New Approaches for Targeting PCSK9: Small-Interfering Ribonucleic Acid and Genome Editing
Published 2023 View Full Article
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Title
New Approaches for Targeting PCSK9: Small-Interfering Ribonucleic Acid and Genome Editing
Authors
Keywords
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Journal
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
Volume 43, Issue 7, Pages 1081-1092
Publisher
Ovid Technologies (Wolters Kluwer Health)
Online
2023-06-01
DOI
10.1161/atvbaha.122.317963
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Note: Only part of the references are listed.- CRISPR technology: A decade of genome editing is only the beginning
- (2023) Joy Y. Wang et al. SCIENCE
- Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease
- (2023) Jacqueline S. Dron et al. JAMA Cardiology
- Drug delivery systems for RNA therapeutics
- (2022) Kalina Paunovska et al. NATURE REVIEWS GENETICS
- Efficacy and Safety of an Investigational Single-course CRISPR Base Editing Therapy Targeting PCSK9 in Non-human Primate and Mouse Models
- (2022) Richard G. Lee et al. CIRCULATION
- An in vivo CRISPR base editing therapy to inactivate the ANGPTL3 gene: nomination of a development candidate for VERVE-201
- (2022) A Khera et al. EUROPEAN HEART JOURNAL
- 2022 ACC Expert Consensus Decision Pathway on the Role of Nonstatin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk
- (2022) Donald M. Lloyd-Jones et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
- (2022) Christina Reith et al. LANCET
- LDL-C target attainment in secondary prevention of ASCVD in the United States: barriers, consequences of nonachievement, and strategies to reach goals
- (2022) James Underberg et al. POSTGRADUATE MEDICINE
- RNA therapeutics: updates and future potential
- (2022) Caroline Zhang et al. Science China-Life Sciences
- Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9
- (2021) Lili Wang et al. MOLECULAR THERAPY
- Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program
- (2021) Daniel Taliun et al. NATURE
- In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
- (2021) Kiran Musunuru et al. NATURE
- In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels
- (2021) Tanja Rothgangl et al. NATURE BIOTECHNOLOGY
- Adherence and persistence in the use of statins and ezetimibe over 8 years in a real-life study
- (2021) Fiorenzo Santoleri et al. CURRENT MEDICAL RESEARCH AND OPINION
- CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis
- (2021) Julian D. Gillmore et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pre-Clinical Evaluation of the Nanoliposomal antiPCSK9 Vaccine in Healthy Non-Human Primates
- (2021) Amir Abbas Momtazi-Borojeni et al. Vaccines
- ACC/AHA lipid guidelines: Personalized care to prevent cardiovascular disease
- (2020) Cara Reiter-Brennan et al. CLEVELAND CLINIC JOURNAL OF MEDICINE
- The mutational constraint spectrum quantified from variation in 141,456 humans
- (2020) Konrad J. Karczewski et al. NATURE
- Directed evolution of adenine base editors with increased activity and therapeutic application
- (2020) Nicole M. Gaudelli et al. NATURE BIOTECHNOLOGY
- Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
- (2020) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia
- (2020) Frederick J. Raal et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
- (2020) Andrew V. Anzalone et al. NATURE BIOTECHNOLOGY
- Efficacy and Safety of PCSK9 Inhibition With Evolocumab in Reducing Cardiovascular Events in Patients With Metabolic Syndrome Receiving Statin Therapy
- (2020) Prakash Deedwania et al. JAMA Cardiology
- Effect of alirocumab on major adverse cardiovascular events according to renal function in patients with a recent acute coronary syndrome: prespecified analysis from the ODYSSEY OUTCOMES randomized clinical trial
- (2020) José Tuñón et al. EUROPEAN HEART JOURNAL
- Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk
- (2020) Michael J. Domanski et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- CRISPR/Cas9: A preclinical and clinical perspective for the treatment of human diseases
- (2020) Garima Sharma et al. MOLECULAR THERAPY
- siRNA based drug design, quality, delivery and clinical translation
- (2020) Md Abdus Subhan et al. Nanomedicine-Nanotechnology Biology and Medicine
- CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
- (2020) Haydar Frangoul et al. NEW ENGLAND JOURNAL OF MEDICINE
- Association of Genetic Variants Related to Combined Exposure to Lower Low-Density Lipoproteins and Lower Systolic Blood Pressure With Lifetime Risk of Cardiovascular Disease
- (2019) Brian A. Ference et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Therapeutic effect of nanoliposomal PCSK9 vaccine in a mouse model of atherosclerosis
- (2019) Amir Abbas Momtazi-Borojeni et al. BMC Medicine
- Prior Authorization Requirements for Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Across US Private and Public Payers
- (2018) Jalpa A. Doshi et al.
- PCSK9 deficiency reduces insulin secretion and promotes glucose intolerance: the role of the low-density lipoprotein receptor
- (2018) Lorenzo Da Dalt et al. EUROPEAN HEART JOURNAL
- Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol
- (2018) Lili Wang et al. NATURE BIOTECHNOLOGY
- Prior Authorization Requirements for Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors Across US Private and Public Payers
- (2018) Jalpa A. Doshi et al. Circulation-Cardiovascular Quality and Outcomes
- Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
- (2018) Gregory G. Schwartz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel
- (2017) Brian A. Ference et al. EUROPEAN HEART JOURNAL
- The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
- (2017) Christine Landlinger et al. EUROPEAN HEART JOURNAL
- Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease
- (2017) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
- (2017) Kevin Fitzgerald et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis
- (2016) James S. Butler et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Reduction in Total Cardiovascular Events With Ezetimibe/Simvastatin Post-Acute Coronary Syndrome
- (2016) Sabina A. Murphy et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344
- (2015) Ryan G Walker et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events
- (2015) Jennifer G. Robinson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events
- (2015) Marc S. Sabatine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Very Low Levels of Atherogenic Lipoproteins and the Risk for Cardiovascular Events
- (2014) S. Matthijs Boekholdt et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- LDL CHOLESTEROL REDUCTION WITH BMS-962476, AN ADNECTIN INHIBITOR OF PCSK9: RESULTS OF A SINGLE ASCENDING DOSE STUDY
- (2014) Evan A. Stein et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
- (2013) Kevin Fitzgerald et al. LANCET
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
- (2008) M. Frank-Kamenetsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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