme Galon et al.   IMMUNITY

Peptidyl Arginine Deiminase 2 (PADI2)-Mediated Arginine Citrullination Modulates Transcription in Cancer

(2020) Miguel Beato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils as emerging therapeutic targets

(2020) Tamás Németh et al.   NATURE REVIEWS DRUG DISCOVERY

lncRNA SLC7A11-AS1 Promotes Chemoresistance by Blocking SCFβ-TRCP-Mediated Degradation of NRF2 in Pancreatic Cancer

(2020) Qingzhu Yang et al.   Molecular Therapy-Nucleic Acids

Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock

(2020) Zhenyu Wu et al.   INFLAMMATION

The roles of PAD2 ‐ and PAD4 ‐mediated protein citrullination catalysis in cancers

(2020) Yanbin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage

(2020) Hui-Chun Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis

(2020) Yuzi Tian et al.   JCI Insight

The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer

(2020) Lining Wei et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Deimination, Intermediate Filaments and Associated Proteins

(2020) Julie Briot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor-Associated Macrophages in Tumor Immunity

(2020) Yueyun Pan et al.   Frontiers in Immunology

Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2

(2019) Li Zheng et al.   BIOCHEMISTRY

Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome–Dependent IL-1β Maturation and ASC Speck Formation in Macrophages

(2019) Neha Mishra et al.   JOURNAL OF IMMUNOLOGY

Extracellular DNA traps in inflammation, injury and healing

(2019) Christoph Daniel et al.   Nature Reviews Nephrology

Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells

(2019) Fujun Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Photochemical Control of Protein Arginine Deiminase (PAD) Activity

(2018) Santanu Mondal et al.   ACS Chemical Biology

Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells

(2018) Stanley B. DeVore et al.   MOLECULAR AND CELLULAR BIOLOGY

Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury

(2018) Koshu Okubo et al.   NATURE MEDICINE

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

(2018) Yuzhang Du et al.   NUCLEIC ACIDS RESEARCH

Quantitative Analysis of Immune Infiltrates in Primary Melanoma

(2018) Robyn D. Gartrell et al.   Cancer Immunology Research

Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme

(2018) Uchini Kosgodage et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription

(2018) Priyanka Sharma et al.   MOLECULAR CELL

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

(2018) A. E. Yuzhalin et al.   Nature Communications

Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation

(2017) Mandar Bawadekar et al.   JOURNAL OF AUTOIMMUNITY

Macrophage Extracellular Traps: A Scoping Review

(2017) Ryan S. Doster et al.   Journal of Innate Immunity

Development of a Selective Inhibitor of Protein Arginine Deiminase 2

(2017) Aaron Muth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer

(2017) Yi Qu et al.   Nature Chemical Biology

The lncRNA HOXA11-AS functions as a competing endogenous RNA to regulate PADI2 expression by sponging miR-125a-5p in liver metastasis of colorectal cancer

(2017) Dong Chen et al.   Oncotarget

Post-Translational Modification Control of Innate Immunity

(2016) Juan Liu et al.   IMMUNITY

Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

(2016) Yong Hu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma

(2016) G McNee et al.   LEUKEMIA

Differential Use of Human Neutrophil FcγReceptors for Inducing Neutrophil Extracellular Trap Formation

(2016) Omar Rafael Alemán et al.   Journal of Immunology Research

High numbers of macrophages, especially M2-like (CD163-positive), correlate with hyaluronan accumulation and poor outcome in breast cancer

(2015) Satu Tiainen et al.   HISTOPATHOLOGY

Extracellular traps and macrophages: new roles for the versatile phagocyte

(2015) Devin M. Boe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway

(2014) Kin Pong U et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Cancer-related inflammation and treatment effectiveness

(2014) Connie I Diakos et al.   LANCET ONCOLOGY

Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells

(2014) Pei-Chen Hsu et al.   MOLECULES AND CELLS

Targeted H3R26 Deimination Specifically Facilitates Estrogen Receptor Binding by Modifying Nucleosome Structure

(2014) Michael J. Guertin et al.   PLoS Genetics

Mycobacterium tuberculosis Exploits Human Interferon γ to Stimulate Macrophage Extracellular Trap Formation and Necrosis

(2013) Ka-Wing Wong et al.   JOURNAL OF INFECTIOUS DISEASES

Identification of Macrophage Extracellular Trap-Like Structures in Mammary Gland Adipose Tissue: A Preliminary Study

(2013) Sunish Mohanan et al.   Frontiers in Immunology

Mannheimia haemolytica and Its Leukotoxin Cause Macrophage Extracellular Trap Formation by Bovine Macrophages

(2012) Nicole A. Aulik et al.   INFECTION AND IMMUNITY

Potential Role for PAD2 in Gene Regulation in Breast Cancer Cells

(2012) Brian D. Cherrington et al.   PLoS One

Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor   target gene activation

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

(2011) Li Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Subcellular Localization of Peptidylarginine Deiminase 2 and Citrullinated Proteins in Brains of Scrapie-Infected Mice: Nuclear Localization of PAD2 and Membrane Fraction-Enriched Citrullinated Proteins

(2011) Byungki Jang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Peptidylarginine Deiminase 2 Suppresses Inhibitory κB Kinase Activity in Lipopolysaccharide-stimulated RAW 264.7 Macrophages

(2010) Hye Jeong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haloacetamidine-Based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation

(2009) Bryan Knuckley et al.   CHEMBIOCHEM

Dynamic Expression of Peptidylarginine Deiminase 2 in Human Monocytic Leukaemia THP-1 Cells During Macrophage Differentiation

(2009) I. Hojo-Nakashima et al.   JOURNAL OF BIOCHEMISTRY

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE