ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake

Induction of apoptosis and autosis in cardiomyocytes by the combination of homocysteine and copper via NOX-mediated p62 expression

(2022) Ran Yin et al.   Cell Death Discovery

Copper induces cell death by targeting lipoylated TCA cycle proteins

(2022) Peter Tsvetkov et al.   SCIENCE

MicroRNA-301a-3p promotes diabetic retinopathy via regulation of six-transmembrane epithelial antigen of prostate 4

(2021) Yingmin Wang et al.   INFLAMMATION RESEARCH

Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin

(2021) Young-Tae Lee et al.   Nature Communications

Single-cell transcriptome analysis reveals cellular heterogeneity in the ascending aortas of normal and high-fat diet-fed mice

(2021) Hao Kan et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

(2021) Suowen Xu et al.   PHARMACOLOGICAL REVIEWS

SMYD2‐mediated TRAF2 methylation promotes the NF‐κB signaling pathways in inflammatory diseases

(2021) Weijun Wu et al.   Clinical and Translational Medicine

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

(2020) Yun Liao et al.   Nature Communications

ASH2L is involved in promotion of endometrial cancer progression via upregulation of PAX2 transcription

(2020) Kai Zeng et al.   CANCER SCIENCE

NLRP3 inflammasome-mediated pyroptosis contributes to the pathogenesis of non-ischemic dilated cardiomyopathy

(2020) Cheng Zeng et al.   Redox Biology

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Inflammation accelerates copper‐mediated cytotoxicity through induction of six‐transmembrane epithelial antigens of prostate 4 expression

(2020) Cen Jiang et al.   IMMUNOLOGY AND CELL BIOLOGY

Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1

(2020) Tianran Zhang et al.   Redox Biology

Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway

(2019) Chao Niu et al.   Autophagy

Association between plasma concentration of copper and gestational diabetes mellitus

(2019) Peiyun Li et al.   CLINICAL NUTRITION

Fra-1 plays a critical role in angiotensin II–induced vascular senescence

(2019) Di Yang et al.   FASEB JOURNAL

Resveratrol and Vascular Function

(2019) Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma

(2019) Yi-Ju Wu et al.   Cell Death & Disease

Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network

(2019) Ping-Hsing Tsai et al.   NUCLEIC ACIDS RESEARCH

Acute copper overload induces vascular dysfunction in aortic rings due to endothelial oxidative stress and increased nitric oxide production

(2018) Karolini Zuqui Nunes et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies

(2018) Raminderjit Kaur et al.   Cardiovascular Diabetology

Wilson disease

(2018) Anna Członkowska et al.   Nature Reviews Disease Primers

Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction

(2018) Wout Oosterheert et al.   Nature Communications

Copper induces oxidative stress and apoptosis through mitochondria-mediated pathway in chicken hepatocytes

(2018) Fan Yang et al.   TOXICOLOGY IN VITRO

STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper

(2017) Rachel T Scarl et al.   JOURNAL OF ENDOCRINOLOGY

Alterations of serum trace elements in patients with type 2 diabetes

(2017) Hongmei Zhang et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Steap4 attenuates high glucose and S100B-induced effects in mesangial cells

(2015) Chao-Tang Chuang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Puerarin suppresses high glucose-induced MCP-1 expression via modulating histone methylation in cultured endothelial cells

(2015) Peng Han et al.   LIFE SCIENCES

Absent, Small or Homeotic 2-like Protein (ASH2L) Enhances the Transcription of the Estrogen Receptor α Gene through GATA-binding Protein 3 (GATA3)

(2014) Jin Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Bone Morphogenic Protein 4 Restores Endothelial Function in db/db Diabetic Mice

(2013) Yang Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucose-independent persistence of PAI-1 gene expression and H3K4 tri-methylation in type 1 diabetic mouse endothelium: Implication in metabolic memory

(2013) Fumihiko Takizawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human

(2011) Y.-h. Takahashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper and homocysteine in cardiovascular diseases

(2010) Y. James Kang   PHARMACOLOGY & THERAPEUTICS