Exosomes: The New Kid on the Block in Orthobiologics

Exosomes Derived From Kartogenin-Preconditioned Mesenchymal Stem Cells Promote Cartilage Formation and Collagen Maturation for Enthesis Regeneration in a Rat Model of Chronic Rotator Cuff Tear

(2023) Jiangyu Cai et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”

(2023) Wei Seong Toh et al.   CYTOTHERAPY

Registered clinical trials investigating treatment with cell-derived extracellular vesicles: a scoping review

(2023) An Duong et al.   CYTOTHERAPY

Qualification of a multidonor mixed lymphocyte reaction assay for the functional characterization of immunomodulatory extracellular vesicles

(2023) Michel Bremer et al.   CYTOTHERAPY

Platelet-Derived Exosomes Alleviate Knee Osteoarthritis by Attenuating Cartilage Degeneration and Subchondral Bone Loss

(2023) Chenyue Xu et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Comparative Effects of Exosomes and Ectosomes Isolated From Adipose-Derived Mesenchymal Stem Cells on Achilles Tendinopathy in a Rat Model

(2022) Tengjing Xu et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

(2022) Xiuming Liang et al.   Journal of Extracellular Vesicles

The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis

(2021) Litao Yan et al.   Clinical and Translational Medicine

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

(2021) Mario Gimona et al.   CYTOTHERAPY

Mesenchymal Stem Cell-Derived Exosomes Protect Muscle Loss by miR-145-5p Activity Targeting Activin A Receptors

(2021) Kyung-Ah Cho et al.   Cells

Bone marrow mesenchymal stem cell-derived exosomes promote tendon regeneration by facilitating the proliferation and migration of endogenous tendon stem/progenitor cells

(2020) Huilei Yu et al.   Acta Biomaterialia

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

(2019) Shipin Zhang et al.   BIOMATERIALS

miR-100-5p-abundant exosomes derived from infrapatellar fat pad MSCs protect articular cartilage and ameliorate gait abnormalities via inhibition of mTOR in osteoarthritis

(2019) Jiangyi Wu et al.   BIOMATERIALS

MSC exosome works through a protein-based mechanism of action

(2018) Wei Seong Toh et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Biologic Approaches in Sports Medicine

(2016) Scott A. Rodeo   AMERICAN JOURNAL OF SPORTS MEDICINE

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

(2015) Yoshihiro Nakamura et al.   FEBS LETTERS

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine