Fibronectin-based scaffold domain proteins that bind myostatin: a patent evaluation of WO2014043344

A Phase 1/2a Follistatin Gene Therapy Trial for Becker Muscular Dystrophy

(2015) Jerry R Mendell et al.   MOLECULAR THERAPY

A myostatin inhibitor (propeptide-Fc) increases muscle mass and muscle fiber size in aged mice but does not increase bone density or bone strength

(2013) Phonepasong Arounleut et al.   EXPERIMENTAL GERONTOLOGY

An Antibody Blocking Activin Type II Receptors Induces Strong Skeletal Muscle Hypertrophy and Protects from Atrophy

(2013) E. Lach-Trifilieff et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2

(2013) Y.-S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myostatin inhibitors as therapies for muscle wasting associated with cancer and other disorders

(2013) Rosamund C. Smith et al.   Current Opinion in Supportive and Palliative Care

The central role of myostatin in skeletal muscle and whole body homeostasis

(2012) B. Elliott et al.   Acta Physiologica

Characterization of Follistatin-Type Domains and Their Contribution to Myostatin and Activin A Antagonism

(2012) Jennifer N. Cash et al.   MOLECULAR ENDOCRINOLOGY

A single ascending-dose study of muscle regulator ace-031 in healthy volunteers

(2012) Kenneth M. Attie et al.   MUSCLE & NERVE

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy

(2011) Emidio E. Pistilli et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase I and Pharmacokinetic Study of CT-322 (BMS-844203), a Targeted Adnectin Inhibitor of VEGFR-2 Based on a Domain of Human Fibronectin

(2011) A. W. Tolcher et al.   CLINICAL CANCER RESEARCH

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease

(2011) Liping Zhang et al.   FASEB JOURNAL

Structure of Myostatin·Follistatin-like 3

(2011) Jennifer N. Cash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Soluble activin receptor type IIB increases forward pulling tension in the mdx mouse

(2011) C. George Carlson et al.   MUSCLE & NERVE

Characterization of the Ligand Binding Functionality of the Extracellular Domain of Activin Receptor Type IIB

(2010) Dianne Sako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of Myostatin Pathway Interference and Dystrophin Rescue Enhances Tetanic and Specific Force in Dystrophic mdx Mice

(2010) Julie Dumonceaux et al.   MOLECULAR THERAPY

Systemic Myostatin Inhibition via Liver-Targeted Gene Transfer in Normal and Dystrophic Mice

(2010) Kevin J. Morine et al.   PLoS One

Adnectins: engineered target-binding protein therapeutics

(2010) D. Lipovsek   PROTEIN ENGINEERING DESIGN & SELECTION

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

FN3: a new protein scaffold reaches the clinic

(2009) Laird Bloom et al.   DRUG DISCOVERY TODAY

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

(2009) Jennifer N Cash et al.   EMBO JOURNAL

Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease

(2009) Louise R. Rodino-Klapac et al.   MUSCLE & NERVE

Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates

(2009) J. Kota et al.   Science Translational Medicine

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

(2008) Kathryn R. Wagner et al.   ANNALS OF NEUROLOGY

Crystal Structure Analysis Reveals How the Chordin Family Member Crossveinless 2 Blocks BMP-2 Receptor Binding

(2008) Jin-li Zhang et al.   DEVELOPMENTAL CELL

The Structure of FSTL3·Activin A Complex

(2008) Robin Stamler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single muscle fiber contractile properties in adults with muscular dystrophy treated with MYO-029

(2008) Lisa S. Krivickas et al.   MUSCLE & NERVE

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors

(2008) A. M. Haidet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA