The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure

(2012) Benjamin W. Van Tassell et al.   PLoS One

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION

When are pro-inflammatory cytokines SAFE in heart failure?

(2011) S. Lecour et al.   EUROPEAN HEART JOURNAL

Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages

(2011) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

New Targets to Treat the Structural Remodeling of the Myocardium

(2011) Arantxa González et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The inflammasome promotes adverse cardiac remodeling following acute myocardial infarction in the mouse

(2011) E. Mezzaroma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Risk Factors to Structural Heart Disease: The Role of Inflammation

(2011) Andreas P. Kalogeropoulos et al.   Heart Failure Clinics

Interleukin-1 Blockade With Anakinra to Prevent Adverse Cardiac Remodeling After Acute Myocardial Infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot Study)

(2010) Antonio Abbate et al.   AMERICAN JOURNAL OF CARDIOLOGY

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

TNF-α and IL-1β increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes

(2010) David J. Duncan et al.   CELL CALCIUM

Proinflammatory cytokines in heart failure: double-edged swords

(2010) Mona Hedayat et al.   HEART FAILURE REVIEWS

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

The role of IL-1 in the pathogenesis of heart disease

(2009) Marcin Bujak et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

iNOS in cardiac myocytes plays a critical role in death in a murine model of hypertrophy induced by calcineurin

(2008) Julie R. Somers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Early and Long-term Outcomes of Heart Failure in Elderly Persons, 2001-2005

(2008) Lesley H. Curtis et al.   ARCHIVES OF INTERNAL MEDICINE

Anakinra, a Recombinant Human Interleukin-1 Receptor Antagonist, Inhibits Apoptosis in Experimental Acute Myocardial Infarction

(2008) Antonio Abbate et al.   CIRCULATION