ω-Amidase: an underappreciated, but important enzyme in l-glutamine and l-asparagine metabolism; relevance to sulfur and nitrogen metabolism, tumor biology and hyperammonemic diseases

Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement

(2015) Kenneth Hensley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Increased plasma d-2-hydroxyglutarate in isocitrate dehydrogenase 2–mutated blastic plasmacytoid dendritic cell neoplasm

(2015) Dinesh Rakheja et al.   HUMAN PATHOLOGY

Glutaminase activity determines cytotoxicity of l-asparaginases on most leukemia cell lines

(2015) Jean Hugues Parmentier et al.   LEUKEMIA RESEARCH

Evidence that glutamine transaminase and omega-amidase potentially act in tandem to close the methionine salvage cycle in bacteria and plants

(2015) Kenneth W. Ellens et al.   PHYTOCHEMISTRY

Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma

(2015) Boris Ratnikov et al.   Oncotarget

Glutaminase: A Hot Spot For Regulation Of Cancer Cell Metabolism?

(2015)   Oncotarget

Cancer-associated Isocitrate Dehydrogenase 1 (IDH1) R132H Mutation and d-2-Hydroxyglutarate Stimulate Glutamine Metabolism under Hypoxia

(2014) Zachary J. Reitman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kynurenine Aminotransferase III and Glutamine Transaminase L Are Identical Enzymes that have CysteineS-Conjugate β-Lyase Activity and Can Transaminate l-Selenomethionine

(2014) John T. Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine

(2014) Roger F. Butterworth   MOLECULAR GENETICS AND METABOLISM

Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration

(2014) Robert Rejdak et al.   Pharmacological Reports

Identification and characterization of omega-amidase as an enzyme metabolically linked to asparagine transamination in Arabidopsis

(2014) Qianyi Zhang et al.   PHYTOCHEMISTRY

Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells

(2014) Clint A. Stalnecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colorectal cancer derived organotypic spheroids maintain essential tissue characteristics but adapt their metabolism in culture

(2014) Uros Rajcevic et al.   Proteome Science

Targeting Kynurenine Aminotransferase II in Psychiatric Diseases: Promising Effects of an Orally Active Enzyme Inhibitor

(2014) H.-Q. Wu et al.   SCHIZOPHRENIA BULLETIN

Metabolite proofreading, a neglected aspect of intermediary metabolism

(2013) Emile Van Schaftingen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

Structural Insights into the Catalytic Active Site and Activity of Human Nit2/ω-Amidase

(2012) Chin-Hsiang Chien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders

(2011) Tomiko Kuhara et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A GC/MS-based metabolomic approach for diagnosing citrin deficiency

(2011) Tomiko Kuhara et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The N-terminal extension is essential for the formation of the active dimeric structure of liver peroxisomal alanine:glyoxylate aminotransferase

(2011) Riccardo Montioli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria

(2011) Cristina Cobzaru et al.   RESEARCH IN MICROBIOLOGY

Cysteine S-conjugate β-lyases: important roles in the metabolism of naturally occurring sulfur and selenium-containing compounds, xenobiotics and anticancer agents

(2010) Arthur J. L. Cooper et al.   AMINO ACIDS

Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis

(2010) Susan J. Duthie   JOURNAL OF INHERITED METABOLIC DISEASE

Impaired Kynurenine Pathway Metabolism in The Prefrontal Cortex of Individuals With Schizophrenia

(2010) K. V. Sathyasaikumar et al.   SCHIZOPHRENIA BULLETIN

Assay and purification of ω-amidase/Nit2, a ubiquitously expressed putative tumor suppressor, that catalyzes the deamidation of the α-keto acid analogues of glutamine and asparagine

(2009) Boris F. Krasnikov et al.   ANALYTICAL BIOCHEMISTRY

Molecular identification of ω-amidase, the enzyme that is functionally coupled with glutamine transaminases, as the putative tumor suppressor Nit2

(2009) Stéphane Jaisson et al.   BIOCHIMIE

Identification of the putative tumor suppressor Nit2 as ω-amidase, an enzyme metabolically linked to glutamine and asparagine transamination

(2009) Boris F. Krasnikov et al.   BIOCHIMIE

Evidence for genetic heterogeneity in D-2-hydroxyglutaric aciduria

(2009) Martijn Kranendijk et al.   HUMAN MUTATION

Functional Proteomic and Structural Insights into Molecular Recognition in the Nitrilase Family Enzymes†‡

(2008) Katherine T. Barglow et al.   BIOCHEMISTRY

Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II

(2008) Qian Han et al.   BIOSCIENCE REPORTS

Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis

(2008) Franca Rossi et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

l-2-Hydroxyglutaric aciduria, a disorder of metabolite repair

(2008) E. Van Schaftingen et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The Response of Human Colonocytes to Folate Deficiency in Vitro: Functional and Proteomic Analyses

(2008) Susan J. Duthie et al.   JOURNAL OF PROTEOME RESEARCH

Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III

(2008) Q. Han et al.   MOLECULAR AND CELLULAR BIOLOGY