Yangjing Capsule Increases Testosterone Production through SET/PI3K/Akt Pathway in Leydig Cell

Single-cell analysis of human testis aging and correlation with elevated body mass index

(2022) Xichen Nie et al.   DEVELOPMENTAL CELL

COVID-19 disrupts spermatogenesis through the oxidative stress pathway following induction of apoptosis

(2021) Negin Moghimi et al.   APOPTOSIS

MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes

(2021) Li Hu et al.   MOLECULAR MEDICINE

Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

(2020) Robert F. Hillary et al.   Genome Medicine

Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell proliferation of Leydig cells

(2020) Junke Wang et al.   JOURNAL OF HAZARDOUS MATERIALS

Targeting SET to restore PP2A activity disrupts an oncogenic CIP2A-feedforward loop and impairs triple negative breast cancer progression

(2019) Chun-Yu Liu et al.   EBioMedicine

Yeast screening system reveals the inhibitory mechanism of cancer cell proliferation by benzyl isothiocyanate through down-regulation of Mis12

(2019) Naomi Abe-Kanoh et al.   Scientific Reports

Mechanisms of Yangjing capsule in Leydig cell apoptosis and testosterone synthesis via promoting StAR expression

(2018) Dalin Sun et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Leydig cells: formation, function, and regulation†

(2018) Barry R Zirkin et al.   BIOLOGY OF REPRODUCTION

The SET protein promotes androgen production in testicular Leydig cells

(2018) B. Zhang et al.   Andrology

New Insights into Protein Kinase B/Akt Signaling: Role of Localized Akt Activation and Compartment-Specific Target Proteins for the Cellular Radiation Response

(2018) Klaudia Szymonowicz et al.   Cancers

Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL

(2018) Mario Angelo Pagano et al.   LEUKEMIA

Yangjing Capsule extract promotes proliferation of GC-1 spg cells via up-regulated POU3F1 pathway

(2017) Baofang Jin et al.   BioScience Trends

Dysfunctional telomeres induce p53-dependent and independent apoptosis to compromise cellular proliferation and inhibit tumor formation

(2016) Yang Wang et al.   AGING CELL

Protective Effect of Adrenomedullin on Rat Leydig Cells from Lipopolysaccharide-Induced Inflammation and Apoptosis via the PI3K/Akt Signaling Pathway ADM on Rat Leydig Cells from Inflammation and Apoptosis

(2016) Pang-Hu Zhou et al.   MEDIATORS OF INFLAMMATION

The Stimulative Effect of Yangjing Capsule on Testosterone Synthesis through Nur77 Pathway in Leydig Cells

(2015) Yalong Gu et al.   Evidence-based Complementary and Alternative Medicine

Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer

(2015) Hao Liu et al.   Oncotarget

Expression of the SET protein in testes of mice at different developmental stages

(2014) Yu-Gui Cui et al.   ASIAN JOURNAL OF ANDROLOGY

The total number of Leydig and Sertoli cells in the testes of men across various age groups - a stereological study

(2014) Peter M. Petersen et al.   JOURNAL OF ANATOMY

Apoptosis Regulation at the Mitochondrial Outer Membrane

(2013) Laura A. Gillies et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Male hypogonadism

(2013) Shehzad Basaria   LANCET

SET/PP2A system regulates androgen production in ovarian follicles in vitro

(2013) Ling-Ling Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Effects of the Yangjing Capsule Extract on Steroidogenesis and Apoptosis in Mouse Leydig Cells

(2012) Dalin Sun et al.   Evidence-based Complementary and Alternative Medicine

Protein Phosphatase 2A Catalytic Subunit α (PP2Acα) Maintains Survival of Committed Erythroid Cells in Fetal Liver Erythropoiesis through the STAT5 Pathway

(2011) Weiqian Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Investigation, treatment and monitoring of late-onset hypogonadism in males

(2008) C Wang et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY