Chemistry, biochemistry and clinical relevance of the glutamine metabolite α-ketoglutaramate/2-hydroxy-5-oxoproline

Kidney Cancer Risk Associated with Historic Groundwater Trichloroethylene Contamination

(2022) Angeline S. Andrew et al.   International Journal of Environmental Research and Public Health

Comprehensive Metabolic Profiling of MYC-Amplified Medulloblastoma Tumors Reveals Key Dependencies on Amino Acid, Tricarboxylic Acid and Hexosamine Pathways

(2022) Khoa Pham et al.   Cancers

Human cytosolic transaminases: side activities and patterns of discrimination towards physiologically available alternative substrates

(2022) Francesco Caligiore et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

α-Ketoglutaramate—A key metabolite contributing to glutamine addiction in cancer cells

(2022) Arthur J. L. Cooper et al.   Frontiers in Medicine

The intermediate in a nitrate-responsive ω-amidase pathway in plants may signal ammonium assimilation status

(2022) Pat J Unkefer et al.   PLANT PHYSIOLOGY

HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells

(2022) Qiang Qiu et al.   Bioactive Materials

An Unsual Cys‐Glu‐Lys Catalytic Triad is Responsible for the Catalytic Mechanism of the Nitrilase Superfamily: a QM/MM study on Nit2

(2021) Carla S. Silva Teixeira et al.   CHEMPHYSCHEM

Direct Alkylation of Deoxyguanosine by Azaserine Leads to O6-Carboxymethyldeoxyguanosine

(2021) Susanne M. Geisen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment

(2021) Yao-An Shen et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Novel mRNA-Mediated and MicroRNA-Guided Approach to Specifically Eradicate Drug-Resistant Hepatocellular Carcinoma Cell Lines by Se-Methylselenocysteine

(2021) Arun Kumar Selvam et al.   Antioxidants

Preparative Biocatalytic Synthesis of α-Ketoglutaramate

(2021) Maksim Nikulin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification and characterization of a novel glutaminase inhibitor

(2021) Henning Cederkvist et al.   FEBS Open Bio

The mercapturic acid pathway

(2020) Patrick E. Hanna et al.   CRITICAL REVIEWS IN TOXICOLOGY

Synthesis of α-Ketoglutaramic acid

(2020) Dunxin Shen et al.   ANALYTICAL BIOCHEMISTRY

The Metabolic Importance of the Glutaminase II Pathway in Normal and Cancerous Cells

(2020) Thambi Dorai et al.   ANALYTICAL BIOCHEMISTRY

Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer

(2019) Sunag Udupa et al.   PROTEOMICS

High Levels of Glutaminase II Pathway Enzymes in Normal and Cancerous Prostate Suggest a Role in ‘Glutamine Addiction’

(2019) Thambi Dorai et al.   Biomolecules

Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

(2018) Xin-Yu Zhang et al.   Expert Opinion on Drug Discovery

We're Not “DON” Yet: Optimal Dosing and Prodrug Delivery of6-Diazo-5-oxo-L-norleucine

(2018) Kathryn M. Lemberg et al.   MOLECULAR CANCER THERAPEUTICS

The kynurenine pathway and the brain: Challenges, controversies and promises

(2017) Robert Schwarcz et al.   NEUROPHARMACOLOGY

HPLC determination of α-ketoglutaramate [5-amino-2,5-dioxopentanoate] in biological samples

(2016) Yevgeniya I. Shurubor et al.   ANALYTICAL BIOCHEMISTRY

ω-Amidase: an underappreciated, but important enzyme in l-glutamine and l-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases

(2015) Arthur J. L. Cooper et al.   AMINO ACIDS

Se-Methyl-l-selenocysteine Induces Apoptosis via Endoplasmic Reticulum Stress and the Death Receptor Pathway in Human Colon Adenocarcinoma COLO 205 Cells

(2015) Yen-Chen Tung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kynurenine Aminotransferase III and Glutamine Transaminase L Are Identical Enzymes that have CysteineS-Conjugate β-Lyase Activity and Can Transaminate l-Selenomethionine

(2014) John T. Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into the Catalytic Active Site and Activity of Human Nit2/ω-Amidase

(2012) Chin-Hsiang Chien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders

(2011) Tomiko Kuhara et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A GC/MS-based metabolomic approach for diagnosing citrin deficiency

(2011) Tomiko Kuhara et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria

(2011) Cristina Cobzaru et al.   RESEARCH IN MICROBIOLOGY

Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents

(2010) Arthur J. L. Cooper et al.   AMINO ACIDS

Assay and purification of ω-amidase/Nit2, a ubiquitously expressed putative tumor suppressor, that catalyzes the deamidation of the α-keto acid analogues of glutamine and asparagine

(2009) Boris F. Krasnikov et al.   ANALYTICAL BIOCHEMISTRY