Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site

Comprehensive in vitro analysis evaluating the variable drug–drug interaction risk of rifampicin compared to rifabutin

(2023) Julie Nilles et al.   ARCHIVES OF TOXICOLOGY

Physiology‐based pharmacokinetic modelling and experimental data suggest that rifabutin alters dolutegravir kinetics by both P‐glycoprotein induction and concurrent inhibition

(2023) Dirk Theile et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR)

(2023) Zuzana Rania Brožová et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor

(2021) Michael P. Smolinski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1

(2020) Kamil Nosol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 2: Prediction of Decreased Substrate Exposure After Rifabutin or Carbamazepine

(2018) Justin D. Lutz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 3A Induction Predicts P-glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin

(2018) Justin D. Lutz et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

(2018) Amer Alam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Large-scale prediction of binding affinity in protein-small ligand complexes: the PRODIGY-LIG web server

(2018) Anna Vangone et al.   BIOINFORMATICS

Impact of rifampicin-inhibitable transport on the liver distribution and tissue kinetics of erlotinib assessed with PET imaging in rats

(2018) Dorra Amor et al.   EJNMMI Research

Inhibitory Interaction Potential of 22 Antituberculosis Drugs on Organic Anion and Cation Transporters of the SLC22A Family

(2016) M. Masud Parvez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Docking Characterizes Substrate-Binding Sites and Efflux Modulation Mechanisms within P-Glycoprotein.

(2013) Ricardo J. Ferreira et al.   Journal of Chemical Information and Modeling

In-vitro evaluation of chronic alcohol effects on expression of drug-metabolizing and drug-transporting proteins

(2013) Dirk Theile et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Influence of sildenafil and tadalafil on the enzyme- and transporter-inducing effects of bosentan and ambrisentan in LS180 cells

(2012) Johanna Weiss et al.   BIOCHEMICAL PHARMACOLOGY

The mitochondrial fluorescent dye rhodamine 123 is a high-affinity substrate for organic cation transporters (OCTs) 1 and 2

(2012) Elodie Jouan et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Characterization of Rhodamine-123 as a Tracer Dye for Use In In vitro Drug Transport Assays

(2012) Samantha Forster et al.   PLoS One

Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro

(2011) Johanna Weiss et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rifampin's Acute Inhibitory and Chronic Inductive Drug Interactions: Experimental and Model-Based Approaches to Drug–Drug Interaction Trial Design

(2010) M L Reitman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impact of drug transporters on cellular resistance towards saquinavir and darunavir

(2010) S. K. Konig et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Update on Rifampin and Rifabutin Drug Interactions

(2009) Anne M. Baciewicz et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Pharmacogenetics of the organic anion transporting polypeptide 1A2

(2009) Ryan M Franke et al.   PHARMACOGENOMICS

Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors

(2008) A. Gupta et al.   DRUG METABOLISM AND DISPOSITION

Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors

(2007) Johanna Weiss et al.   EUROPEAN JOURNAL OF PHARMACOLOGY