Research progress of CXCR3 inhibitors

The CCR5 and CXCR3 Pathways in Hepatitis C Virus Liver Transplanted Recipients Treated by a Direct Antiviral Agent Regimen: Informative Kinetics Profiles

(2021) Giuseppe Colucci et al.   VIRAL IMMUNOLOGY

HIV Tat-Mediated Induction of Monocyte Transmigration Across the Blood–Brain Barrier: Role of Chemokine Receptor CXCR3

(2021) Fang Niu et al.   Frontiers in Cell and Developmental Biology

CXCR3 Ligands in Cancer and Autoimmunity, Chemoattraction of Effector T Cells, and Beyond

(2020) Nathan Karin   Frontiers in Immunology

Tumor inhibition or tumor promotion? The duplicity of CXCR3 in cancer

(2020) Eleonora Russo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Evaluating the Role of CXCR3 in Pain Modulation: A Literature Review

(2020) Ashwag Yagoub Aloyouny et al.   Journal of Pain Research

Advances of CCR5 antagonists: From small molecules to macromolecules

(2020) Baowen Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The CXCL11‐CXCR3A axis influences the infiltration of CD274 and IDO1 in oral squamous cell carcinoma

(2020) Xin Wang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

The Role of CXCR3 in Neurological Diseases

(2019) Ya-Qun Zhou et al.   Current Neuropharmacology

Carnosic Acid Inhibits CXCR3 Ligands Production in IL-27-Stimulated Human Oral Epithelial Cells

(2019) Ikuko Hosokawa et al.   INFLAMMATION

CXCR3-CXCL9: It’s All in the Tumor

(2019) Etienne Humblin et al.   IMMUNITY

CXCL4 and CXCL4L1 in cancer

(2018) Pieter Ruytinx et al.   CYTOKINE

Chemokines beyond chemo-attraction: CXCL10 and its significant role in cancer and autoimmunity

(2018) Nathan Karin et al.   CYTOKINE

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CXCL9, CXCL10, CXCL11, and their receptor (CXCR3) in neuroinflammation and neurodegeneration

(2018) Olga Koper et al.   Advances in Clinical and Experimental Medicine

Structure and dynamics of GPCR signaling complexes

(2018) Daniel Hilger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CXCR3 expression in colorectal cancer cells enhanced invasion through preventing CXCR4 internalization

(2018) Jingjing Jin et al.   EXPERIMENTAL CELL RESEARCH

The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction

(2018) Veronika Szentes et al.   Frontiers in Immunology

C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways

(2017) Jeffrey S. Smith et al.   MOLECULAR PHARMACOLOGY

Induction of cathepsin B by the CXCR3 chemokines CXCL9 and CXCL10 in human breast cancer cells

(2017) Holger Bronger et al.   Oncology Letters

Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis?

(2017) Soledad Urra et al.   Oncotarget

CXCR3 mediates ascites-directed tumor cell migration and predicts poor outcome in ovarian cancer patients

(2017) C Windmüller et al.   Oncogenesis

Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases

(2016) R. Altara et al.   CLINICAL SCIENCE

CXCL10/CXCR3 signaling mobilized-regulatory T cells promote liver tumor recurrence after transplantation

(2016) Chang Xian Li et al.   JOURNAL OF HEPATOLOGY

CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells

(2016) Chen-Yen Chung et al.   Journal of Neuroinflammation

CXCR3A contributes to the invasion and metastasis of gastric cancer cells

(2016) Chenggang Yang et al.   ONCOLOGY REPORTS

Increased CXCR3 Expression of Infiltrating Plasma Cells in Hunner Type Interstitial Cystitis

(2016) Yoshiyuki Akiyama et al.   Scientific Reports

CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK-779

(2015) Belinda Nedjai et al.   BRITISH JOURNAL OF PHARMACOLOGY

CXCR3 ligands in disease and therapy

(2015) Katrien Van Raemdonck et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets

(2015) Nathan Karin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: Improved PK, hERG and metabolic profiles

(2014) Anilkumar G. Nair et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Divergent roles of CXCR3 isoforms in promoting cancer stem-like cell survival and metastasis

(2014) Yanchun Li et al.   BREAST CANCER RESEARCH AND TREATMENT

The Association of CXCR3 and Renal Cell Carcinoma Metastasis

(2014) Takanobu Utsumi et al.   JOURNAL OF UROLOGY

A selective and potent CXCR3 antagonist SCH 546738 attenuates the development of autoimmune diseases and delays graft rejection

(2012) Chung-Her Jenh et al.   BMC IMMUNOLOGY

Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes

(2012) AO Watts et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of CXCR3 and CXCR4 in colorectal cancer metastasis

(2012) Teppei Murakami et al.   INTERNATIONAL JOURNAL OF CANCER

Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion

(2012) Qian Wu et al.   Molecular Cancer

Special ergolines efficiently inhibit the chemokine receptor CXCR3 in blood

(2011) Gebhard Thoma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of potent and specific CXCR3 antagonists

(2011) Xiaoqi Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a novel series of CXCR3 antagonists

(2010) Stefano Crosignani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

II. SAR studies of pyridyl–piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists

(2010) Yuefei Shao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CXCR3, Inflammation, and Autoimmune Diseases

(2009) Stéphanie Lacotte et al.   Annals of the New York Academy of Sciences

Novel CXCR3 antagonists with a piperazinyl-piperidine core

(2009) Brian F. McGuinness et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a series of quinazolinone-derived antagonists of CXCR3

(2009) Jiwen Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Special ergolines are highly selective, potent antagonists of the chemokine receptor CXCR3: Discovery, characterization and preliminary SAR of a promising lead

(2009) Gebhard Thoma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Imidazo-pyrazine derivatives as potent CXCR3 antagonists

(2009) Xiaohui Du et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Organ-specific inhibition of metastatic colon carcinoma by CXCR3 antagonism

(2009) B Cambien et al.   BRITISH JOURNAL OF CANCER

Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs

(2009) Emmanuelle Pradelli et al.   INTERNATIONAL JOURNAL OF CANCER

CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model

(2009) X. Ma et al.   MOLECULAR CANCER THERAPEUTICS

Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-  and CXCR3 Ligands

(2008) M. Wendel et al.   CANCER RESEARCH

An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N- -N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing

(2008) G. R. Tonn et al.   DRUG METABOLISM AND DISPOSITION

Activation of p38MAPK mediates the angiostatic effect of the chemokine receptor CXCR3-B

(2008) Ilaria Petrai et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors

(2008) D. Verzijl et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS