Article
Biochemistry & Molecular Biology
Yaser Peymanfar, Faranak Mahjour, Neha Shrestha, Ana de la Cueva, Ying Chen, Shengyuan Huang, Kathrin H. Kirsch, Xiaozhe Han, Philip C. Trackman
Summary: Oral cancer, primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%, is more common in humans carrying a polymorphism in the propeptide region of lysyl oxidase (LOX). Knockin mice carrying the same polymorphism are more susceptible to lesion development. The presence of wildtype LOX-PP in humans and mice has a tumor-inhibitory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ryuhei Takemoto, Tetsuro Kamiya, Taku Atobe, Hirokazu Hara, Tetsuo Adachi
Summary: In M2-like macrophages, both HIF1α and STAT3 are essential for LOX induction, while the loss of FOXO1 facilitates HIF1α binding to the lox promoter region, promoting LOX induction.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nataliya Migulina, Gavin Tjin, Alen Faiz, Theo Borghuis, Fenghua Zhao, Hans J. Kaper, Marit Metzlar, Eline van Dijk, Prashant K. Sharma, Wim Timens, Reinoud Gosens, Corry-Anke Brandsma, Janette K. Burgess
Summary: This study investigated the effects of smoking and COPD on LOs gene and protein expression in the airways and found that LOs alterations may be related to smoking and contribute to impaired airway function in COPD, providing potential novel targets for prevention or treatment of small airways changes in COPD.
Review
Chemistry, Analytical
Min Feng, Xue Li, Xiaodan Zhang, Yuming Huang
Summary: Nanozymes are nanomaterials with biological enzyme activity that combine the advantages of nanomaterials and biological enzymes. Most nanozyme-based sensing platforms are peroxidase-like nanozymes, which can affect detection sensitivity and accuracy. The use of unstable H2O2 in peroxidase-like catalytic reactions can also pose reproducibility challenges. This review discusses the development and analytical applications of oxidase-like nanozymes, including their possible mechanisms and the opportunities and challenges they face. Developing high activity oxidase-like nanozymes will be beneficial for expanding their analytical applications.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Oncology
Sylvain D. Vallet, Coline Berthollier, Romain Salza, Laurent Muller, Sylvie Ricard-Blum
Summary: The study aimed to build and analyze the interaction network of the LOX family members, identifying rewiring in cancer. Computational analyses revealed the network's involvement in various cellular processes and its functional switch in colorectal carcinoma.
Article
Chemistry, Multidisciplinary
Wenting Cheng, Lei Zhou, Kai Hu, Dehua Kong, Wei Huang, Chuanjun Xu, Hao Li, Jinlong Li
Summary: Extracellular matrix (ECM) enzymes such as lysyl oxidase (LOX) provide a new way to contain cancer invasion, and a newly developed molecular probe can interact with target enzymes more interactively to modulate their catalytic ability. This biomimetic biosensing process can potentially be used to evaluate ECM-related tumor invasiveness in the future.
Article
Biochemistry & Molecular Biology
Alex A. Meier, Eden P. Go, Hee-Jung Moon, Heather Desaire, Minae Mure
Summary: This study conducted a mass spectrometry-based disulfide mapping analysis to explore the disulfide bond structure of recombinant LOXL2. The results revealed a conserved set of five disulfide bonds in both the precursor and mature forms of LOXL2, while another set of four alternative disulfide bonds, detected in low abundance, was not associated with mature LOXL2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Gokhan Bahcecioglu, Xiaoshan Yue, Erin Howe, Ian Guldner, M. Sharon Stack, Harikrishna Nakshatri, Siyuan Zhang, Pinar Zorlutuna
Summary: The study reveals that aging ECM can drive normal mammary epithelial cells to a more invasive and cancer-like phenotype, and enhance motility and invasiveness in breast cancer cells. Different responses of cells to young and aged ECMs may lead to the identification of new targets for cancer treatment and prevention.
Article
Medicine, General & Internal
Jinfeng Zhu, Chen Luo, Jiefeng Zhao, Xiaojian Zhu, Kang Lin, Fanqin Bu, Zhonglin Yu, Feilong Zou, Zhengming Zhu
Summary: The study revealed that high expression of LOX in gastric cancer tissues is significantly associated with poor overall survival, LOX overexpression is closely correlated with T-stage progression in gastric cancer, and LOX is an independent factor affecting the prognosis of gastric cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alex A. Meier, Krzysztof Kuczera, Minae Mure
Summary: This study generated a 3D-predicted structure of the C-terminal amine oxidase domain of LOXL2 and discussed the active site environment surrounding LTQ and Cu2+.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jinwon Park, Jung Suk Kim, Geon Yang, Hobin Lee, Gayong Shim, Jaiwoo Lee, Yu Kyoung Oh
Summary: The researchers designed LOX-responsive nanoparticles to interact with the collagen matrix in the tumor microenvironment. In vitro experiments showed that these nanoparticles could bind to LOX-secreting CT26 cells, but this binding was blocked by a LOX inhibitor. In mouse experiments, the addition of the LOX inhibitor did not significantly change the antitumor efficacy of the nanoparticles. However, without the LOX inhibitor, a single administration of the nanoparticles provided sustained responsiveness to near-infrared irradiation and ablation of primary tumors.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Kosuke Yamaguchi, Masanori Itakura, Roma Kitazawa, Sei-Young Lim, Koji Nagata, Takahiro Shibata, Mitsugu Akagawa, Koji Uchida
Summary: The study found that polyphenols, especially catechol-type polyphenols, exhibit lysyl oxidase-like activity and mediate oxidative deamination of lysine residues in proteins. The oxidation products of lysine were identified, and it was observed that the reaction was mediated by some polyphenols, especially o-diphenolic-type polyphenols, in the presence of copper ions. The natural immunoglobulin M monoclonal antibody recognized these oxidation products, indicating a potential role in innate immune response.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Han Young Kim, Mihee Jo, Ju A. La, Youngjin Choi, Eun Chul Cho, Su Hee Kim, Youngmee Jung, Kwangmeyung Kim, Ju Hee Ryu
Summary: This study demonstrates sensitive detection of LOX levels in tumor microenvironments using peptide-functionalized gold nanoprobes. The method shows high specificity to LOX and does not exhibit color changes in the presence of other enzymes. The developed LS-AuNPs can be used for predicting tumor stiffness and anticancer drug resistance based on LOX levels.
Article
Oncology
Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I. Made Winarsa Ruma, I. Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka, Masakiyo Sakaguchi
Summary: LOXL4 is upregulated in breast cancer cells and interacts with annexin A2 and integrin beta-1 to promote breast cancer progression.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Jia-Yi Zhang, Wei-Wen Zhu, Meng-Yao Wang, Run-Dong Zhai, Qiong Wang, Wei-Li Shen, Lai-Kui Liu
Summary: Our study reveals that the high expression of LOX in CAFs can affect proliferation, migration, invasion, and EMT process of tumor cells, promoting the development of OSCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell Biology
Philip C. Trackman
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2018)
Article
Oncology
Ana de la Cueva, Michael Emmerling, Sarah L. Lim, Shi Yang, Philip C. Trackman, Gail E. Sonenshein, Kathrin H. Kirsch
Article
Dentistry, Oral Surgery & Medicine
D. Saxena, F. Mahjour, A. D. Findlay, E. A. Mously, A. Kantarci, P. C. Trackman
JOURNAL OF DENTAL RESEARCH
(2018)
Article
Dentistry, Oral Surgery & Medicine
C. R. Herzog, D. W. Berzins, P. DenBesten, R. L. Gregory, K. M. Hargreaves, R. L. W. Messer, M. Mina, M. P. Mooney, M. L. Paine, C. Phillips, R. B. Presland, R. G. Quivey, F. A. Scannapieco, J. F. Sheridan, K. K. H. Svoboda, P. C. Trackman, M. P. Walker, S. G. Walker, C. Y. Wang, J. C. C. Hu
JOURNAL OF DENTAL RESEARCH
(2018)
Meeting Abstract
Oncology
Faranak Mahjour, Philip C. Trackman
Article
Pathology
Dongjoon Kim, Dayeun Lee, Philip C. Trackman, Sayon Roy
AMERICAN JOURNAL OF PATHOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Philip C. Trackman, Yaser Peymanfar, Sayon Roy
Summary: Lysyl oxidases are multifunctional proteins involved in the biosynthesis and maturation of connective tissues. Their overexpression is associated with fibrosis and cancer, while their propeptide has tumor-suppressing effects. In diabetic retinopathy, lysyl oxidases are overexpressed and their propeptide levels are elevated. Further research is needed to understand the activities and mechanisms of lysyl oxidase propeptide.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yaser Peymanfar, Faranak Mahjour, Neha Shrestha, Ana de la Cueva, Ying Chen, Shengyuan Huang, Kathrin H. Kirsch, Xiaozhe Han, Philip C. Trackman
Summary: Oral cancer, primarily squamous-cell carcinoma with a 5-year survival rate of approximately 50%, is more common in humans carrying a polymorphism in the propeptide region of lysyl oxidase (LOX). Knockin mice carrying the same polymorphism are more susceptible to lesion development. The presence of wildtype LOX-PP in humans and mice has a tumor-inhibitory effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Philip C. C. Trackman
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Eileen J. Daley, Philip C. Trackman
Summary: This study reveals the mechanism by which GIP regulates LOX expression, mediated by beta-catenin. These findings provide important insights for designing potential therapeutic approaches to address deficient LOX production in diabetic bone disease by suggesting exploring strategies to stimulate beta-catenin signaling in osteoblasts under diabetic conditions as potential therapeutic strategies.
Meeting Abstract
Ophthalmology
Ngan Ha Nguyen, Dongjoon Kim, Philip C. Trackman, Sayon Roy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Endocrinology & Metabolism
Eileen J. Daley, Paola Divieti Pajevic, Sayon Roy, Philip C. Trackman
Article
Medicine, Research & Experimental
Vivian S. Lee, Carmen M. Halabi, Thomas J. Broekelmann, Philip C. Trackman, Nathan O. Stitziel, Robert P. Mecham
Meeting Abstract
Ophthalmology
Brian Chirn, Dongjoon Kim, Philip C. Trackman, Sayon Roy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)