Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases

(2015) Maartje C P Cleophas et al.   ANNALS OF THE RHEUMATIC DISEASES

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation

(2015) Yang Sun et al.   BIOCHEMICAL PHARMACOLOGY

Hydroxysafflor yellow A attenuate lipopolysaccharide-induced endothelium inflammatory injury

(2015) Ming Jin et al.   Chinese Journal of Integrative Medicine

Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1β via the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a pos

(2015) P. Ruscitti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Kinase Inhibitors with Redox and Anti-inflammatory Activities

(2015) Nina Ivanovska et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Hydroxysafflor yellow A exerts neuroprotective effects in cerebral ischemia reperfusion-injured mice by suppressing the innate immune TLR4-inducing pathway

(2015) Yanni Lv et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation

(2015) Wenjie Guo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

IL-18 Triggered by the Nlrp3 Inflammasome Induces Host Innate Resistance in a Pulmonary Model of Fungal Infection

(2015) Natália Ketelut-Carneiro et al.   JOURNAL OF IMMUNOLOGY

Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats

(2015) Yanhao He et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Chronic, not acute, skin-specific inflammation promotes thrombosis in psoriasis murine models

(2015) Jackelyn B. Golden et al.   Journal of Translational Medicine

ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury

(2015) Shichao Han et al.   MEDIATORS OF INFLAMMATION

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

(2015) Pervinder Sagoo et al.   NATURE MEDICINE

Xanthine oxidoreductase regulates macrophage IL1β secretion upon NLRP3 inflammasome activation

(2015) Annette Ives et al.   Nature Communications

Helicobacter pylori induces IL-1β and IL-18 production in human monocytic cell line through activation of NLRP3 inflammasome via ROS signaling pathway

(2015) Xiang Li et al.   Pathogens and Disease

Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome

(2014) Bo-Zong Shao et al.   CNS Neuroscience & Therapeutics

Activation of the Epidermal Growth Factor Receptor in Macrophages Regulates Cytokine Production and Experimental Colitis

(2014) N. Lu et al.   JOURNAL OF IMMUNOLOGY

Gene expression profiling in sepsis: timing, tissue, and translational considerations

(2014) David M. Maslove et al.   TRENDS IN MOLECULAR MEDICINE

iDrug: a web-accessible and interactive drug discovery and design platform

(2014) Xia Wang et al.   Journal of Cheminformatics

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

(2014) Johji Nomura et al.   Scientific Reports

Inhibitory Effect of Hydroxysafflor Yellow A on Mouse Skin Photoaging Induced by Ultraviolet Irradiation

(2013) Song-Zhi Kong et al.   REJUVENATION RESEARCH

The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β

(2012) Nathan A. Bracey et al.   EXPERIMENTAL PHYSIOLOGY

Sevoflurane Combined with ATP Activates Caspase-1 and Triggers Caspase-1-Dependent Pyroptosis in Murine J774 Macrophages

(2012) Yue Jin et al.   INFLAMMATION

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Caspase-1-Processed Cytokines IL-1  and IL-18 Promote IL-17 Production by    and CD4 T Cells That Mediate Autoimmunity

(2011) S. J. Lalor et al.   JOURNAL OF IMMUNOLOGY

PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

(2010) Xiaofeng Liu et al.   NUCLEIC ACIDS RESEARCH

Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers

(2009) Zhifu Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of All-Trans Retinoic Acid on Th1- and Th2-Related Chemokines Production in Monocytes

(2008) Yu-Chien Tsai et al.   INFLAMMATION

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY