A report on the International Society for Cell & Gene Therapy 2022 Scientific Signature Series, “Therapeutic advances with native and engineered human extracellular vesicles”

Mesenchymal Stem Cell Exosomes Promote Functional Osteochondral Repair in a Clinically Relevant Porcine Model

(2022) Shipin Zhang et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes

(2022) Jia Tong Loh et al.   CYTOTHERAPY

Extracellular vesicles engineered to bind albumin demonstrate extended circulation time and lymph node accumulation in mouse models

(2022) Xiuming Liang et al.   Journal of Extracellular Vesicles

Perinatal derivatives: How to best validate their immunomodulatory functions

(2022) Andrea Papait et al.   Frontiers in Bioengineering and Biotechnology

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation

(2021) Bin Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

(2021) Akaitz Dorronsoro et al.   AGING CELL

Critical considerations for the development of potency tests for therapeutic applications of mesenchymal stromal cell-derived small extracellular vesicles

(2021) Mario Gimona et al.   CYTOTHERAPY

Exosome-based delivery of super-repressor IκBα ameliorates kidney ischemia-reperfusion injury

(2021) Seonghun Kim et al.   KIDNEY INTERNATIONAL

First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles

(2021) Athanasia Warnecke et al.   Journal of Extracellular Vesicles

Implantation of the clinical-grade human neural stem cell line, CTX0E03 , rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease

(2020) Yongwoo Yoon et al.   STEM CELLS

Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality

(2020) Hojun Choi et al.   Science Advances

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis

(2020) Kyong-Oh Shin et al.   Cells

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury

(2020) Nicole Kaminski et al.   Frontiers in Cellular Neuroscience

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo

(2020) Athanasia Warnecke et al.   Clinical and Translational Medicine

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

(2019) Shipin Zhang et al.   BIOMATERIALS

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

(2019) Kenneth W. Witwer et al.   Journal of Extracellular Vesicles

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

(2018) Shipin Zhang et al.   BIOMATERIALS

Exosomes derived from human adipose tissue-derived mesenchymal stem cells alleviate atopic dermatitis

(2018) Byong Seung Cho et al.   Stem Cell Research & Therapy

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

(2016) Nambin Yim et al.   Nature Communications

Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology

(2016) Anton Selich et al.   Stem Cells Translational Medicine

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

(2012) Mitra Lavasani et al.   Nature Communications

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

(2011) Tian Chen et al.   Journal of Translational Medicine